| 1 | Mon Nov 7 | vs Robert Morris | W91-53 | 1-0 | 1.000 | - | | Value City Arena · Columbus, OH |
| 2 | Thu Nov 10 | vs Charleston So | W82-56 | 2-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 3 | Wed Nov 16 | vs E Illinois | W65-43 | 3-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 4 | Mon Nov 21 | at SDSU | L77-88 | 3-1 | .750 | - | ESPN2 | Viejas Arena · San Diego, CA |
| 5 | Tue Nov 22 | at Cincinnati | W81-53 | 4-1 | .800 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 6 | Wed Nov 23 | vs Texas Tech | W80-73 | 5-1 | .833 | - | ESPN | Value City Arena · Columbus, OH |
| 7 | Wed Nov 30 | at Duke | L72-81 | 5-2 | .714 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 8 | Sat Dec 3 | vs St Francis PA | W96-59 | 6-2 | .750 | #25 | BTN | Value City Arena · Columbus, OH |
| 9 | Thu Dec 8 | vs Rutgers | W67-66 | 7-2 | .778 | #25 | ESPN2 | Value City Arena · Columbus, OH |
| 10 | Sat Dec 17 | at UNC | L84-89 (OT) | 7-3 | .700 | - | CBS | Dean E. Smith Center · Chapel Hill, NC |
| 11 | Wed Dec 21 | vs Maine | W95-61 | 8-3 | .727 | - | BTN | Value City Arena · Columbus, OH |
| 12 | Thu Dec 29 | vs Alabama A&M | W90-59 | 9-3 | .750 | - | BTN | Value City Arena · Columbus, OH |
| 13 | Sun Jan 1 | at Northwestern | W73-57 | 10-3 | .769 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 14 | Thu Jan 5 | vs #1Purdue | L69-71 | 10-4 | .714 | #24 | FS1 | Value City Arena · Columbus, OH |
| 15 | Sun Jan 8 | at Maryland | L73-80 | 10-5 | .667 | #24 | ESPN | XFINITY Center · College Park, MD |
| 16 | Thu Jan 12 | vs Minnesota | L67-70 | 10-6 | .625 | - | FS1 | Value City Arena · Columbus, OH |
| 17 | Sun Jan 15 | atRutgers | L64-68 (OT) | 10-7 | .588 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 18 | Wed Jan 18 | at Nebraska | L60-63 | 10-8 | .556 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 19 | Sat Jan 21 | vs Iowa | W93-77 | 11-8 | .579 | - | FOX | Value City Arena · Columbus, OH |
| 20 | Tue Jan 24 | at Illinois | L60-69 | 11-9 | .550 | - | ESPN | State Farm Center · Champaign, IL |
| 21 | Sat Jan 28 | at Indiana | L70-86 | 11-10 | .524 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Thu Feb 2 | vs Wisconsin | L60-65 | 11-11 | .500 | - | FS1 | Value City Arena · Columbus, OH |
| 23 | Sun Feb 5 | at Michigan | L69-77 | 11-12 | .478 | - | CBS | Crisler Center · Ann Arbor, MI |
| 24 | Thu Feb 9 | vsNorthwestern | L63-69 | 11-13 | .458 | - | FS1 | Value City Arena · Columbus, OH |
| 25 | Sun Feb 12 | vs Michigan St | L41-62 | 11-14 | .440 | - | CBS | Value City Arena · Columbus, OH |
| 26 | Thu Feb 16 | atIowa | L75-92 | 11-15 | .423 | - | ESPN2 | Carver-Hawkeye Arena · Iowa City, IA |
| 27 | Sun Feb 19 | at#3Purdue | L55-82 | 11-16 | .407 | - | CBS | Mackey Arena · West Lafayette, IN |
| 28 | Thu Feb 23 | vs Penn State | L71-75 | 11-17 | .393 | - | FS1 | Value City Arena · Columbus, OH |
| 29 | Sun Feb 26 | vsIllinois | W72-60 | 12-17 | .414 | - | CBS | Value City Arena · Columbus, OH |
| 30 | Wed Mar 1 | vs#21Maryland | W73-62 | 13-17 | .433 | - | BTN | Value City Arena · Columbus, OH |
| 31 | Sat Mar 4 | atMichigan St | L78-84 | 13-18 | .419 | - | ESPN | Breslin Center · East Lansing, MI |
| 32 | Wed Mar 8 | atWisconsin | W65-57 | 14-18 | .438 | - | BTN | Kohl Center · Madison, WI |
| 33 | Thu Mar 9 | atIowa | W73-69 | 15-18 | .455 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 34 | Fri Mar 10 | atMichigan St | W68-58 | 16-18 | .471 | - | BTN | Breslin Center · East Lansing, MI |
| 35 | Sat Mar 11 | atPurdue | L66-80 | 16-19 | .457 | - | CBS | Mackey Arena · West Lafayette, IN |
