| 1 | Mon Nov 7 | vs Wagner | L73-76 (OT) | 0-1 | .000 | - | | Liacouras Center · Philadelphia, PA |
| 2 | Fri Nov 11 | vs #16Villanova | W68-64 | 1-1 | .500 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 3 | Tue Nov 15 | vs Vanderbilt | L87-89 (OT) | 1-2 | .333 | - | | Liacouras Center · Philadelphia, PA |
| 4 | Fri Nov 18 | at Rutgers | W72-66 | 2-2 | .500 | - | ESPNU | Jersey Mike’s Arena · Piscataway, NJ |
| 5 | Mon Nov 21 | vs St John's | L72-78 | 2-3 | .400 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 6 | Tue Nov 22 | at Richmond | L49-61 | 2-4 | .333 | - | ESPN2 | Robins Center · Richmond, VA |
| 7 | Sun Nov 27 | vs Drexel | W73-61 | 3-4 | .429 | - | | Liacouras Center · Philadelphia, PA |
| 8 | Wed Nov 30 | at La Salle | W67-51 | 4-4 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 9 | Sat Dec 3 | vs VCU | W83-73 | 5-4 | .556 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 10 | Tue Dec 6 | vs Saint Joseph's | W70-60 | 6-4 | .600 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 11 | Sat Dec 10 | at Penn | L57-77 | 6-5 | .545 | - | | The Palestra · Philadelphia, PA |
| 12 | Sat Dec 17 | at Ole Miss | L55-63 | 6-6 | .500 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 13 | Tue Dec 20 | vs MD-Eastern | L78-86 | 6-7 | .462 | - | | Liacouras Center · Philadelphia, PA |
| 14 | Wed Dec 28 | at E Carolina | W59-57 | 7-7 | .500 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 15 | Sun Jan 1 | vs Cincinnati | W70-61 | 8-7 | .533 | - | ESPN | Liacouras Center · Philadelphia, PA |
| 16 | Wed Jan 4 | at South Florida | W68-64 | 9-7 | .563 | - | | Yuengling Center · Tampa, FL |
| 17 | Sat Jan 7 | vs Tulane | L76-87 | 9-8 | .529 | - | | Liacouras Center · Philadelphia, PA |
| 18 | Tue Jan 10 | at Tulsa | W76-72 | 10-8 | .556 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 19 | Sun Jan 15 | vs Memphis | L59-61 | 10-9 | .526 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 20 | Wed Jan 18 | vsE Carolina | W73-58 | 11-9 | .550 | - | | Liacouras Center · Philadelphia, PA |
| 21 | Sun Jan 22 | at #1Houston | W56-55 | 12-9 | .571 | - | ESPN | Fertitta Center · Houston, TX |
| 22 | Wed Jan 25 | vsSouth Florida | W79-76 (OT) | 13-9 | .591 | - | | Liacouras Center · Philadelphia, PA |
| 23 | Sat Jan 28 | at UCF | W77-70 (OT) | 14-9 | .609 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 24 | Sun Feb 5 | vs#3Houston | L65-81 | 14-10 | .583 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 25 | Wed Feb 8 | at SMU | L71-72 | 14-11 | .560 | - | | Moody Coliseum · Dallas, TX |
| 26 | Sun Feb 12 | atMemphis | L77-86 | 14-12 | .538 | - | ESPN2 | FedExForum · Memphis, TN |
| 27 | Thu Feb 16 | vs Wichita St | L65-79 | 14-13 | .519 | - | | Liacouras Center · Philadelphia, PA |
| 28 | Sun Feb 19 | vsTulsa | W76-53 | 15-13 | .536 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 29 | Wed Feb 22 | atCincinnati | L83-88 (OT) | 15-14 | .517 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 30 | Thu Mar 2 | vsUCF | W57-55 | 16-14 | .533 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 31 | Sun Mar 5 | atTulane | L82-83 | 16-15 | .516 | - | | Devlin Fieldhouse · New Orleans, LA |
| 32 | Fri Mar 10 | atCincinnati | L54-84 | 16-16 | .500 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
