| 1 | Mon Nov 3 | vs Lipscomb | W105-61 | 1-0 | 1.000 | - | SECN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 2 | Sat Nov 8 | atUCF | W105-93 | 2-0 | 1.000 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 3 | Wed Nov 12 | vsE Kentucky | W92-62 | 3-0 | 1.000 | - | SECN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 4 | Sat Nov 15 | vsAR-Pine Bluff | W104-75 | 4-0 | 1.000 | - | SECN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Thu Nov 20 | vsTexas So | W109-74 | 5-0 | 1.000 | - | SECN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 6 | Wed Nov 26 | atWestern KY | W83-78 | 6-0 | 1.000 | #24 | ESPN | E. A. Diddle Arena · Bowling Green, KY |
| 7 | Thu Nov 27 | vsVCU | W89-74 | 7-0 | 1.000 | #24 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 8 | Fri Nov 28 | vsSaint Mary's | W96-71 | 8-0 | 1.000 | #24 | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 9 | Wed Dec 3 | vsSMU | W88-69 | 9-0 | 1.000 | #17 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 10 | Sat Dec 13 | vsC Arkansas | W83-72 | 10-0 | 1.000 | #15 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 11 | Wed Dec 17 | atMemphis | W77-70 (OT) | 11-0 | 1.000 | #13 | ESPN2 | FedExForum · Memphis, TN |
| 12 | Sun Dec 21 | atWake Forest | W98-67 | 12-0 | 1.000 | #13 | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 13 | Mon Dec 29 | vsNew Haven | W96-53 | 13-0 | 1.000 | #11 | SECN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 14 | Sat Jan 3 | atSouth Carolina | W83-71 | 14-0 | 1.000 | #11 | ESPNU | Colonial Life Arena · Columbia, SC |
| 15 | Wed Jan 7 | vs13Alabama | W96-90 | 15-0 | 1.000 | #11 | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Sat Jan 10 | vsLSU | W84-73 | 16-0 | 1.000 | #11 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 17 | Wed Jan 14 | atTexas | L64-80 | 16-1 | .941 | #10 | ESPN2 | Moody Center · Austin, TX |
| 18 | Sat Jan 17 | vs19Florida | L94-98 | 16-2 | .889 | #10 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 19 | Tue Jan 20 | at20Arkansas | L68-93 | 16-3 | .842 | #15 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 20 | Sat Jan 24 | atMississippi St | W88-56 | 17-3 | .850 | #15 | SECN+ | Humphrey Coliseum · Starkville, MS |
| 21 | Tue Jan 27 | vsKentucky | W80-55 | 18-3 | .857 | #18 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Sat Jan 31 | vsOle Miss | W71-68 | 19-3 | .864 | #18 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 23 | Sat Feb 7 | vsOklahoma | L91-92 | 19-4 | .826 | #15 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 24 | Tue Feb 10 | atAuburn | W84-76 | 20-4 | .833 | #19 | SEC Network | Neville Arena · Auburn, AL |
| 25 | Sat Feb 14 | vsTexas A&M | W82-69 | 21-4 | .840 | #19 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 26 | Wed Feb 18 | atMissouri | L80-81 | 21-5 | .808 | #19 | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 21 | vsTennessee | L65-69 | 21-6 | .778 | #19 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 28 | Wed Feb 25 | vsGeorgia | W88-80 | 22-6 | .786 | #25 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 29 | Sat Feb 28 | atKentucky | L77-91 | 22-7 | .759 | #25 | ESPN | Rupp Arena · Lexington, KY |
