| 1 | Wed Nov 6 | vs SE Missouri St | W83-65 | 1-0 | 1.000 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 2 | Mon Nov 11 | vs Texas A&M-CC | W71-66 | 2-0 | 1.000 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 3 | Thu Nov 14 | at Richmond | L92-93 (OT) | 2-1 | .667 | - | | Robins Center · Richmond, VA |
| 4 | Wed Nov 20 | vs Austin Peay | W90-72 | 3-1 | .750 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Fri Nov 22 | vs SC State | W97-60 | 4-1 | .800 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 6 | Mon Nov 25 | vs SE Louisiana | W78-70 | 5-1 | .833 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 7 | Sat Nov 30 | vs Tulsa | L58-67 | 5-2 | .714 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 8 | Tue Dec 3 | vs Buffalo | W90-76 | 6-2 | .750 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 9 | Sat Dec 14 | vs Liberty | L56-61 | 6-3 | .667 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 10 | Wed Dec 18 | vs Loyola Chicago | L70-78 | 6-4 | .600 | - | CBS | Memorial Gymnasium (TN) · Nashville, TN |
| 11 | Sat Dec 21 | vs UNC Wilmington | W88-73 | 7-4 | .636 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 12 | Mon Dec 30 | vs Davidson | W76-71 | 8-4 | .667 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 13 | Sat Jan 4 | vs SMU | L81-92 (OT) | 8-5 | .615 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 14 | Wed Jan 8 | at #5Auburn | L79-83 | 8-6 | .571 | - | SEC Network | Neville Arena · Auburn, AL |
| 15 | Sat Jan 11 | vs Texas A&M | L50-69 | 8-7 | .533 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Wed Jan 15 | at Arkansas | L55-75 | 8-8 | .500 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 17 | Sat Jan 18 | vs Tennessee | L45-66 | 8-9 | .471 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 18 | Wed Jan 22 | vs Alabama | L62-77 | 8-10 | .444 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 19 | Sat Jan 25 | at South Carolina | L64-90 | 8-11 | .421 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Wed Jan 29 | at #13Kentucky | L62-71 | 8-12 | .400 | - | SEC Network | Rupp Arena · Lexington, KY |
| 21 | Sat Feb 1 | vs Florida | L55-61 | 8-13 | .381 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Wed Feb 5 | vs #18LSU | W99-90 | 9-13 | .409 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 23 | Sat Feb 8 | at Mississippi St | L70-80 | 9-14 | .391 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 24 | Tue Feb 11 | vs#12Kentucky | L64-78 | 9-15 | .375 | - | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 15 | atFlorida | L66-84 | 9-16 | .360 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 26 | Tue Feb 18 | atTennessee | L61-65 | 9-17 | .346 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 27 | Sat Feb 22 | vs Georgia | L78-80 | 9-18 | .333 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 28 | Wed Feb 26 | vs Missouri | L52-61 | 9-19 | .321 | - | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
| 29 | Sat Feb 29 | at Ole Miss | L60-86 | 9-20 | .310 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 30 | Tue Mar 3 | atAlabama | W87-79 | 10-20 | .333 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 31 | Sat Mar 7 | vsSouth Carolina | W83-74 | 11-20 | .355 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 32 | Wed Mar 11 | atArkansas | L73-86 | 11-21 | .344 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
