| 1 | Tue Nov 5 | at Kentucky | L62-69 | 0-1 | .000 | - | ESPN | Rupp Arena · Lexington, KY |
| 2 | Sun Nov 10 | vs Binghamton | W100-47 | 1-1 | .500 | #1 | BTN | Breslin Center · East Lansing, MI |
| 3 | Thu Nov 14 | at Seton Hall | W76-73 | 2-1 | .667 | - | FS1 | Prudential Center · Newark, NJ |
| 4 | Mon Nov 18 | vs Charleston So | W94-46 | 3-1 | .750 | - | BTN | Breslin Center · East Lansing, MI |
| 5 | Mon Nov 25 | vs Virginia Tech | L66-71 | 3-2 | .600 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 6 | Tue Nov 26 | vs Georgia | W93-85 | 4-2 | .667 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 7 | Wed Nov 27 | at UCLA | W75-62 | 5-2 | .714 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 8 | Tue Dec 3 | vs Duke | L75-87 | 5-3 | .625 | - | ESPN | Breslin Center · East Lansing, MI |
| 9 | Sun Dec 8 | vs Rutgers | W77-65 | 6-3 | .667 | #11 | BTN | Breslin Center · East Lansing, MI |
| 10 | Sat Dec 14 | at Oakland | W72-49 | 7-3 | .700 | #16 | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 11 | Wed Dec 18 | at Northwestern | W77-72 | 8-3 | .727 | #15 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 12 | Sat Dec 21 | vs E Michigan | W101-48 | 9-3 | .750 | #15 | BTN | Breslin Center · East Lansing, MI |
| 13 | Sun Dec 29 | vs W Michigan | W95-62 | 10-3 | .769 | #14 | BTN | Breslin Center · East Lansing, MI |
| 14 | Thu Jan 2 | vs Illinois | W76-56 | 11-3 | .786 | #14 | FS1 | Breslin Center · East Lansing, MI |
| 15 | Sun Jan 5 | vs #12Michigan | W87-69 | 12-3 | .800 | #14 | CBS | Breslin Center · East Lansing, MI |
| 16 | Thu Jan 9 | vs Minnesota | W74-58 | 13-3 | .813 | #8 | ESPN2 | Breslin Center · East Lansing, MI |
| 17 | Sun Jan 12 | at Purdue | L42-71 | 13-4 | .765 | #8 | CBS | Mackey Arena · West Lafayette, IN |
| 18 | Fri Jan 17 | vs Wisconsin | W67-55 | 14-4 | .778 | #15 | FS1 | Breslin Center · East Lansing, MI |
| 19 | Thu Jan 23 | at Indiana | L63-67 | 14-5 | .737 | #11 | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 20 | Sun Jan 26 | atMinnesota | W70-52 | 15-5 | .750 | #11 | FOX | Williams Arena · Minneapolis, MN |
| 21 | Wed Jan 29 | vsNorthwestern | W79-50 | 16-5 | .762 | #14 | BTN | Breslin Center · East Lansing, MI |
| 22 | Sat Feb 1 | atWisconsin | L63-64 | 16-6 | .727 | #14 | FOX | Kohl Center · Madison, WI |
| 23 | Tue Feb 4 | vs #22Penn State | L70-75 | 16-7 | .696 | #16 | BTN | Breslin Center · East Lansing, MI |
| 24 | Sat Feb 8 | atMichigan | L68-77 | 16-8 | .667 | #16 | FOX | Crisler Center · Ann Arbor, MI |
| 25 | Tue Feb 11 | at#22Illinois | W70-69 | 17-8 | .680 | - | ESPN | State Farm Center · Champaign, IL |
| 26 | Sat Feb 15 | vs #9Maryland | L60-67 | 17-9 | .654 | - | ESPN | Breslin Center · East Lansing, MI |
| 27 | Thu Feb 20 | at Nebraska | W86-65 | 18-9 | .667 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 28 | Tue Feb 25 | vs #18Iowa | W78-70 | 19-9 | .679 | #24 | ESPN2 | Breslin Center · East Lansing, MI |
| 29 | Sat Feb 29 | at#9Maryland | W78-66 | 20-9 | .690 | #24 | ESPN | XFINITY Center · College Park, MD |
| 30 | Tue Mar 3 | at#20Penn State | W79-71 | 21-9 | .700 | #16 | ESPN | Bryce Jordan Center · University Park, PA |
| 31 | Sun Mar 8 | vs #19Ohio State | W80-69 | 22-9 | .710 | #16 | CBS | Breslin Center · East Lansing, MI |
