| 1 | Tue Nov 5 | vs Kansas | W68-66 | 1-0 | 1.000 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 2 | Fri Nov 8 | vsColorado St | W89-55 | 2-0 | 1.000 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 3 | Tue Nov 12 | vsC Arkansas | W105-54 | 3-0 | 1.000 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 4 | Fri Nov 15 | vsGeorgia St | W74-63 | 4-0 | 1.000 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 5 | Thu Nov 21 | atCalifornia | W87-52 | 5-0 | 1.000 | - | ESPN2 | Haas Pavilion · Berkeley, CA |
| 6 | Fri Nov 22 | atGeorgetown | W81-73 | 6-0 | 1.000 | - | ESPN2 | Capital One Arena · Washington, D.C. |
| 7 | Tue Nov 26 | vsSF Austin | L83-85 (OT) | 6-1 | .857 | #1 | | Cameron Indoor Stadium · Durham, NC |
| 8 | Fri Nov 29 | vsWinthrop | W83-70 | 7-1 | .875 | #1 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 9 | Tue Dec 3 | atMichigan St | W87-75 | 8-1 | .889 | - | ESPN | Breslin Center · East Lansing, MI |
| 10 | Fri Dec 6 | atVirginia Tech | W77-63 | 9-1 | .900 | #10 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 11 | Thu Dec 19 | vsWofford | W86-57 | 10-1 | .909 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 28 | vsBrown | W75-50 | 11-1 | .917 | #4 | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 13 | Tue Dec 31 | vsBoston College | W88-49 | 12-1 | .923 | #2 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 14 | Sat Jan 4 | atMiami | W95-62 | 13-1 | .929 | #2 | ESPN | Watsco Center · Coral Gables, FL |
| 15 | Wed Jan 8 | atGeorgia Tech | W73-64 | 14-1 | .933 | #2 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 16 | Sat Jan 11 | vsWake Forest | W90-59 | 15-1 | .938 | #2 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 17 | Tue Jan 14 | atClemson | L72-79 | 15-2 | .882 | #3 | ESPN | Littlejohn Coliseum · Clemson, SC |
| 18 | Sat Jan 18 | vs11Louisville | L73-79 | 15-3 | .833 | #3 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 19 | Tue Jan 21 | vsMiami | W89-59 | 16-3 | .842 | #8 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 20 | Tue Jan 28 | vsPitt | W79-67 | 17-3 | .850 | #9 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Feb 1 | atSyracuse | W97-88 | 18-3 | .857 | #9 | ESPN | JMA Wireless Dome · Syracuse, NY |
| 22 | Tue Feb 4 | atBoston College | W63-55 | 19-3 | .864 | #7 | ESPN | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Sat Feb 8 | atUNC | W98-96 (OT) | 20-3 | .870 | #7 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Mon Feb 10 | vs8Florida St | W70-65 | 21-3 | .875 | #7 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 25 | Sat Feb 15 | vsNotre Dame | W94-60 | 22-3 | .880 | #7 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Wed Feb 19 | atNC State | L66-88 | 22-4 | .846 | #6 | ESPN | PNC Arena · Raleigh, NC |
| 27 | Sat Feb 22 | vsVirginia Tech | W88-64 | 23-4 | .852 | #6 | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 28 | Tue Feb 25 | atWake Forest | L101-113 (2OT) | 23-5 | .821 | #7 | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 29 | Sat Feb 29 | atVirginia | L50-52 | 23-6 | .793 | #7 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 30 | Mon Mar 2 | vsNC State | W88-69 | 24-6 | .800 | #12 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 31 | Sat Mar 7 | vsUNC | W89-76 | 25-6 | .806 | #12 | ESPN | Cameron Indoor Stadium · Durham, NC |
