| 1 | Wed Nov 5 | vs North Alabama | W86-62 | 1-0 | 1.000 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 2 | Mon Nov 10 | at16Iowa State | L80-96 | 1-1 | .500 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 3 | Sat Nov 15 | vsSE Louisiana | W75-68 | 2-1 | .667 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 4 | Thu Nov 20 | atKansas St | L77-98 | 2-2 | .500 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 5 | Fri Nov 21 | atNew Mexico | L78-80 | 2-3 | .400 | - | Peacock | The Pit · Albuquerque, NM |
| 6 | Mon Nov 24 | vsNew Orleans | W81-78 (OT) | 3-3 | .500 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 7 | Fri Nov 28 | vsSMU | L81-87 (OT) | 3-4 | .429 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 8 | Wed Dec 3 | atGeorgia Tech | W85-73 | 4-4 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 9 | Sun Dec 7 | vsSan Francisco | L62-65 | 4-5 | .444 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 10 | Sat Dec 13 | atUtah | W82-74 | 5-5 | .500 | - | ESPNU | Delta Center · Salt Lake City, UT |
| 11 | Tue Dec 16 | vsLong Island | W87-83 | 6-5 | .545 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 12 | Sat Dec 20 | vsMemphis | W71-66 | 7-5 | .583 | - | ESPN | Humphrey Coliseum · Starkville, MS |
| 13 | Mon Dec 29 | vsAlabama St | W94-56 | 8-5 | .615 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 14 | Sat Jan 3 | atTexas | W101-98 (OT) | 9-5 | .643 | - | SEC Network | Moody Center · Austin, TX |
| 15 | Wed Jan 7 | vsOklahoma | W72-53 | 10-5 | .667 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 16 | Sat Jan 10 | atKentucky | L68-92 | 10-6 | .625 | - | SEC Network | Rupp Arena · Lexington, KY |
| 17 | Tue Jan 13 | vs18Alabama | L82-97 | 10-7 | .588 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 18 | Sat Jan 17 | vsOle Miss | L67-68 | 10-8 | .556 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 19 | Wed Jan 21 | atTexas A&M | L68-88 | 10-9 | .526 | - | SEC Network | Reed Arena · College Station, TX |
| 20 | Sat Jan 24 | vs15Vanderbilt | L56-88 | 10-10 | .500 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 21 | Wed Jan 28 | atLSU | W80-66 | 11-10 | .524 | - | SECN+ | Pete Maravich Assembly Center · Baton Rouge, LA |
| 22 | Sat Jan 31 | atMissouri | L79-84 | 11-11 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 23 | Sat Feb 7 | vs21Arkansas | L68-88 | 11-12 | .478 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 24 | Wed Feb 11 | vsTennessee | L64-73 | 11-13 | .458 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 25 | Sat Feb 14 | atOle Miss | W90-78 | 12-13 | .480 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 26 | Wed Feb 18 | vsAuburn | W91-85 | 13-13 | .500 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 21 | atSouth Carolina | L89-97 | 13-14 | .481 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 28 | Wed Feb 25 | at17Alabama | L75-100 | 13-15 | .464 | - | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 29 | Sat Feb 28 | vsMissouri | L64-88 | 13-16 | .448 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
