| 1 | Mon Nov 3 | vs Southern Miss | W85-79 | 1-0 | 1.000 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 2 | Fri Nov 7 | vsGreen Bay | W83-76 | 2-0 | 1.000 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 3 | Tue Nov 11 | atDePaul | W66-53 | 3-0 | 1.000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 4 | Sat Nov 15 | vsTBD | W80-64 | 4-0 | 1.000 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 5 | Tue Nov 18 | vsVermont | W94-90 | 5-0 | 1.000 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 6 | Mon Nov 24 | vsVMI | W78-70 | 6-0 | 1.000 | - | | Alumni Arena · Buffalo, NY |
| 7 | Wed Nov 26 | atBucknell | W73-71 | 7-0 | 1.000 | - | | Sojka Pavilion · Lewisburg, PA |
| 8 | Sat Nov 29 | atCanisius | W71-53 | 8-0 | 1.000 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 9 | Sat Dec 6 | vsSt Bonaventure | L69-77 | 8-1 | .889 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 10 | Tue Dec 9 | atUMBC | W83-79 | 9-1 | .900 | - | ESPN+ | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 11 | Sun Dec 14 | atE Carolina | L70-73 | 9-2 | .818 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Sat Dec 20 | atW Michigan | W88-71 | 10-2 | .833 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 13 | Mon Dec 22 | vsTBD | W92-63 | 11-2 | .846 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 14 | Wed Dec 31 | atN Illinois | W81-67 | 12-2 | .857 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 15 | Sat Jan 3 | vsBall State | W85-72 | 13-2 | .867 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 16 | Sat Jan 10 | atOhio | L80-91 | 13-3 | .813 | - | ESPN+ | Convocation Center (OH) · Athens, OH |
| 17 | Tue Jan 13 | vsKent State | L81-87 | 13-4 | .765 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 18 | Sat Jan 17 | atMiami OH | L102-105 (OT) | 13-5 | .722 | - | ESPN+ | Millett Hall · Oxford, OH |
| 19 | Tue Jan 20 | vsAkron | L63-82 | 13-6 | .684 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 20 | Fri Jan 23 | vsUMass | L67-68 | 13-7 | .650 | - | CBSSN | Alumni Arena · Buffalo, NY |
| 21 | Tue Jan 27 | atBowling Green | W89-78 | 14-7 | .667 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 22 | Sat Jan 31 | vsOhio | L83-95 | 14-8 | .636 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 23 | Tue Feb 3 | vs23Miami OH | L71-73 | 14-9 | .609 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 24 | Sat Feb 7 | atSouth Alabama | L69-81 | 14-10 | .583 | - | ESPN+ | Mitchell Center · Mobile, AL |
| 25 | Wed Feb 11 | atBall State | W63-53 | 15-10 | .600 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 26 | Tue Feb 17 | vsN Illinois | L70-72 | 15-11 | .577 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 27 | Sat Feb 21 | atUMass | W86-82 (OT) | 16-11 | .593 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 28 | Tue Feb 24 | atAkron | L85-99 | 16-12 | .571 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 29 | Sat Feb 28 | vsC Michigan | L70-75 | 16-13 | .552 | - | ESPN+ | Alumni Arena · Buffalo, NY |
