| 1 | Mon Nov 6 | vs Dartmouth | W92-54 | 1-0 | 1.000 | #2 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 2 | Fri Nov 10 | vs #12Arizona | L73-78 | 1-1 | .500 | #2 | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 3 | Tue Nov 14 | at #18Michigan St | W74-65 | 2-1 | .667 | #9 | ESPN | Breslin Center · East Lansing, MI |
| 4 | Fri Nov 17 | vs Bucknell | W90-60 | 3-1 | .750 | #9 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 5 | Tue Nov 21 | vs La Salle | W95-66 | 4-1 | .800 | #9 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 6 | Fri Nov 24 | vs So Indiana | W80-62 | 5-1 | .833 | #9 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 7 | Wed Nov 29 | at Arkansas | L75-80 | 5-2 | .714 | #7 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 8 | Sat Dec 2 | at Georgia Tech | L68-72 | 5-3 | .625 | #7 | | McCamish Pavilion · Atlanta, GA |
| 9 | Sat Dec 9 | vs Charlotte | W80-56 | 6-3 | .667 | #22 | The CW Network | Cameron Indoor Stadium · Durham, NC |
| 10 | Tue Dec 12 | vs Hofstra | W89-68 | 7-3 | .700 | #21 | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 11 | Wed Dec 20 | vs #10Baylor | W78-70 | 8-3 | .727 | #21 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 30 | vs Queens | W106-69 | 9-3 | .750 | #16 | The CW Network | Cameron Indoor Stadium · Durham, NC |
| 13 | Tue Jan 2 | vs Syracuse | W86-66 | 10-3 | .769 | #14 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 14 | Sat Jan 6 | at Notre Dame | W67-59 | 11-3 | .786 | #14 | ACC Network | Purcell Pavilion · South Bend, IN |
| 15 | Tue Jan 9 | at Pitt | W75-53 | 12-3 | .800 | #11 | ESPN | Petersen Events Center · Pittsburgh, PA |
| 16 | Sat Jan 13 | vsGeorgia Tech | W84-79 | 13-3 | .813 | #11 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 17 | Sat Jan 20 | vsPitt | L76-80 | 13-4 | .765 | #7 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 18 | Tue Jan 23 | at Louisville | W83-69 | 14-4 | .778 | #12 | ACC Network | KFC Yum! Center · Louisville, KY |
| 19 | Sat Jan 27 | vs Clemson | W72-71 | 15-4 | .789 | #12 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 20 | Mon Jan 29 | at Virginia Tech | W77-67 | 16-4 | .800 | #7 | ESPN | Cassell Coliseum · Blacksburg, VA |
| 21 | Sat Feb 3 | at #3UNC | L84-93 | 16-5 | .762 | #7 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 22 | Wed Feb 7 | vsNotre Dame | W71-53 | 17-5 | .773 | #9 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 23 | Sat Feb 10 | vs Boston College | W80-65 | 18-5 | .783 | #9 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 24 | Mon Feb 12 | vs Wake Forest | W77-69 | 19-5 | .792 | #9 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 25 | Sat Feb 17 | at Florida St | W76-67 | 20-5 | .800 | #9 | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Wed Feb 21 | at Miami | W84-55 | 21-5 | .808 | #8 | ESPN | Watsco Center · Coral Gables, FL |
| 27 | Sat Feb 24 | atWake Forest | L79-83 | 21-6 | .778 | #8 | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 28 | Wed Feb 28 | vsLouisville | W84-59 | 22-6 | .786 | #10 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 29 | Sat Mar 2 | vs Virginia | W73-48 | 23-6 | .793 | #10 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 30 | Mon Mar 4 | at NC State | W79-64 | 24-6 | .800 | #9 | ESPN | PNC Arena · Raleigh, NC |
| 31 | Sat Mar 9 | vs#7UNC | L79-84 | 24-7 | .774 | #9 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 32 | Thu Mar 14 | vsNC State | L69-74 | 24-8 | .750 | #11 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 33 | Fri Mar 22 | vs #13Vermont | W64-47 | 25-8 | .758 | #4 | CBS | Cameron Indoor Stadium · Durham, NC |
| 34 | Sun Mar 24 | vs #12JMU | W93-55 | 26-8 | .765 | #4 | CBS | Cameron Indoor Stadium · Durham, NC |
| 35 | Fri Mar 29 | at #1Houston | W54-51 | 27-8 | .771 | #4 | CBS | Fertitta Center · Houston, TX |
| 36 | Sun Mar 31 | vs#11NC State | L64-76 | 27-9 | .750 | #4 | CBS | Cameron Indoor Stadium · Durham, NC |
