| 1 | Mon Nov 3 | vs Southern Miss | 6:30 PM | 11-22 | .333 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 2 | Fri Nov 7 | vsGreen Bay | 6:30 PM | 4-28 | .125 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 3 | Tue Nov 11 | atDePaul | 8:00 PM | 14-20 | .412 | - | | Wintrust Arena · Chicago, IL |
| 4 | Sat Nov 15 | vsTBD | TBD | 0-0 | .000 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 5 | Tue Nov 18 | vsVermont | 6:30 PM | 21-12 | .636 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 6 | Mon Nov 24 | vsVMI | 2:30 PM | 15-19 | .441 | - | | Alumni Arena · Buffalo, NY |
| 7 | Wed Nov 26 | atBucknell | 1:30 PM | 18-15 | .545 | - | | Sojka Pavilion · Lewisburg, PA |
| 8 | Sat Nov 29 | atCanisius | 6:00 PM | 3-28 | .097 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 9 | Sat Dec 6 | vsSt Bonaventure | 2:00 PM | 22-12 | .647 | - | | Alumni Arena · Buffalo, NY |
| 10 | Tue Dec 9 | atUMBC | 5:00 PM | 13-19 | .406 | - | | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 11 | Sun Dec 14 | atE Carolina | 1:00 PM | 19-14 | .576 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Sat Dec 20 | atW Michigan | TBD | 12-20 | .375 | - | | University Arena (MI) · Kalamazoo, MI |
| 13 | Mon Dec 22 | vsTBD | 6:30 PM | 0-0 | .000 | - | | Alumni Arena · Buffalo, NY |
| 14 | Tue Dec 30 | atN Illinois | TBD | 6-25 | .194 | - | | NIU Convocation Center · Dekalb, IL |
| 15 | Sat Jan 3 | vsBall State | 2:00 PM | 14-17 | .452 | - | | Alumni Arena · Buffalo, NY |
| 16 | Sat Jan 10 | atOhio | TBD | 16-16 | .500 | - | | Convocation Center (OH) · Athens, OH |
| 17 | Tue Jan 13 | vsKent State | 6:30 PM | 24-12 | .667 | - | | Alumni Arena · Buffalo, NY |
| 18 | Sat Jan 17 | atMiami OH | 1:00 PM | 25-9 | .735 | - | | Millett Hall · Oxford, OH |
| 19 | Tue Jan 20 | vsAkron | 6:30 PM | 28-7 | .800 | - | | Alumni Arena · Buffalo, NY |
| 20 | Sat Jan 24 | vsUMass | TBD | 12-20 | .375 | - | | Alumni Arena · Buffalo, NY |
| 21 | Tue Jan 27 | atBowling Green | 7:00 PM | 14-18 | .438 | - | | Stroh Center · Bowling Green, OH |
| 22 | Sat Jan 31 | vsOhio | 2:00 PM | 16-16 | .500 | - | | Alumni Arena · Buffalo, NY |
| 23 | Tue Feb 3 | vsMiami OH | 6:30 PM | 25-9 | .735 | - | | Alumni Arena · Buffalo, NY |
| 24 | Wed Feb 11 | atBall State | 7:00 PM | 14-17 | .452 | - | | Worthen Arena · Muncie, IN |
| 25 | Tue Feb 17 | vsN Illinois | 6:30 PM | 6-25 | .194 | - | | Alumni Arena · Buffalo, NY |
| 26 | Sat Feb 21 | atUMass | 6:00 PM | 12-20 | .375 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Tue Feb 24 | atAkron | TBD | 28-7 | .800 | - | | James A. Rhodes Arena · Akron, OH |
| 28 | Sat Feb 28 | vsC Michigan | 2:00 PM | 14-17 | .452 | - | | Alumni Arena · Buffalo, NY |
| 29 | Tue Mar 3 | vsE Michigan | 6:30 PM | 16-16 | .500 | - | | Alumni Arena · Buffalo, NY |
| 30 | Fri Mar 6 | atToledo | TBD | 18-15 | .545 | - | | Savage Arena · Toledo, OH |
