| 1 | Wed Nov 25 | vs Gardner-Webb | PPD | 13-11 | .542 | #9 | | Cameron Indoor Stadium · Durham, NC |
| 2 | Sat Nov 28 | vsCoppin St | W81-71 | 1-0 | 1.000 | #9 | | Cameron Indoor Stadium · Durham, NC |
| 3 | Tue Dec 1 | vsMichigan St | L69-75 | 1-1 | .500 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 4 | Fri Dec 4 | vsBellarmine | W76-54 | 2-1 | .667 | - | | Cameron Indoor Stadium · Durham, NC |
| 6 | Tue Dec 8 | vsIllinois | L68-83 | 2-2 | .500 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 8 | Wed Dec 16 | atNotre Dame | W75-65 | 3-2 | .600 | - | ESPN | Purcell Pavilion · South Bend, IN |
| 12 | Wed Jan 6 | vsBoston College | W83-82 | 4-2 | .667 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 13 | Sat Jan 9 | vsWake Forest | W79-68 | 5-2 | .714 | #21 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 14 | Tue Jan 12 | at#20Virginia Tech | L67-74 | 5-3 | .625 | #19 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 15 | Tue Jan 19 | atPitt | L73-79 | 5-4 | .556 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 16 | Sat Jan 23 | atLouisville | L65-70 | 5-5 | .500 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 17 | Tue Jan 26 | vsGeorgia Tech | W75-68 | 6-5 | .545 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 18 | Sat Jan 30 | vsClemson | W79-53 | 7-5 | .583 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 19 | Mon Feb 1 | atMiami | L75-77 | 7-6 | .538 | - | ESPN | Watsco Center · Coral Gables, FL |
| 20 | Sat Feb 6 | vsUNC | L87-91 | 7-7 | .500 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Tue Feb 9 | vsNotre Dame | L89-93 | 7-8 | .467 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 22 | Sat Feb 13 | atNC State | W69-53 | 8-8 | .500 | - | ESPN | PNC Arena · Raleigh, NC |
| 23 | Wed Feb 17 | atWake Forest | W84-60 | 9-8 | .529 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 24 | Sat Feb 20 | vs#7Virginia | W66-65 | 10-8 | .556 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 25 | Mon Feb 22 | vsSyracuse | W85-71 | 11-8 | .579 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Sat Feb 27 | vsLouisville | L73-80 (OT) | 11-9 | .550 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Tue Mar 2 | atGeorgia Tech | L77-81 (OT) | 11-10 | .524 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 28 | Sat Mar 6 | atUNC | L73-91 | 11-11 | .500 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Tue Mar 9 | vsBoston College | W86-51 | 12-11 | .522 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
| 30 | Wed Mar 10 | atLouisville | W70-56 | 13-11 | .542 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
