| 1 | Wed Nov 25 | vs E Michigan | W83-67 | 1-0 | 1.000 | #13 | BTN | Breslin Center · East Lansing, MI |
| 2 | Sat Nov 28 | vsNotre Dame | W80-70 | 2-0 | 1.000 | #13 | BTN | Breslin Center · East Lansing, MI |
| 3 | Tue Dec 1 | atDuke | W75-69 | 3-0 | 1.000 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 4 | Fri Dec 4 | vsDetroit Mercy | W83-76 | 4-0 | 1.000 | #8 | BTN | Breslin Center · East Lansing, MI |
| 5 | Sun Dec 6 | vsW Michigan | W79-61 | 5-0 | 1.000 | #8 | BTN | Breslin Center · East Lansing, MI |
| 7 | Sun Dec 13 | vsOakland | W109-91 | 6-0 | 1.000 | #4 | FS1 | Breslin Center · East Lansing, MI |
| 8 | Sun Dec 20 | atNorthwestern | L65-79 | 6-1 | .857 | #4 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 9 | Fri Dec 25 | vs9Wisconsin | L76-85 | 6-2 | .750 | #12 | FOX | Breslin Center · East Lansing, MI |
| 10 | Mon Dec 28 | at21Minnesota | L56-81 | 6-3 | .667 | #17 | BTN | Williams Arena · Minneapolis, MN |
| 11 | Sat Jan 2 | atNebraska | W84-77 | 7-3 | .700 | #17 | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 12 | Tue Jan 5 | vs15Rutgers | W68-45 | 8-3 | .727 | #23 | ESPN2 | Breslin Center · East Lansing, MI |
| 13 | Fri Jan 8 | vsPurdue | L54-55 | 8-4 | .667 | #23 | FS1 | Breslin Center · East Lansing, MI |
| 14 | Thu Jan 14 | at5Iowa | PPD | 15-13 | .536 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 15 | Sun Jan 17 | vsIndiana | PPD | 15-13 | .536 | - | | Breslin Center · East Lansing, MI |
| 16 | Sat Jan 23 | vs22Illinois | PPD | 15-13 | .536 | - | | Breslin Center · East Lansing, MI |
| 17 | Thu Jan 28 | atRutgers | L37-67 | 8-5 | .615 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 18 | Sun Jan 31 | at13Ohio State | L62-79 | 8-6 | .571 | - | CBS | Value City Arena · Columbus, OH |
| 19 | Tue Feb 2 | at8Iowa | L78-84 | 8-7 | .533 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 20 | Sat Feb 6 | vsNebraska | W66-56 | 9-7 | .563 | - | BTN | Breslin Center · East Lansing, MI |
| 21 | Tue Feb 9 | vsPenn State | W60-58 | 10-7 | .588 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 22 | Sat Feb 13 | vs15Iowa | L58-88 | 10-8 | .556 | - | FOX | Breslin Center · East Lansing, MI |
| 23 | Tue Feb 16 | atPurdue | L65-75 | 10-9 | .526 | - | ESPN | Mackey Arena · West Lafayette, IN |
| 24 | Sat Feb 20 | atIndiana | W78-71 | 11-9 | .550 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 25 | Tue Feb 23 | vs5Illinois | W81-72 | 12-9 | .571 | - | FS1 | Breslin Center · East Lansing, MI |
| 26 | Thu Feb 25 | vs4Ohio State | W71-67 | 13-9 | .591 | - | ESPN | Breslin Center · East Lansing, MI |
| 27 | Sun Feb 28 | atMaryland | L55-73 | 13-10 | .565 | - | CBS | XFINITY Center · College Park, MD |
| 28 | Tue Mar 2 | vsIndiana | W64-58 | 14-10 | .583 | - | BTN | Breslin Center · East Lansing, MI |
| 29 | Thu Mar 4 | at2Michigan | L50-69 | 14-11 | .560 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 30 | Sun Mar 7 | vs2Michigan | W70-64 | 15-11 | .577 | - | CBS | Breslin Center · East Lansing, MI |
| 31 | Thu Mar 11 | atMaryland | L57-68 | 15-12 | .556 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
| 31 | Thu Mar 18 | vs11UCLA | L80-86 (OT) | 15-13 | .536 | #11 | TBS | Mackey Arena · West Lafayette, IN |
