| 1 | Mon Nov 6 | vs Oakland | W79-73 | 1-0 | 1.000 | - | | Value City Arena · Columbus, OH |
| 2 | Fri Nov 10 | vs #15Texas A&M | L66-73 | 1-1 | .500 | - | | Value City Arena · Columbus, OH |
| 3 | Wed Nov 15 | vs Merrimack | W76-52 | 2-1 | .667 | - | BTN | Value City Arena · Columbus, OH |
| 4 | Sun Nov 19 | vs W Michigan | W73-56 | 3-1 | .750 | - | BTN | Value City Arena · Columbus, OH |
| 5 | Fri Nov 24 | vs #17Alabama | W92-81 | 4-1 | .800 | - | CBS | Value City Arena · Columbus, OH |
| 6 | Sat Nov 25 | at Santa Clara | W86-56 | 5-1 | .833 | - | | Leavey Center · Santa Clara, CA |
| 7 | Wed Nov 29 | vs C Michigan | W88-61 | 6-1 | .857 | - | BTN | Value City Arena · Columbus, OH |
| 8 | Sun Dec 3 | vs Minnesota | W84-74 | 7-1 | .875 | - | BTN | Value City Arena · Columbus, OH |
| 9 | Wed Dec 6 | vs Miami OH | W84-64 | 8-1 | .889 | - | | Value City Arena · Columbus, OH |
| 10 | Sat Dec 9 | at Penn State | L80-83 | 8-2 | .800 | - | BTN | Bryce Jordan Center · University Park, PA |
| 11 | Sat Dec 16 | vs UCLA | W67-60 | 9-2 | .818 | - | CBS | Value City Arena · Columbus, OH |
| 12 | Thu Dec 21 | vs New Orleans | W78-36 | 10-2 | .833 | - | | Value City Arena · Columbus, OH |
| 13 | Sat Dec 30 | vs West Virginia | W78-75 (OT) | 11-2 | .846 | - | FOX | Value City Arena · Columbus, OH |
| 14 | Wed Jan 3 | vs Rutgers | W76-72 | 12-2 | .857 | - | BTN | Value City Arena · Columbus, OH |
| 15 | Sat Jan 6 | at Indiana | L65-71 | 12-3 | .800 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 16 | Wed Jan 10 | vs #15Wisconsin | L60-71 | 12-4 | .750 | - | BTN | Value City Arena · Columbus, OH |
| 17 | Mon Jan 15 | at Michigan | L65-73 | 12-5 | .706 | - | FOX | Crisler Center · Ann Arbor, MI |
| 18 | Sat Jan 20 | vsPenn State | W79-67 | 13-5 | .722 | - | BTN | Value City Arena · Columbus, OH |
| 19 | Tue Jan 23 | at Nebraska | L69-83 | 13-6 | .684 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 20 | Sat Jan 27 | at Northwestern | L58-83 | 13-7 | .650 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 21 | Tue Jan 30 | vs #14Illinois | L75-87 | 13-8 | .619 | - | | Value City Arena · Columbus, OH |
| 22 | Fri Feb 2 | at Iowa | L77-79 | 13-9 | .591 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 23 | Tue Feb 6 | vsIndiana | L73-76 | 13-10 | .565 | - | | Value City Arena · Columbus, OH |
| 24 | Sat Feb 10 | vs Maryland | W79-75 (2OT) | 14-10 | .583 | - | FS1 | Value City Arena · Columbus, OH |
| 25 | Tue Feb 13 | at#20Wisconsin | L54-62 | 14-11 | .560 | - | | Kohl Center · Madison, WI |
| 26 | Sun Feb 18 | vs #2Purdue | W73-69 | 15-11 | .577 | - | CBS | Value City Arena · Columbus, OH |
| 27 | Thu Feb 22 | atMinnesota | L79-88 | 15-12 | .556 | - | BTN | Williams Arena · Minneapolis, MN |
| 28 | Sun Feb 25 | at Michigan St | W60-57 | 16-12 | .571 | - | CBS | Breslin Center · East Lansing, MI |
| 29 | Thu Feb 29 | vsNebraska | W78-69 | 17-12 | .586 | - | FS1 | Value City Arena · Columbus, OH |
| 30 | Sun Mar 3 | vsMichigan | W84-61 | 18-12 | .600 | - | CBS | Value City Arena · Columbus, OH |
| 31 | Sun Mar 10 | atRutgers | W73-51 | 19-12 | .613 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 32 | Thu Mar 14 | atIowa | W90-78 | 20-12 | .625 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 33 | Fri Mar 15 | at#13Illinois | L74-77 | 20-13 | .606 | - | BTN | State Farm Center · Champaign, IL |
| 34 | Tue Mar 19 | vs Cornell | W88-83 | 21-13 | .618 | - | ESPN2 | Value City Arena · Columbus, OH |
| 35 | Sat Mar 23 | vs Virginia Tech | W81-73 | 22-13 | .629 | - | | Value City Arena · Columbus, OH |
| 36 | Tue Mar 26 | vs Georgia | L77-79 | 22-14 | .611 | - | ESPN | Value City Arena · Columbus, OH |
