| 1 | Tue Nov 5 | vs FIU | W77-69 | 1-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 2 | Fri Nov 8 | vs Sam Houston | W67-58 | 2-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 3 | Thu Nov 14 | vs UL Monroe | W62-45 | 3-0 | 1.000 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 4 | Sun Nov 17 | vs New Orleans | W82-59 | 4-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 5 | Thu Nov 21 | at Tulane | W80-66 | 5-0 | 1.000 | - | ESPNU | Devlin Fieldhouse · New Orleans, LA |
| 6 | Fri Nov 22 | vs Villanova | L76-83 | 5-1 | .833 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 7 | Sun Nov 24 | at Coast Car | W81-56 | 6-1 | .857 | - | ESPNEWS | The HTC Center · Conway, SC |
| 8 | Thu Dec 5 | vs Louisiana Tech | L67-74 | 6-2 | .750 | - | | Humphrey Coliseum · Starkville, MS |
| 9 | Sat Dec 14 | at Kansas St | W67-61 | 7-2 | .778 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 10 | Wed Dec 18 | vs Radford | W77-68 | 8-2 | .800 | - | | Humphrey Coliseum · Starkville, MS |
| 11 | Sun Dec 22 | vs New Mexico St | L52-58 | 8-3 | .727 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 12 | Mon Dec 30 | vs Kent State | W96-68 | 9-3 | .750 | - | | Humphrey Coliseum · Starkville, MS |
| 13 | Sat Jan 4 | vs #8Auburn | L68-80 | 9-4 | .692 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 14 | Wed Jan 8 | at Alabama | L69-90 | 9-5 | .643 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Sat Jan 11 | at LSU | L59-60 | 9-6 | .600 | - | ESPN | Pete Maravich Assembly Center · Baton Rouge, LA |
| 16 | Tue Jan 14 | vs Missouri | W72-45 | 10-6 | .625 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Sat Jan 18 | vs Georgia | W91-59 | 11-6 | .647 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 18 | Wed Jan 22 | vs Arkansas | W77-70 | 12-6 | .667 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 19 | Sat Jan 25 | at Oklahoma | L62-63 | 12-7 | .632 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 20 | Tue Jan 28 | at Florida | W78-71 | 13-7 | .650 | - | ESPN2 | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 21 | Sat Feb 1 | vs Tennessee | W86-73 | 14-7 | .667 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 22 | Tue Feb 4 | at #15Kentucky | L72-80 | 14-8 | .636 | - | ESPN | Rupp Arena · Lexington, KY |
| 23 | Sat Feb 8 | vs Vanderbilt | W80-70 | 15-8 | .652 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 24 | Tue Feb 11 | at Ole Miss | L58-83 | 15-9 | .625 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 25 | Sat Feb 15 | atArkansas | W78-77 | 16-9 | .640 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 26 | Wed Feb 19 | vs South Carolina | W79-76 | 17-9 | .654 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 22 | at Texas A&M | L75-87 | 17-10 | .630 | - | SEC Network | Reed Arena · College Station, TX |
| 28 | Tue Feb 25 | vsAlabama | W80-73 | 18-10 | .643 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 29 | Sat Feb 29 | atMissouri | W67-63 | 19-10 | .655 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 30 | Tue Mar 3 | atSouth Carolina | L71-83 | 19-11 | .633 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 31 | Sat Mar 7 | vsOle Miss | W69-44 | 20-11 | .645 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
