| 1 | Mon Nov 6 | vs Missouri St | W67-59 | 1-0 | 1.000 | - | | WVU Coliseum · Morgantown, WV |
| 2 | Fri Nov 10 | vsMonmouth | L65-73 | 1-1 | .500 | - | | WVU Coliseum · Morgantown, WV |
| 3 | Tue Nov 14 | vsJ'Ville St | W70-57 | 2-1 | .667 | - | | WVU Coliseum · Morgantown, WV |
| 4 | Mon Nov 20 | vsSMU | L58-70 | 2-2 | .500 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 5 | Wed Nov 22 | at#24Virginia | L54-56 | 2-3 | .400 | - | FS1 | John Paul Jones Arena · Charlottesville, VA |
| 6 | Sun Nov 26 | vsBellarmine | W62-58 | 3-3 | .500 | - | | WVU Coliseum · Morgantown, WV |
| 7 | Fri Dec 1 | vsSt John's | L73-79 | 3-4 | .429 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 8 | Wed Dec 6 | vsPitt | L63-80 | 3-5 | .375 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 9 | Sat Dec 9 | vsDrexel | W66-60 | 4-5 | .444 | - | | WVU Coliseum · Morgantown, WV |
| 10 | Sat Dec 16 | atUMass | L79-87 | 4-6 | .400 | - | ESPNU | William D. Mullins Memorial Center · Amherst, MA |
| 11 | Wed Dec 20 | vsRadford | L65-66 | 4-7 | .364 | - | | WVU Coliseum · Morgantown, WV |
| 12 | Sat Dec 23 | vsToledo | W91-81 | 5-7 | .417 | - | | WVU Coliseum · Morgantown, WV |
| 13 | Sat Dec 30 | atOhio State | L75-78 (OT) | 5-8 | .385 | - | FOX | Value City Arena · Columbus, OH |
| 14 | Sat Jan 6 | at#3Houston | L55-89 | 5-9 | .357 | - | | Fertitta Center · Houston, TX |
| 15 | Tue Jan 9 | vsKansas St | L67-81 | 5-10 | .333 | - | | WVU Coliseum · Morgantown, WV |
| 16 | Sat Jan 13 | vs#25Texas | W76-73 | 6-10 | .375 | - | | WVU Coliseum · Morgantown, WV |
| 17 | Wed Jan 17 | at#15Oklahoma | L63-77 | 6-11 | .353 | - | | Lloyd Noble Center · Norman, OK |
| 18 | Sat Jan 20 | vs#3Kansas | W91-85 | 7-11 | .389 | - | | WVU Coliseum · Morgantown, WV |
| 19 | Tue Jan 23 | atUCF | L59-72 | 7-12 | .368 | - | | Addition Financial Arena · Orlando, FL |
| 20 | Sat Jan 27 | atOklahoma St | L66-70 | 7-13 | .350 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 21 | Wed Jan 31 | vsCincinnati | W69-65 | 8-13 | .381 | - | | WVU Coliseum · Morgantown, WV |
| 22 | Sat Feb 3 | vs#22BYU | L73-86 | 8-14 | .364 | - | | WVU Coliseum · Morgantown, WV |
| 23 | Sat Feb 10 | atTexas | L58-94 | 8-15 | .348 | - | LHN | Moody Center · Austin, TX |
| 24 | Mon Feb 12 | atTCU | L65-81 | 8-16 | .333 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 25 | Sat Feb 17 | vs#12Baylor | L81-94 | 8-17 | .320 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 26 | Tue Feb 20 | vsUCF | W77-67 | 9-17 | .346 | - | ESPNU | WVU Coliseum · Morgantown, WV |
| 27 | Sat Feb 24 | at#6Iowa State | L64-71 | 9-18 | .333 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 28 | Mon Feb 26 | atKansas St | L90-94 (OT) | 9-19 | .321 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 29 | Sat Mar 2 | vsTexas Tech | L70-81 | 9-20 | .310 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 30 | Wed Mar 6 | vsTCU | L81-93 | 9-21 | .300 | - | | WVU Coliseum · Morgantown, WV |
| 31 | Sat Mar 9 | atCincinnati | L56-92 | 9-22 | .290 | - | | Fifth Third Arena · Cincinnati, OH |
| 32 | Tue Mar 12 | atCincinnati | L85-90 | 9-23 | .281 | - | | Fifth Third Arena · Cincinnati, OH |
