| 1 | Tue Nov 9 | vs Kansas | L74-87 | 0-1 | .000 | - | ESPN | Breslin Center · East Lansing, MI |
| 2 | Fri Nov 12 | vs W Michigan | W90-46 | 1-1 | .500 | - | BTN | Breslin Center · East Lansing, MI |
| 3 | Wed Nov 17 | at Butler | W73-52 | 2-1 | .667 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Sat Nov 20 | vs E Michigan | W83-59 | 3-1 | .750 | - | | Breslin Center · East Lansing, MI |
| 5 | Wed Nov 24 | vs Loyola Chicago | W63-61 | 4-1 | .800 | - | ESPN | Breslin Center · East Lansing, MI |
| 6 | Thu Nov 25 | vs UConn | W64-60 | 5-1 | .833 | - | ESPN | Breslin Center · East Lansing, MI |
| 7 | Fri Nov 26 | vs Baylor | L58-75 | 5-2 | .714 | - | ESPN | Breslin Center · East Lansing, MI |
| 8 | Wed Dec 1 | vs Louisville | W73-64 | 6-2 | .750 | - | ESPN | Breslin Center · East Lansing, MI |
| 9 | Sat Dec 4 | vs Toledo | W81-68 | 7-2 | .778 | #22 | BTN | Breslin Center · East Lansing, MI |
| 10 | Wed Dec 8 | at Minnesota | W75-67 | 8-2 | .800 | #19 | BTN | Williams Arena · Minneapolis, MN |
| 11 | Sat Dec 11 | vs Penn State | W80-64 | 9-2 | .818 | #19 | BTN | Breslin Center · East Lansing, MI |
| 12 | Tue Dec 21 | at Oakland | W90-78 | 10-2 | .833 | #11 | | Athletics Center O'rena · Rochester, MI |
| 13 | Wed Dec 29 | vs High Point | W81-68 | 11-2 | .846 | #10 | BTN | Breslin Center · East Lansing, MI |
| 14 | Sun Jan 2 | at Northwestern | W73-67 | 12-2 | .857 | #10 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 15 | Wed Jan 5 | vs Nebraska | W79-67 | 13-2 | .867 | #10 | BTN | Breslin Center · East Lansing, MI |
| 16 | Sat Jan 8 | at Michigan | PPD | 23-13 | .639 | #10 | | Crisler Center · Ann Arbor, MI |
| 17 | Wed Jan 12 | vsMinnesota | W71-69 | 14-2 | .875 | #10 | BTN | Breslin Center · East Lansing, MI |
| 18 | Sat Jan 15 | vsNorthwestern | L62-64 | 14-3 | .824 | #10 | BTN | Breslin Center · East Lansing, MI |
| 19 | Fri Jan 21 | at #8Wisconsin | W86-74 | 15-3 | .833 | #14 | FS1 | Kohl Center · Madison, WI |
| 20 | Tue Jan 25 | at #24Illinois | L55-56 | 15-4 | .789 | #10 | ESPN | State Farm Center · Champaign, IL |
| 21 | Sat Jan 29 | vsMichigan | W83-67 | 16-4 | .800 | #10 | CBS | Breslin Center · East Lansing, MI |
| 22 | Tue Feb 1 | at Maryland | W65-63 | 17-4 | .810 | #13 | ESPN2 | XFINITY Center · College Park, MD |
| 23 | Sat Feb 5 | at Rutgers | L63-84 | 17-5 | .773 | #13 | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 24 | Tue Feb 8 | vs#14Wisconsin | L62-70 | 17-6 | .739 | #17 | BTN | Breslin Center · East Lansing, MI |
| 25 | Sat Feb 12 | vs Indiana | W76-61 | 18-6 | .750 | #17 | FOX | Breslin Center · East Lansing, MI |
| 26 | Tue Feb 15 | atPenn State | L58-62 | 18-7 | .720 | #19 | BTN | Bryce Jordan Center · University Park, PA |
| 27 | Sat Feb 19 | vs#12Illinois | L74-79 | 18-8 | .692 | #19 | ESPN | Breslin Center · East Lansing, MI |
| 28 | Tue Feb 22 | at #25Iowa | L60-86 | 18-9 | .667 | - | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 29 | Sat Feb 26 | vs #4Purdue | W68-65 | 19-9 | .679 | - | ESPN | Breslin Center · East Lansing, MI |
| 30 | Tue Mar 1 | atMichigan | L70-87 | 19-10 | .655 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 31 | Thu Mar 3 | at #23Ohio State | L69-80 | 19-11 | .633 | - | ESPN | Value City Arena · Columbus, OH |
| 32 | Sun Mar 6 | vsMaryland | W77-67 | 20-11 | .645 | - | CBS | Breslin Center · East Lansing, MI |
| 33 | Thu Mar 10 | vsMaryland | W76-72 | 21-11 | .656 | - | BTN | Breslin Center · East Lansing, MI |
| 34 | Fri Mar 11 | atWisconsin | W69-63 | 22-11 | .667 | - | BTN | Kohl Center · Madison, WI |
| 35 | Sat Mar 12 | atPurdue | L70-75 | 22-12 | .647 | - | CBS | Mackey Arena · West Lafayette, IN |
| 36 | Fri Mar 18 | vs #10Davidson | W74-73 | 23-12 | .657 | #7 | CBS | Breslin Center · East Lansing, MI |
| 37 | Sun Mar 20 | at #2Duke | L76-85 | 23-13 | .639 | #7 | CBS | Cameron Indoor Stadium · Durham, NC |
