| 1 | Mon Nov 6 | vs JMU | L76-79 (OT) | 0-1 | .000 | #4 | BTN | Breslin Center · East Lansing, MI |
| 2 | Thu Nov 9 | vs So Indiana | W74-51 | 1-1 | .500 | #4 | BTN | Breslin Center · East Lansing, MI |
| 3 | Tue Nov 14 | vs #9Duke | L65-74 | 1-2 | .333 | #18 | ESPN | Breslin Center · East Lansing, MI |
| 4 | Fri Nov 17 | vs Butler | W74-54 | 2-2 | .500 | #18 | FS1 | Breslin Center · East Lansing, MI |
| 5 | Sun Nov 19 | vs Alcorn St | W81-49 | 3-2 | .600 | #18 | BTN | Breslin Center · East Lansing, MI |
| 6 | Thu Nov 23 | at #3Arizona | L68-74 | 3-3 | .500 | #21 | FOX | McKale Center · Tucson, AZ |
| 7 | Tue Nov 28 | vs Georgia So | W86-55 | 4-3 | .571 | - | BTN | Breslin Center · East Lansing, MI |
| 8 | Tue Dec 5 | vs #23Wisconsin | L57-70 | 4-4 | .500 | - | | Breslin Center · East Lansing, MI |
| 9 | Sun Dec 10 | at Nebraska | L70-77 | 4-5 | .444 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Sat Dec 16 | vs #6Baylor | W88-64 | 5-5 | .500 | - | FOX | Breslin Center · East Lansing, MI |
| 11 | Mon Dec 18 | vs Oakland | W79-62 | 6-5 | .545 | - | BTN | Breslin Center · East Lansing, MI |
| 12 | Thu Dec 21 | vs Stony Brook | W99-55 | 7-5 | .583 | - | | Breslin Center · East Lansing, MI |
| 13 | Sat Dec 30 | vs Indiana St | W87-75 | 8-5 | .615 | - | FS1 | Breslin Center · East Lansing, MI |
| 14 | Thu Jan 4 | vs Penn State | W92-61 | 9-5 | .643 | - | | Breslin Center · East Lansing, MI |
| 15 | Sun Jan 7 | at Northwestern | L74-88 | 9-6 | .600 | - | | Welsh-Ryan Arena · Evanston, IL |
| 16 | Thu Jan 11 | at #10Illinois | L68-71 | 9-7 | .563 | - | FS1 | State Farm Center · Champaign, IL |
| 17 | Sun Jan 14 | vs Rutgers | W73-55 | 10-7 | .588 | - | BTN | Breslin Center · East Lansing, MI |
| 18 | Thu Jan 18 | vs Minnesota | W76-66 | 11-7 | .611 | - | FS1 | Breslin Center · East Lansing, MI |
| 19 | Sun Jan 21 | at Maryland | W61-59 | 12-7 | .632 | - | CBS | XFINITY Center · College Park, MD |
| 20 | Fri Jan 26 | at#13Wisconsin | L66-81 | 12-8 | .600 | - | FS1 | Kohl Center · Madison, WI |
| 21 | Tue Jan 30 | vs Michigan | W81-62 | 13-8 | .619 | - | | Breslin Center · East Lansing, MI |
| 22 | Sat Feb 3 | vsMaryland | W63-54 | 14-8 | .636 | - | FOX | Breslin Center · East Lansing, MI |
| 23 | Tue Feb 6 | atMinnesota | L56-59 | 14-9 | .609 | - | | Williams Arena · Minneapolis, MN |
| 24 | Sat Feb 10 | vs#10Illinois | W88-80 | 15-9 | .625 | - | CBS | Breslin Center · East Lansing, MI |
| 25 | Wed Feb 14 | atPenn State | W80-72 | 16-9 | .640 | - | BTN | Bryce Jordan Center · University Park, PA |
| 26 | Sat Feb 17 | atMichigan | W73-63 | 17-9 | .654 | - | FOX | Crisler Center · Ann Arbor, MI |
| 27 | Tue Feb 20 | vs Iowa | L71-78 | 17-10 | .630 | - | | Breslin Center · East Lansing, MI |
| 28 | Sun Feb 25 | vs Ohio State | L57-60 | 17-11 | .607 | - | CBS | Breslin Center · East Lansing, MI |
| 29 | Sat Mar 2 | at #2Purdue | L74-80 | 17-12 | .586 | - | FOX | Mackey Arena · West Lafayette, IN |
| 30 | Wed Mar 6 | vsNorthwestern | W53-49 | 18-12 | .600 | - | BTN | Breslin Center · East Lansing, MI |
| 31 | Sun Mar 10 | at Indiana | L64-65 | 18-13 | .581 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 32 | Thu Mar 14 | vsMinnesota | W77-67 | 19-13 | .594 | - | BTN | Breslin Center · East Lansing, MI |
| 33 | Fri Mar 15 | at#3Purdue | L62-67 | 19-14 | .576 | - | BTN | Mackey Arena · West Lafayette, IN |
| 34 | Thu Mar 21 | at #8Mississippi St | W69-51 | 20-14 | .588 | #9 | CBS | Humphrey Coliseum · Starkville, MS |
| 35 | Sat Mar 23 | at #1UNC | L69-85 | 20-15 | .571 | #9 | CBS | Dean E. Smith Center · Chapel Hill, NC |
