| 1 | Wed Nov 10 | at #6Michigan | L76-88 | 0-1 | .000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 2 | Mon Nov 15 | at North Texas | W69-66 | 1-1 | .500 | - | | The Super Pit · Denton, TX |
| 3 | Sat Nov 20 | vs Rider | W87-65 | 2-1 | .667 | - | | Alumni Arena · Buffalo, NY |
| 4 | Tue Nov 23 | vs SF Austin | L78-79 | 2-2 | .500 | - | CBS | Alumni Arena · Buffalo, NY |
| 5 | Wed Nov 24 | at Illinois St | W106-90 | 3-2 | .600 | - | | Redbird Arena · Normal, IL |
| 6 | Mon Nov 29 | vs TBD | W94-49 | 4-2 | .667 | - | | Alumni Arena · Buffalo, NY |
| 7 | Sat Dec 4 | at St Bonaventure | L65-68 | 4-3 | .571 | - | | Reilly Center · Saint Bonaventure, NY |
| 8 | Wed Dec 8 | at Western KY | W77-67 | 5-3 | .625 | - | | E. A. Diddle Arena · Bowling Green, KY |
| 9 | Sat Dec 11 | vsTBD | W100-58 | 6-3 | .667 | - | | Alumni Arena · Buffalo, NY |
| 10 | Sat Dec 18 | at Canisius | L64-65 | 6-4 | .600 | - | | Koessler Athletic Center · Buffalo, NY |
| 12 | Wed Dec 29 | vs Miami OH | L81-91 | 6-5 | .545 | - | | Alumni Arena · Buffalo, NY |
| 13 | Sat Jan 1 | at E Michigan | PPD | 19-11 | .633 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 14 | Sat Jan 1 | at Akron | L76-88 | 6-6 | .500 | - | | James A. Rhodes Arena · Akron, OH |
| 15 | Tue Jan 4 | at N Illinois | PPD | 19-11 | .633 | - | | NIU Convocation Center · Dekalb, IL |
| 16 | Wed Jan 5 | vs Bowling Green | W99-88 | 7-6 | .538 | - | | Alumni Arena · Buffalo, NY |
| 17 | Tue Jan 11 | at W Michigan | W78-64 | 8-6 | .571 | - | | University Arena (MI) · Kalamazoo, MI |
| 18 | Fri Jan 14 | at Ball State | W74-68 | 9-6 | .600 | - | CBS | Worthen Arena · Muncie, IN |
| 20 | Fri Jan 21 | vs Kent State | W64-51 | 10-6 | .625 | - | CBS | Alumni Arena · Buffalo, NY |
| 21 | Tue Jan 25 | at Toledo | L75-86 | 10-7 | .588 | - | | Savage Arena · Toledo, OH |
| 22 | Fri Jan 28 | vs Ohio | L53-74 | 10-8 | .556 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 23 | Sat Feb 5 | at C Michigan | W74-54 | 11-8 | .579 | - | | McGuirk Arena · Mount Pleasant, MI |
| 24 | Tue Feb 8 | vsE Michigan | W102-64 | 12-8 | .600 | - | | Alumni Arena · Buffalo, NY |
| 25 | Sat Feb 12 | vsBall State | W80-74 | 13-8 | .619 | - | | Alumni Arena · Buffalo, NY |
| 26 | Tue Feb 15 | atBowling Green | W112-85 | 14-8 | .636 | - | | Stroh Center · Bowling Green, OH |
| 27 | Thu Feb 17 | atE Michigan | W83-69 | 15-8 | .652 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 28 | Sat Feb 19 | vsW Michigan | W87-73 | 16-8 | .667 | - | | Alumni Arena · Buffalo, NY |
| 29 | Tue Feb 22 | atMiami OH | W86-84 | 17-8 | .680 | - | | Millett Hall · Oxford, OH |
| 30 | Thu Feb 24 | atN Illinois | W79-68 | 18-8 | .692 | - | | NIU Convocation Center · Dekalb, IL |
| 31 | Sat Feb 26 | vsN Illinois | W70-60 | 19-8 | .704 | - | | Alumni Arena · Buffalo, NY |
| 32 | Tue Mar 1 | vsToledo | L76-92 | 19-9 | .679 | - | | Alumni Arena · Buffalo, NY |
| 33 | Fri Mar 4 | atKent State | L65-70 | 19-10 | .655 | - | ESPNU | M.A.C. Center · Kent, OH |
| 34 | Thu Mar 10 | atAkron | L68-70 | 19-11 | .633 | - | | James A. Rhodes Arena · Akron, OH |
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