| 1 | Mon Nov 6 | vs Tennessee Tech | W80-42 | 1-0 | 1.000 | #9 | | Thompson-Boling Arena · Knoxville, TN |
| 2 | Fri Nov 10 | at Wisconsin | W80-70 | 2-0 | 1.000 | #9 | | Kohl Center · Madison, WI |
| 3 | Tue Nov 14 | vs Wofford | W82-61 | 3-0 | 1.000 | #7 | | Thompson-Boling Arena · Knoxville, TN |
| 4 | Mon Nov 20 | at Syracuse | W73-56 | 4-0 | 1.000 | #7 | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 5 | Tue Nov 21 | at #2Purdue | L67-71 | 4-1 | .800 | #7 | ESPN | Mackey Arena · West Lafayette, IN |
| 6 | Wed Nov 22 | at #1Kansas | L60-69 | 4-2 | .667 | #7 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 7 | Wed Nov 29 | at #17UNC | L92-100 | 4-3 | .571 | #10 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 8 | Tue Dec 5 | vs George Mason | W87-66 | 5-3 | .625 | #17 | | Thompson-Boling Arena · Knoxville, TN |
| 9 | Sat Dec 9 | vs #20Illinois | W86-79 | 6-3 | .667 | #17 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 10 | Tue Dec 12 | vs Georgia So | W74-56 | 7-3 | .700 | #12 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 11 | Sat Dec 16 | vs NC State | W79-70 | 8-3 | .727 | #12 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 12 | Thu Dec 21 | vs Tarleton | W65-46 | 9-3 | .750 | #8 | | Thompson-Boling Arena · Knoxville, TN |
| 13 | Tue Jan 2 | vs Norfolk St | W87-50 | 10-3 | .769 | #5 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 14 | Sat Jan 6 | vs #22Ole Miss | W90-64 | 11-3 | .786 | #5 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 15 | Wed Jan 10 | at Mississippi St | L72-77 | 11-4 | .733 | #5 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 16 | Sat Jan 13 | at Georgia | W85-79 | 12-4 | .750 | #5 | ESPN2 | Stegeman Coliseum · Athens, GA |
| 17 | Tue Jan 16 | vs Florida | W85-66 | 13-4 | .765 | #6 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 18 | Sat Jan 20 | vs Alabama | W91-71 | 14-4 | .778 | #6 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 19 | Sat Jan 27 | at Vanderbilt | W75-62 | 15-4 | .789 | #5 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 20 | Tue Jan 30 | vs South Carolina | L59-63 | 15-5 | .750 | #5 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 21 | Sat Feb 3 | at #10Kentucky | W103-92 | 16-5 | .762 | #5 | ESPN | Rupp Arena · Lexington, KY |
| 22 | Wed Feb 7 | vs LSU | W88-68 | 17-5 | .773 | #6 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 23 | Sat Feb 10 | at Texas A&M | L69-85 | 17-6 | .739 | #6 | ESPN | Reed Arena · College Station, TX |
| 24 | Wed Feb 14 | at Arkansas | W92-63 | 18-6 | .750 | #8 | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 25 | Sat Feb 17 | vsVanderbilt | W88-53 | 19-6 | .760 | #8 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 26 | Tue Feb 20 | at Missouri | W72-67 | 20-6 | .769 | #5 | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 24 | vsTexas A&M | W86-51 | 21-6 | .778 | #5 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 28 | Wed Feb 28 | vs #11Auburn | W92-84 | 22-6 | .786 | #4 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 29 | Sat Mar 2 | at#14Alabama | W81-74 | 23-6 | .793 | #4 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 30 | Wed Mar 6 | at#17South Carolina | W66-59 | 24-6 | .800 | #4 | ESPN2 | Colonial Life Arena · Columbia, SC |
| 31 | Sat Mar 9 | vs#15Kentucky | L81-85 | 24-7 | .774 | #4 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 32 | Fri Mar 15 | vsMississippi St | L56-73 | 24-8 | .750 | #5 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 33 | Thu Mar 21 | vs #15Saint Peter's | W83-49 | 25-8 | .758 | #2 | TNT | Thompson-Boling Arena · Knoxville, TN |
| 34 | Sat Mar 23 | vs #7Texas | W62-58 | 26-8 | .765 | #2 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 35 | Fri Mar 29 | vs #3Creighton | W82-75 | 27-8 | .771 | #2 | TBS | Thompson-Boling Arena · Knoxville, TN |
| 36 | Sun Mar 31 | at#1Purdue | L66-72 | 27-9 | .750 | #2 | CBS | Mackey Arena · West Lafayette, IN |
