| 1 | Wed Nov 6 | vs Cincinnati | W64-56 | 1-0 | 1.000 | #18 | FS1 | Value City Arena · Columbus, OH |
| 2 | Sun Nov 10 | vs UMass Lowell | W76-56 | 2-0 | 1.000 | #18 | ESPNU | Value City Arena · Columbus, OH |
| 3 | Wed Nov 13 | vs Villanova | W76-51 | 3-0 | 1.000 | - | FS1 | Value City Arena · Columbus, OH |
| 4 | Mon Nov 18 | vs Stetson | W86-51 | 4-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 5 | Fri Nov 22 | vs Purdue FW | W85-46 | 5-0 | 1.000 | #10 | | Value City Arena · Columbus, OH |
| 6 | Mon Nov 25 | vs Kent State | W71-52 | 6-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 7 | Fri Nov 29 | vs Morgan St | W90-57 | 7-0 | 1.000 | #10 | BTN | Value City Arena · Columbus, OH |
| 8 | Wed Dec 4 | at UNC | W74-49 | 8-0 | 1.000 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 9 | Sat Dec 7 | vs Penn State | W106-74 | 9-0 | 1.000 | #6 | BTN | Value City Arena · Columbus, OH |
| 10 | Sun Dec 15 | at Minnesota | L71-84 | 9-1 | .900 | #3 | BTN | Williams Arena · Minneapolis, MN |
| 11 | Tue Dec 17 | vs SE Missouri St | W80-48 | 10-1 | .909 | #5 | BTN | Value City Arena · Columbus, OH |
| 12 | Sat Dec 21 | at Kentucky | W71-65 | 11-1 | .917 | - | CBS | Rupp Arena · Lexington, KY |
| 13 | Sun Dec 29 | vs #22West Virginia | L59-67 | 11-2 | .846 | #2 | FS1 | Value City Arena · Columbus, OH |
| 14 | Fri Jan 3 | vs Wisconsin | L57-61 | 11-3 | .786 | #5 | FS1 | Value City Arena · Columbus, OH |
| 15 | Tue Jan 7 | at #12Maryland | L55-67 | 11-4 | .733 | #11 | ESPN | XFINITY Center · College Park, MD |
| 16 | Sat Jan 11 | at Indiana | L54-66 | 11-5 | .688 | #11 | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 17 | Tue Jan 14 | vs Nebraska | W80-68 | 12-5 | .706 | #21 | FS1 | Value City Arena · Columbus, OH |
| 18 | Sat Jan 18 | atPenn State | L76-90 | 12-6 | .667 | #21 | ESPNU | Bryce Jordan Center · University Park, PA |
| 19 | Thu Jan 23 | vsMinnesota | L59-62 | 12-7 | .632 | - | FS1 | Value City Arena · Columbus, OH |
| 20 | Sun Jan 26 | at Northwestern | W71-59 | 13-7 | .650 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 21 | Sat Feb 1 | vsIndiana | W68-59 | 14-7 | .667 | - | ESPN | Value City Arena · Columbus, OH |
| 22 | Tue Feb 4 | at Michigan | W61-58 | 15-7 | .682 | - | ESPN2 | Crisler Center · Ann Arbor, MI |
| 23 | Sun Feb 9 | atWisconsin | L57-70 | 15-8 | .652 | - | CBS | Kohl Center · Madison, WI |
| 24 | Wed Feb 12 | vs Rutgers | W72-66 | 16-8 | .667 | - | BTN | Value City Arena · Columbus, OH |
| 25 | Sat Feb 15 | vs Purdue | W68-52 | 17-8 | .680 | - | FOX | Value City Arena · Columbus, OH |
| 26 | Thu Feb 20 | at #20Iowa | L76-85 | 17-9 | .654 | #25 | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 27 | Sun Feb 23 | vs#7Maryland | W79-72 | 18-9 | .667 | #25 | CBS | Value City Arena · Columbus, OH |
| 28 | Thu Feb 27 | atNebraska | W75-54 | 19-9 | .679 | #23 | ESPN2 | Pinnacle Bank Arena · Lincoln, NE |
| 29 | Sun Mar 1 | vs#19Michigan | W77-63 | 20-9 | .690 | #23 | CBS | Value City Arena · Columbus, OH |
| 30 | Thu Mar 5 | vs #23Illinois | W71-63 | 21-9 | .700 | #19 | ESPN | Value City Arena · Columbus, OH |
| 31 | Sun Mar 8 | at #16Michigan St | L69-80 | 21-10 | .677 | #19 | CBS | Breslin Center · East Lansing, MI |
