| 1 | Mon Nov 7 | vs N Arizona | W73-55 | 1-0 | 1.000 | - | | Breslin Center · East Lansing, MI |
| 2 | Fri Nov 11 | at Gonzaga | L63-64 | 1-1 | .500 | - | ESPN | McCarthey Athletic Center · Spokane, WA |
| 3 | Tue Nov 15 | vs Kentucky | W86-77 (2OT) | 2-1 | .667 | - | ESPN | Breslin Center · East Lansing, MI |
| 4 | Fri Nov 18 | vs Villanova | W73-71 | 3-1 | .750 | - | FS1 | Breslin Center · East Lansing, MI |
| 5 | Thu Nov 24 | vs Alabama | L70-81 | 3-2 | .600 | - | ESPN | Breslin Center · East Lansing, MI |
| 6 | Fri Nov 25 | vs Oregon | W74-70 | 4-2 | .667 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 7 | Sun Nov 27 | vs Portland | W78-77 | 5-2 | .714 | - | ESPN | Breslin Center · East Lansing, MI |
| 8 | Wed Nov 30 | at Notre Dame | L52-70 | 5-3 | .625 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 9 | Sun Dec 4 | vs Northwestern | L63-70 | 5-4 | .556 | #20 | BTN | Breslin Center · East Lansing, MI |
| 10 | Wed Dec 7 | at Penn State | W67-58 | 6-4 | .600 | - | BTN | Bryce Jordan Center · University Park, PA |
| 11 | Sat Dec 10 | vs Brown | W68-50 | 7-4 | .636 | - | BTN | Breslin Center · East Lansing, MI |
| 12 | Wed Dec 21 | vs Oakland | W67-54 | 8-4 | .667 | - | BTN | Breslin Center · East Lansing, MI |
| 13 | Fri Dec 30 | vs Buffalo | W89-68 | 9-4 | .692 | - | BTN | Breslin Center · East Lansing, MI |
| 14 | Tue Jan 3 | vs Nebraska | W74-56 | 10-4 | .714 | - | BTN | Breslin Center · East Lansing, MI |
| 15 | Sat Jan 7 | vs Michigan | W59-53 | 11-4 | .733 | - | FOX | Breslin Center · East Lansing, MI |
| 16 | Tue Jan 10 | at #18Wisconsin | W69-65 | 12-4 | .750 | - | ESPN | Kohl Center · Madison, WI |
| 17 | Fri Jan 13 | at Illinois | L66-75 | 12-5 | .706 | - | FS1 | State Farm Center · Champaign, IL |
| 18 | Mon Jan 16 | vs #3Purdue | L63-64 | 12-6 | .667 | - | FOX | Breslin Center · East Lansing, MI |
| 19 | Thu Jan 19 | vs #23Rutgers | W70-57 | 13-6 | .684 | - | FS1 | Breslin Center · East Lansing, MI |
| 20 | Sun Jan 22 | at Indiana | L69-82 | 13-7 | .650 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 21 | Thu Jan 26 | vs Iowa | W63-61 | 14-7 | .667 | - | FS1 | Breslin Center · East Lansing, MI |
| 22 | Sun Jan 29 | at#1Purdue | L61-77 | 14-8 | .636 | - | CBS | Mackey Arena · West Lafayette, IN |
| 23 | Sat Feb 4 | atRutgers | L55-61 | 14-9 | .609 | - | FOX | Jersey Mike’s Arena · Piscataway, NJ |
| 24 | Tue Feb 7 | vs Maryland | W63-58 | 15-9 | .625 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 25 | Sun Feb 12 | at Ohio State | W62-41 | 16-9 | .640 | - | CBS | Value City Arena · Columbus, OH |
| 27 | Sat Feb 18 | atMichigan | L72-84 | 16-10 | .615 | - | FOX | Crisler Center · Ann Arbor, MI |
| 28 | Tue Feb 21 | vs#17Indiana | W80-65 | 17-10 | .630 | - | ESPN | Breslin Center · East Lansing, MI |
| 29 | Sat Feb 25 | atIowa | L106-112 (OT) | 17-11 | .607 | - | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 30 | Tue Feb 28 | atNebraska | W80-67 | 18-11 | .621 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 31 | Sat Mar 4 | vsOhio State | W84-78 | 19-11 | .633 | - | ESPN | Breslin Center · East Lansing, MI |
| 32 | Fri Mar 10 | vsOhio State | L58-68 | 19-12 | .613 | - | BTN | Breslin Center · East Lansing, MI |
| 33 | Fri Mar 17 | vs #10USC | W72-62 | 20-12 | .625 | #7 | CBS | Breslin Center · East Lansing, MI |
| 34 | Sun Mar 19 | at #2Marquette | W69-60 | 21-12 | .636 | #7 | CBS | Fiserv Forum · Milwaukee, WI |
| 35 | Thu Mar 23 | at #3Kansas St | L93-98 (OT) | 21-13 | .618 | #7 | TBS | Bramlage Coliseum · Manhattan, KS |
