| 1 | Mon Nov 3 | vs Colgate | 7:00 PM | 14-19 | .424 | #22 | B1G+ | Breslin Center · East Lansing, MI |
| 2 | Sat Nov 8 | vs#14Arkansas | TBD | 22-14 | .611 | #22 | FOX | Breslin Center · East Lansing, MI |
| 3 | Thu Nov 13 | vsSan Jose St | TBD | 15-20 | .429 | #22 | | Breslin Center · East Lansing, MI |
| 4 | Tue Nov 18 | at#9Kentucky | 6:30 PM | 24-12 | .667 | #22 | ESPN | Rupp Arena · Lexington, KY |
| 5 | Fri Nov 21 | vsDetroit Mercy | TBD | 8-24 | .250 | #22 | | Breslin Center · East Lansing, MI |
| 6 | Tue Nov 25 | atE Carolina | 1:00 PM | 19-14 | .576 | #22 | FS2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 7 | Thu Nov 27 | vs#25UNC | 4:30 PM | 23-14 | .622 | #22 | FOX | Breslin Center · East Lansing, MI |
| 8 | Tue Dec 2 | vsIowa | TBD | 17-16 | .515 | #22 | | Breslin Center · East Lansing, MI |
| 9 | Sat Dec 6 | vs#6Duke | TBD | 35-4 | .897 | #22 | | Breslin Center · East Lansing, MI |
| 10 | Sat Dec 13 | atPenn State | 12:00 PM | 16-15 | .516 | #22 | BTN | Bryce Jordan Center · University Park, PA |
| 11 | Tue Dec 16 | vsToledo | TBD | 18-15 | .545 | #22 | | Breslin Center · East Lansing, MI |
| 12 | Sat Dec 20 | vsOakland | TBD | 16-18 | .471 | #22 | | Breslin Center · East Lansing, MI |
| 13 | Mon Dec 29 | vsCornell | TBD | 18-11 | .621 | #22 | | Breslin Center · East Lansing, MI |
| 14 | Fri Jan 2 | atNebraska | 9:00 PM | 21-14 | .600 | #22 | Peacock | Pinnacle Bank Arena · Lincoln, NE |
| 15 | Mon Jan 5 | vsUSC | 8:30 PM | 17-18 | .486 | #22 | | Breslin Center · East Lansing, MI |
| 16 | Thu Jan 8 | vsNorthwestern | TBD | 17-16 | .515 | #22 | | Breslin Center · East Lansing, MI |
| 17 | Tue Jan 13 | vsIndiana | TBD | 19-13 | .594 | #22 | | Breslin Center · East Lansing, MI |
| 18 | Sat Jan 17 | atWashington | TBD | 13-18 | .419 | #22 | | Alaska Airlines Arena · Seattle, WA |
| 19 | Tue Jan 20 | atOregon | TBD | 25-10 | .714 | #22 | | Matthew Knight Arena · Eugene, OR |
| 20 | Sat Jan 24 | vsMaryland | TBD | 27-9 | .750 | #22 | | Breslin Center · East Lansing, MI |
| 21 | Tue Jan 27 | atRutgers | TBD | 15-17 | .469 | #22 | | Jersey Mike’s Arena · Piscataway, NJ |
| 22 | Fri Jan 30 | vs#7Michigan | TBD | 27-10 | .730 | #22 | | Breslin Center · East Lansing, MI |
| 23 | Wed Feb 4 | atMinnesota | TBD | 15-17 | .469 | #22 | | Williams Arena · Minneapolis, MN |
| 24 | Sat Feb 7 | vs#17Illinois | 8:00 PM | 22-13 | .629 | #22 | | Breslin Center · East Lansing, MI |
| 25 | Fri Feb 13 | at#24Wisconsin | TBD | 27-10 | .730 | #22 | | Kohl Center · Madison, WI |
| 26 | Tue Feb 17 | vs#12UCLA | 8:30 PM | 23-11 | .676 | #22 | | Breslin Center · East Lansing, MI |
| 27 | Sun Feb 22 | vsOhio State | TBD | 17-15 | .531 | #22 | | Breslin Center · East Lansing, MI |
| 28 | Thu Feb 26 | at#1Purdue | TBD | 24-12 | .667 | #22 | | Mackey Arena · West Lafayette, IN |
| 29 | Sun Mar 1 | atIndiana | TBD | 19-13 | .594 | #22 | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 30 | Thu Mar 5 | vsRutgers | TBD | 15-17 | .469 | #22 | | Breslin Center · East Lansing, MI |
| 31 | Sun Mar 8 | at#7Michigan | TBD | 27-10 | .730 | #22 | | Crisler Center · Ann Arbor, MI |
