| 1 | Mon Nov 6 | vs MD-Eastern | W85-65 | 1-0 | 1.000 | - | | Liacouras Center · Philadelphia, PA |
| 2 | Fri Nov 10 | at Navy | W75-68 | 2-0 | 1.000 | - | CBS | Alumni Hall (Navy) · Annapolis, MD |
| 3 | Tue Nov 14 | at Drexel | W66-64 | 3-0 | 1.000 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 4 | Sat Nov 18 | vs Columbia | L73-78 | 3-1 | .750 | - | | Liacouras Center · Philadelphia, PA |
| 5 | Wed Nov 22 | vs Ole Miss | L76-77 | 3-2 | .600 | - | | Liacouras Center · Philadelphia, PA |
| 6 | Wed Nov 29 | vs La Salle | W106-99 (3OT) | 4-2 | .667 | - | | Liacouras Center · Philadelphia, PA |
| 7 | Sat Dec 2 | at Saint Joseph's | L65-74 | 4-3 | .571 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 8 | Wed Dec 6 | vs TBD | W85-55 | 5-3 | .625 | - | | Liacouras Center · Philadelphia, PA |
| 9 | Sun Dec 10 | at Albany | W78-73 | 6-3 | .667 | - | | SEFCU Arena · Albany, NY |
| 10 | Sat Dec 16 | at VCU | L78-87 | 6-4 | .600 | - | | Stuart C. Siegel Center · Richmond, VA |
| 11 | Thu Dec 21 | vs Nevada | L56-80 | 6-5 | .545 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 12 | Fri Dec 22 | at Old Dominion | L63-78 | 6-6 | .500 | - | | Chartway Arena · Norfolk, VA |
| 13 | Sun Dec 24 | at Portland | W55-54 | 7-6 | .538 | - | ESPN2 | Chiles Center · Portland, OR |
| 14 | Thu Jan 4 | at South Florida | L68-76 | 7-7 | .500 | - | | Yuengling Center · Tampa, FL |
| 15 | Sun Jan 7 | vs Wichita St | W68-61 | 8-7 | .533 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 16 | Wed Jan 10 | vs E Carolina | L62-73 | 8-8 | .500 | - | | Liacouras Center · Philadelphia, PA |
| 17 | Sat Jan 13 | at North Texas | L51-69 | 8-9 | .471 | - | ESPN2 | The Super Pit · Denton, TX |
| 18 | Tue Jan 16 | at SMU | L64-77 | 8-10 | .444 | - | | Moody Coliseum · Dallas, TX |
| 19 | Sat Jan 20 | vs Rice | L66-69 | 8-11 | .421 | - | | Liacouras Center · Philadelphia, PA |
| 20 | Wed Jan 24 | vsSouth Florida | L69-75 | 8-12 | .400 | - | | Liacouras Center · Philadelphia, PA |
| 21 | Sun Jan 28 | atE Carolina | L64-70 (OT) | 8-13 | .381 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sun Feb 4 | at Tulane | L80-92 (OT) | 8-14 | .364 | - | ESPNU | Devlin Fieldhouse · New Orleans, LA |
| 23 | Thu Feb 8 | vs Memphis | L77-84 | 8-15 | .348 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 24 | Sun Feb 11 | vs Charlotte | L70-73 | 8-16 | .333 | - | | Liacouras Center · Philadelphia, PA |
| 25 | Thu Feb 15 | at #24FAU | L68-80 | 8-17 | .320 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 26 | Sun Feb 18 | vs UTSA | W83-77 | 9-17 | .346 | - | | Liacouras Center · Philadelphia, PA |
| 27 | Sun Feb 25 | atWichita St | W72-66 (OT) | 10-17 | .370 | - | ESPN | Charles Koch Arena · Wichita, KS |
| 28 | Wed Feb 28 | atRice | W65-43 | 11-17 | .393 | - | | Tudor Fieldhouse · Houston, TX |
| 29 | Sat Mar 2 | vs Tulsa | L67-72 | 11-18 | .379 | - | | Liacouras Center · Philadelphia, PA |
| 30 | Thu Mar 7 | vs UAB | L72-100 | 11-19 | .367 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 31 | Sun Mar 10 | atUTSA | W84-82 | 12-19 | .387 | - | | UTSA Convocation Center · San Antonio, TX |
| 32 | Wed Mar 13 | vsUTSA | W64-61 | 13-19 | .406 | - | | Liacouras Center · Philadelphia, PA |
| 33 | Thu Mar 14 | atSMU | W75-60 | 14-19 | .424 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 34 | Fri Mar 15 | atCharlotte | W58-54 | 15-19 | .441 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 35 | Sat Mar 16 | atFAU | W74-73 | 16-19 | .457 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 36 | Sun Mar 17 | atUAB | L69-85 | 16-20 | .444 | - | ESPN | Bartow Arena · Birmingham, AL |
