| 1 | Mon Nov 7 | vs Jacksonville | W71-44 | 1-0 | 1.000 | #7 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 2 | Fri Nov 11 | vs SC Upstate | W84-38 | 2-0 | 1.000 | #7 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 3 | Tue Nov 15 | at Kansas | L64-69 | 2-1 | .667 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 4 | Fri Nov 18 | vs Delaware | W92-58 | 3-1 | .750 | #7 | | Cameron Indoor Stadium · Durham, NC |
| 5 | Mon Nov 21 | vs Bellarmine | W74-57 | 4-1 | .800 | #8 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 6 | Thu Nov 24 | at Oregon St | W54-51 | 5-1 | .833 | - | ESPN | Gill Coliseum · Corvallis, OR |
| 7 | Fri Nov 25 | at Xavier | W71-64 | 6-1 | .857 | - | ESPN | Cintas Center · Cincinnati, OH |
| 8 | Sun Nov 27 | at Purdue | L56-75 | 6-2 | .750 | - | ABC | Mackey Arena · West Lafayette, IN |
| 9 | Wed Nov 30 | vs Ohio State | W81-72 | 7-2 | .778 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 10 | Sat Dec 3 | vs Boston College | W75-59 | 8-2 | .800 | #17 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 11 | Tue Dec 6 | vs Iowa | W74-62 | 9-2 | .818 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 10 | vs MD-Eastern | W82-55 | 10-2 | .833 | #15 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 13 | Tue Dec 20 | at Wake Forest | L70-81 | 10-3 | .769 | #14 | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 14 | Sat Dec 31 | vs Florida St | W86-67 | 11-3 | .786 | #17 | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 15 | Wed Jan 4 | at NC State | L60-84 | 11-4 | .733 | #16 | ACC Network | PNC Arena · Raleigh, NC |
| 16 | Sat Jan 7 | atBoston College | W65-64 | 12-4 | .750 | #16 | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 17 | Wed Jan 11 | vs Pitt | W77-69 | 13-4 | .765 | #24 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 18 | Sat Jan 14 | at Clemson | L64-72 | 13-5 | .722 | #24 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Sat Jan 21 | vs #17Miami | W68-66 | 14-5 | .737 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 20 | Mon Jan 23 | at Virginia Tech | L75-78 | 14-6 | .700 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 21 | Sat Jan 28 | at Georgia Tech | W86-43 | 15-6 | .714 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 22 | Tue Jan 31 | vsWake Forest | W75-73 | 16-6 | .727 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 23 | Sat Feb 4 | vs UNC | W63-57 | 17-6 | .739 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 24 | Mon Feb 6 | at#19Miami | L59-81 | 17-7 | .708 | - | ESPN | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 11 | at Virginia | L62-69 (OT) | 17-8 | .680 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 26 | Tue Feb 14 | vs Notre Dame | W68-64 | 18-8 | .692 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Sat Feb 18 | at Syracuse | W77-55 | 19-8 | .704 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 28 | Mon Feb 20 | vs Louisville | W79-62 | 20-8 | .714 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 29 | Sat Feb 25 | vsVirginia Tech | W81-65 | 21-8 | .724 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 30 | Tue Feb 28 | vsNC State | W71-67 | 22-8 | .733 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 31 | Sat Mar 4 | atUNC | W62-57 | 23-8 | .742 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 32 | Thu Mar 9 | vsPitt | W96-69 | 24-8 | .750 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 33 | Fri Mar 10 | atMiami | W85-78 | 25-8 | .758 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 34 | Sat Mar 11 | atVirginia | W59-49 | 26-8 | .765 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 35 | Thu Mar 16 | vs #12Oral Roberts | W74-51 | 27-8 | .771 | #5 | CBS | Cameron Indoor Stadium · Durham, NC |
| 36 | Sat Mar 18 | at #4Tennessee | L52-65 | 27-9 | .750 | #5 | CBS | Thompson-Boling Arena · Knoxville, TN |
