| 1 | Wed Nov 25 | vs Illinois St | W94-67 | 1-0 | 1.000 | #23 | ESPN | Value City Arena · Columbus, OH |
| 2 | Sun Nov 29 | vsUMass Lowell | W74-64 | 2-0 | 1.000 | #23 | BTN | Value City Arena · Columbus, OH |
| 3 | Wed Dec 2 | vsMorehead St | W77-44 | 3-0 | 1.000 | #23 | BTN | Value City Arena · Columbus, OH |
| 5 | Tue Dec 8 | atNotre Dame | W90-85 | 4-0 | 1.000 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 6 | Sun Dec 13 | vsCleveland St | W67-61 | 5-0 | 1.000 | #22 | BTN | Value City Arena · Columbus, OH |
| 7 | Wed Dec 16 | atPurdue | L60-67 | 5-1 | .833 | #20 | BTN | Mackey Arena · West Lafayette, IN |
| 8 | Sat Dec 19 | vsUCLA | W77-70 | 6-1 | .857 | - | CBS | Value City Arena · Columbus, OH |
| 9 | Wed Dec 23 | vs11Rutgers | W80-68 | 7-1 | .875 | #23 | BTN | Value City Arena · Columbus, OH |
| 10 | Sat Dec 26 | atNorthwestern | L70-71 | 7-2 | .778 | #23 | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 11 | Wed Dec 30 | vsNebraska | W90-54 | 8-2 | .800 | #25 | BTN | Value City Arena · Columbus, OH |
| 12 | Sun Jan 3 | at21Minnesota | L60-77 | 8-3 | .727 | #25 | BTN | Williams Arena · Minneapolis, MN |
| 13 | Wed Jan 6 | vsPenn State | PPD | 21-10 | .677 | - | BTN | Value City Arena · Columbus, OH |
| 14 | Sat Jan 9 | at15Rutgers | W79-68 | 9-3 | .750 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 15 | Wed Jan 13 | vsNorthwestern | W81-71 | 10-3 | .769 | #21 | BTN | Value City Arena · Columbus, OH |
| 16 | Sat Jan 16 | at14Illinois | W87-81 | 11-3 | .786 | #21 | | State Farm Center · Champaign, IL |
| 17 | Tue Jan 19 | vsPurdue | L65-67 | 11-4 | .733 | #15 | BTN | Value City Arena · Columbus, OH |
| 18 | Sat Jan 23 | at10Wisconsin | W74-62 | 12-4 | .750 | #15 | CBS | Kohl Center · Madison, WI |
| 19 | Wed Jan 27 | vsPenn State | W83-79 | 13-4 | .765 | #13 | BTN | Value City Arena · Columbus, OH |
| 20 | Sun Jan 31 | vsMichigan St | W79-62 | 14-4 | .778 | #13 | CBS | Value City Arena · Columbus, OH |
| 21 | Thu Feb 4 | at8Iowa | W89-85 | 15-4 | .789 | #7 | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 22 | Mon Feb 8 | atMaryland | W73-65 | 16-4 | .800 | #4 | FS1 | XFINITY Center · College Park, MD |
| 23 | Sat Feb 13 | vsIndiana | W78-59 | 17-4 | .810 | #4 | ESPN | Value City Arena · Columbus, OH |
| 24 | Thu Feb 18 | atPenn State | W92-82 | 18-4 | .818 | #4 | BTN | Bryce Jordan Center · University Park, PA |
| 25 | Sun Feb 21 | vs3Michigan | L87-92 | 18-5 | .783 | #4 | CBS | Value City Arena · Columbus, OH |
| 26 | Thu Feb 25 | atMichigan St | L67-71 | 18-6 | .750 | #4 | ESPN | Breslin Center · East Lansing, MI |
| 27 | Sun Feb 28 | vs9Iowa | L57-73 | 18-7 | .720 | #4 | CBS | Value City Arena · Columbus, OH |
| 28 | Sat Mar 6 | vs4Illinois | L68-73 | 18-8 | .692 | #7 | ESPN | Value City Arena · Columbus, OH |
| 29 | Thu Mar 11 | vsMinnesota | W79-75 | 19-8 | .704 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
| 30 | Fri Mar 12 | atPurdue | W87-78 (OT) | 20-8 | .714 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
| 31 | Sat Mar 13 | atMichigan | W68-67 | 21-8 | .724 | - | CBS | Lucas Oil Stadium · Indianapolis, IN |
| 32 | Sun Mar 14 | atIllinois | L88-91 (OT) | 21-9 | .700 | - | CBS | Lucas Oil Stadium · Indianapolis, IN |
| 32 | Fri Mar 19 | vs15Oral Roberts | L72-75 (OT) | 21-10 | .677 | #2 | CBS | Mackey Arena · West Lafayette, IN |
