| 1 | Wed Nov 25 | at Clemson | L42-53 | 0-1 | .000 | - | CBS | Littlejohn Coliseum · Clemson, SC |
| 2 | Thu Nov 26 | vs Liberty | L73-84 | 0-2 | .000 | - | CBS | Humphrey Coliseum · Starkville, MS |
| 3 | Mon Nov 30 | vs Texas St | W68-51 | 1-2 | .333 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 4 | Fri Dec 4 | vs North Texas | W69-63 | 2-2 | .500 | - | | Humphrey Coliseum · Starkville, MS |
| 5 | Tue Dec 8 | vs Jackson St | W82-59 | 3-2 | .600 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 6 | Sat Dec 12 | at Dayton | L82-85 (2OT) | 3-3 | .500 | - | ESPNU | UD Arena · Dayton, OH |
| 7 | Wed Dec 16 | vs C Arkansas | W81-65 | 4-3 | .571 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 8 | Mon Dec 21 | vs Miss Valley St | W87-48 | 5-3 | .625 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 9 | Wed Dec 30 | at Georgia | W83-73 | 6-3 | .667 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 10 | Sat Jan 2 | vs Kentucky | L73-78 (2OT) | 6-4 | .600 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 11 | Tue Jan 5 | vs #13Missouri | W78-63 | 7-4 | .636 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 12 | Sat Jan 9 | at Vanderbilt | W84-81 | 8-4 | .667 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 13 | Wed Jan 13 | vs Texas A&M | L55-56 | 8-5 | .615 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 14 | Sat Jan 16 | vs Florida | W72-69 | 9-5 | .643 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 15 | Tue Jan 19 | vs Ole Miss | L46-64 | 9-6 | .600 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 16 | Sat Jan 23 | at #18Alabama | L73-81 | 9-7 | .563 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 17 | Tue Jan 26 | at #18Tennessee | L53-56 | 9-8 | .529 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 18 | Sat Jan 30 | vs Iowa State | W95-56 | 10-8 | .556 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 19 | Tue Feb 2 | at Arkansas | L45-61 | 10-9 | .526 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 20 | Sat Feb 6 | at South Carolina | W75-59 | 11-9 | .550 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 21 | Wed Feb 10 | vs LSU | L80-94 | 11-10 | .524 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 22 | Sat Feb 13 | vsVanderbilt | L51-72 | 11-11 | .500 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 23 | Thu Feb 18 | at Auburn | PPD | 18-15 | .545 | - | ESPNU | Neville Arena · Auburn, AL |
| 24 | Sat Feb 20 | atOle Miss | W66-56 | 12-11 | .522 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 25 | Wed Feb 24 | vsSouth Carolina | W69-48 | 13-11 | .542 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 26 | Sat Feb 27 | vs#6Alabama | L59-64 | 13-12 | .520 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 27 | Wed Mar 3 | atTexas A&M | W63-57 | 14-12 | .538 | - | SEC Network | Reed Arena · College Station, TX |
| 28 | Sat Mar 6 | atAuburn | L71-78 | 14-13 | .519 | - | SEC Network | Neville Arena · Auburn, AL |
| 29 | Thu Mar 11 | atKentucky | W74-73 | 15-13 | .536 | - | SEC Network | Rupp Arena · Lexington, KY |
| 30 | Fri Mar 12 | atAlabama | L48-85 | 15-14 | .517 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 31 | Sat Mar 20 | at #1Saint Louis | W74-68 | 16-14 | .533 | #4 | ESPN | Chaifetz Arena · St. Louis, MO |
| 32 | Thu Mar 25 | at #2Richmond | W68-67 | 17-14 | .548 | #4 | ESPN2 | Robins Center · Richmond, VA |
| 33 | Sat Mar 27 | vs #4Louisiana Tech | W84-62 | 18-14 | .563 | #4 | ESPN | Humphrey Coliseum · Starkville, MS |
| 34 | Sun Mar 28 | at #1Memphis | L64-77 | 18-15 | .545 | #4 | ESPN | FedExForum · Memphis, TN |
