| 1 | Tue Nov 9 | vs Akron | W67-66 | 1-0 | 1.000 | #17 | ESPN2 | Value City Arena · Columbus, OH |
| 2 | Fri Nov 12 | vs Niagara | W84-74 | 2-0 | 1.000 | #17 | | Value City Arena · Columbus, OH |
| 3 | Mon Nov 15 | vs Bowling Green | W89-58 | 3-0 | 1.000 | #19 | BTN | Value City Arena · Columbus, OH |
| 4 | Thu Nov 18 | at Xavier | L65-71 | 3-1 | .750 | - | FS1 | Cintas Center · Cincinnati, OH |
| 5 | Mon Nov 22 | vs Seton Hall | W79-76 | 4-1 | .800 | - | FS1 | Value City Arena · Columbus, OH |
| 6 | Wed Nov 24 | vs Florida | L68-71 | 4-2 | .667 | - | | Value City Arena · Columbus, OH |
| 7 | Tue Nov 30 | vs Duke | W71-66 | 5-2 | .714 | - | ESPN | Value City Arena · Columbus, OH |
| 8 | Sun Dec 5 | at Penn State | W76-64 | 6-2 | .750 | - | BTN | Bryce Jordan Center · University Park, PA |
| 9 | Wed Dec 8 | vs Towson | W85-74 | 7-2 | .778 | #21 | ESPNU | Value City Arena · Columbus, OH |
| 10 | Sat Dec 11 | vs #22Wisconsin | W73-55 | 8-2 | .800 | #21 | BTN | Value City Arena · Columbus, OH |
| 12 | Sun Jan 2 | at Nebraska | W87-79 (OT) | 9-2 | .818 | #13 | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 13 | Thu Jan 6 | at Indiana | L51-67 | 9-3 | .750 | #13 | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Sun Jan 9 | vs Northwestern | W95-87 | 10-3 | .769 | #13 | BTN | Value City Arena · Columbus, OH |
| 15 | Thu Jan 13 | at#13Wisconsin | L68-78 | 10-4 | .714 | #16 | ESPN2 | Kohl Center · Madison, WI |
| 16 | Sun Jan 16 | vsPenn State | W61-56 | 11-4 | .733 | #16 | BTN | Value City Arena · Columbus, OH |
| 17 | Tue Jan 18 | vs IU Indy | W83-37 | 12-4 | .750 | #19 | BTN | Value City Arena · Columbus, OH |
| 18 | Sat Jan 22 | vsNebraska | PPD | 20-12 | .625 | #19 | | Value City Arena · Columbus, OH |
| 19 | Thu Jan 27 | at Minnesota | W75-64 | 13-4 | .765 | #16 | ESPN | Williams Arena · Minneapolis, MN |
| 20 | Sun Jan 30 | at #6Purdue | L78-81 | 13-5 | .722 | #16 | CBS | Mackey Arena · West Lafayette, IN |
| 21 | Thu Feb 3 | vs Iowa | PPD | 20-12 | .625 | #16 | | Value City Arena · Columbus, OH |
| 22 | Sun Feb 6 | vs Maryland | W82-67 | 14-5 | .737 | #16 | CBS | Value City Arena · Columbus, OH |
| 23 | Wed Feb 9 | at Rutgers | L64-66 | 14-6 | .700 | #16 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 24 | Sat Feb 12 | at Michigan | W68-57 | 15-6 | .714 | #16 | ESPN | Crisler Center · Ann Arbor, MI |
| 25 | Tue Feb 15 | vsMinnesota | W70-45 | 16-6 | .727 | #18 | BTN | Value City Arena · Columbus, OH |
| 26 | Sat Feb 19 | vsIowa | L62-75 | 16-7 | .696 | #18 | | Value City Arena · Columbus, OH |
| 27 | Mon Feb 21 | vsIndiana | W80-69 (OT) | 17-7 | .708 | #22 | FS1 | Value City Arena · Columbus, OH |
| 28 | Thu Feb 24 | at #15Illinois | W86-83 | 18-7 | .720 | #22 | FS1 | State Farm Center · Champaign, IL |
| 29 | Sun Feb 27 | atMaryland | L60-75 | 18-8 | .692 | #22 | CBS | XFINITY Center · College Park, MD |
| 30 | Tue Mar 1 | vsNebraska | L70-78 | 18-9 | .667 | #23 | BTN | Value City Arena · Columbus, OH |
| 31 | Thu Mar 3 | vs Michigan St | W80-69 | 19-9 | .679 | #23 | ESPN | Value City Arena · Columbus, OH |
| 32 | Sun Mar 6 | vsMichigan | L69-75 | 19-10 | .655 | #23 | FOX | Value City Arena · Columbus, OH |
| 33 | Thu Mar 10 | vsPenn State | L68-71 | 19-11 | .633 | - | BTN | Value City Arena · Columbus, OH |
| 34 | Fri Mar 18 | vs #10Loyola Chicago | W54-41 | 20-11 | .645 | #7 | CBS | Value City Arena · Columbus, OH |
| 35 | Sun Mar 20 | at #2Villanova | L61-71 | 20-12 | .625 | #7 | CBS | Finneran Pavilion · Villanova, PA |
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