| 1 | Mon Nov 7 | vs Tennessee Tech | W75-43 | 1-0 | 1.000 | #11 | | Thompson-Boling Arena · Knoxville, TN |
| 2 | Sun Nov 13 | vs Colorado | L66-78 | 1-1 | .500 | #11 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 3 | Wed Nov 16 | vs FGCU | W81-50 | 2-1 | .667 | #22 | | Thompson-Boling Arena · Knoxville, TN |
| 4 | Wed Nov 23 | vs Butler | W71-45 | 3-1 | .750 | - | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 5 | Thu Nov 24 | at USC | W73-66 (OT) | 4-1 | .800 | - | ESPN2 | Galen Center · Los Angeles, CA |
| 6 | Fri Nov 25 | at Kansas | W64-50 | 5-1 | .833 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 7 | Wed Nov 30 | vs McNeese | W76-40 | 6-1 | .857 | #13 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 8 | Sun Dec 4 | vs Alcorn St | W94-40 | 7-1 | .875 | #13 | | Thompson-Boling Arena · Knoxville, TN |
| 9 | Wed Dec 7 | vs E Kentucky | W84-49 | 8-1 | .889 | #7 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 10 | Sun Dec 11 | at Maryland | W56-53 | 9-1 | .900 | - | FS1 | XFINITY Center · College Park, MD |
| 11 | Sat Dec 17 | at #9Arizona | L70-75 | 9-2 | .818 | #6 | ESPN2 | McKale Center · Tucson, AZ |
| 12 | Wed Dec 21 | vs Austin Peay | W86-44 | 10-2 | .833 | #8 | | Thompson-Boling Arena · Knoxville, TN |
| 13 | Wed Dec 28 | at Ole Miss | W63-59 | 11-2 | .846 | #7 | ESPNEWS | SJB Pavilion · Oxford, MS |
| 14 | Tue Jan 3 | vs Mississippi St | W87-53 | 12-2 | .857 | #8 | ESPNU | Thompson-Boling Arena · Knoxville, TN |
| 15 | Sat Jan 7 | at South Carolina | W85-42 | 13-2 | .867 | #8 | SEC Network | Colonial Life Arena · Columbia, SC |
| 16 | Tue Jan 10 | vs Vanderbilt | W77-68 | 14-2 | .875 | #5 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 17 | Sat Jan 14 | vs Kentucky | L56-63 | 14-3 | .824 | #5 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 18 | Tue Jan 17 | atMississippi St | W70-59 | 15-3 | .833 | #9 | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 19 | Sat Jan 21 | at LSU | W77-56 | 16-3 | .842 | #9 | ESPN | Pete Maravich Assembly Center · Baton Rouge, LA |
| 20 | Wed Jan 25 | vs Georgia | W70-41 | 17-3 | .850 | #4 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 21 | Sat Jan 28 | vs Texas | W82-71 | 18-3 | .857 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 22 | Wed Feb 1 | at Florida | L54-67 | 18-4 | .818 | #2 | ESPN2 | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 23 | Sat Feb 4 | vs #25Auburn | W46-43 | 19-4 | .826 | #2 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 24 | Wed Feb 8 | atVanderbilt | L65-66 | 19-5 | .792 | #6 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 11 | vs Missouri | L85-86 | 19-6 | .760 | #6 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 26 | Wed Feb 15 | vs #1Alabama | W68-59 | 20-6 | .769 | #10 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 27 | Sat Feb 18 | atKentucky | L54-66 | 20-7 | .741 | #10 | CBS | Rupp Arena · Lexington, KY |
| 28 | Tue Feb 21 | at #25Texas A&M | L63-68 | 20-8 | .714 | #11 | ESPN | Reed Arena · College Station, TX |
| 29 | Sat Feb 25 | vsSouth Carolina | W85-45 | 21-8 | .724 | #11 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 30 | Tue Feb 28 | vs Arkansas | W75-57 | 22-8 | .733 | #12 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 31 | Sat Mar 4 | atAuburn | L70-79 | 22-9 | .710 | #12 | ESPN | Neville Arena · Auburn, AL |
| 32 | Thu Mar 9 | vsOle Miss | W70-55 | 23-9 | .719 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 33 | Fri Mar 10 | atMissouri | L71-79 | 23-10 | .697 | - | ESPN | Mizzou Arena · Columbia, MO |
| 34 | Thu Mar 16 | vs #13Louisiana | W58-55 | 24-10 | .706 | #4 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 35 | Sat Mar 18 | vs #5Duke | W65-52 | 25-10 | .714 | #4 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 36 | Thu Mar 23 | vs #9FAU | L55-62 | 25-11 | .694 | #4 | TBS | Thompson-Boling Arena · Knoxville, TN |
