| 1 | Tue Nov 5 | vs UNC Asheville | W78-63 | 1-0 | 1.000 | - | | Thompson-Boling Arena · Knoxville, TN |
| 2 | Tue Nov 12 | vsMurray St | W82-63 | 2-0 | 1.000 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 3 | Sat Nov 16 | vsWashington | W75-62 | 3-0 | 1.000 | - | | Thompson-Boling Arena · Knoxville, TN |
| 4 | Wed Nov 20 | vsAlabama St | W76-41 | 4-0 | 1.000 | - | | Thompson-Boling Arena · Knoxville, TN |
| 5 | Mon Nov 25 | vsChattanooga | W58-46 | 5-0 | 1.000 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 6 | Fri Nov 29 | vsFlorida St | L57-60 | 5-1 | .833 | - | CBSSN | Thompson-Boling Arena · Knoxville, TN |
| 7 | Sat Nov 30 | atVCU | W72-69 | 6-1 | .857 | - | | Stuart C. Siegel Center · Richmond, VA |
| 8 | Wed Dec 4 | vsFAMU | W72-43 | 7-1 | .875 | #21 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 9 | Sat Dec 14 | vs13Memphis | L47-51 | 7-2 | .778 | #19 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 10 | Wed Dec 18 | atCincinnati | L66-78 | 7-3 | .700 | #21 | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 11 | Sat Dec 21 | vsJ'Ville St | W75-53 | 8-3 | .727 | #21 | | Thompson-Boling Arena · Knoxville, TN |
| 12 | Sat Dec 28 | vsWisconsin | L48-68 | 8-4 | .667 | - | CBS | Thompson-Boling Arena · Knoxville, TN |
| 13 | Sat Jan 4 | vsLSU | L64-78 | 8-5 | .615 | - | ESPNU | Thompson-Boling Arena · Knoxville, TN |
| 14 | Tue Jan 7 | atMissouri | W69-59 | 9-5 | .643 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 15 | Sat Jan 11 | vsSouth Carolina | W56-55 | 10-5 | .667 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 16 | Wed Jan 15 | atGeorgia | L63-80 | 10-6 | .625 | - | ESPNU | Stegeman Coliseum · Athens, GA |
| 17 | Sat Jan 18 | atVanderbilt | W66-45 | 11-6 | .647 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 18 | Tue Jan 21 | vsOle Miss | W73-48 | 12-6 | .667 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 19 | Sat Jan 25 | atKansas | L68-74 | 12-7 | .632 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 20 | Tue Jan 28 | vsTexas A&M | L58-63 | 12-8 | .600 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 21 | Sat Feb 1 | atMississippi St | L73-86 | 12-9 | .571 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 22 | Tue Feb 4 | atAlabama | W69-68 | 13-9 | .591 | - | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 23 | Sat Feb 8 | vs15Kentucky | L64-77 | 13-10 | .565 | - | CBS | Thompson-Boling Arena · Knoxville, TN |
| 24 | Tue Feb 11 | vsArkansas | W82-61 | 14-10 | .583 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 25 | Sat Feb 15 | atSouth Carolina | L61-63 | 14-11 | .560 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 26 | Tue Feb 18 | vsVanderbilt | W65-61 | 15-11 | .577 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 27 | Sat Feb 22 | at13Auburn | L66-73 | 15-12 | .556 | - | CBS | Neville Arena · Auburn, AL |
| 28 | Wed Feb 26 | atArkansas | L69-86 | 15-13 | .536 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 29 | Sat Feb 29 | vsFlorida | W63-58 | 16-13 | .552 | - | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 30 | Tue Mar 3 | at6Kentucky | W81-73 | 17-13 | .567 | - | ESPN | Rupp Arena · Lexington, KY |
| 31 | Sat Mar 7 | vs17Auburn | L63-85 | 17-14 | .548 | - | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
