| 1 | Wed Nov 5 | vs North Alabama | 9:00 PM | 24-11 | .686 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 2 | Mon Nov 10 | at#16Iowa State | 8:00 PM | 25-10 | .714 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 3 | Sat Nov 15 | vsSE Louisiana | 3:00 PM | 18-14 | .563 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 4 | Thu Nov 20 | atKansas St | 9:30 PM | 16-17 | .485 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 5 | Mon Nov 24 | vsNew Orleans | 7:30 PM | 4-27 | .129 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 6 | Fri Nov 28 | vsSMU | 7:00 PM | 24-11 | .686 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 7 | Wed Dec 3 | atGeorgia Tech | 9:00 PM | 17-17 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 8 | Sun Dec 7 | vsSan Francisco | 4:00 PM | 25-10 | .714 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 9 | Sat Dec 13 | vsUtah | 10:00 PM | 16-17 | .485 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 10 | Tue Dec 16 | vsLong Island | TBD | 17-16 | .515 | - | | Humphrey Coliseum · Starkville, MS |
| 11 | Sat Dec 20 | vsMemphis | 2:00 PM | 29-6 | .829 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 12 | Mon Dec 29 | vsAlabama St | TBD | 20-16 | .556 | - | | Humphrey Coliseum · Starkville, MS |
| 13 | Sat Jan 3 | atTexas | 6:00 PM | 19-16 | .543 | - | SEC Network | Moody Center · Austin, TX |
| 14 | Wed Jan 7 | vsOklahoma | 7:00 PM | 20-14 | .588 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 15 | Sat Jan 10 | at#9Kentucky | 8:30 PM | 24-12 | .667 | - | SEC Network | Rupp Arena · Lexington, KY |
| 16 | Tue Jan 13 | vs#15Alabama | 9:00 PM | 28-9 | .757 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Sat Jan 17 | vsOle Miss | 8:30 PM | 24-12 | .667 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 18 | Wed Jan 21 | atTexas A&M | 9:00 PM | 23-11 | .676 | - | SEC Network | Reed Arena · College Station, TX |
| 19 | Sat Jan 24 | vsVanderbilt | 6:00 PM | 20-13 | .606 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 20 | Wed Jan 28 | atLSU | 7:00 PM | 14-18 | .438 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 21 | Sat Jan 31 | atMissouri | 3:30 PM | 22-12 | .647 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 22 | Sat Feb 7 | vs#14Arkansas | TBD | 22-14 | .611 | - | | Humphrey Coliseum · Starkville, MS |
| 23 | Wed Feb 11 | vs#18Tennessee | TBD | 30-8 | .789 | - | | Humphrey Coliseum · Starkville, MS |
| 24 | Sat Feb 14 | atOle Miss | TBD | 24-12 | .667 | - | | SJB Pavilion · Oxford, MS |
| 25 | Wed Feb 18 | vs#20Auburn | 9:00 PM | 32-6 | .842 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 26 | Sat Feb 21 | atSouth Carolina | 1:00 PM | 12-20 | .375 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 27 | Tue Feb 24 | at#15Alabama | TBD | 28-9 | .757 | - | | Coleman Coliseum · Tuscaloosa, AL |
| 28 | Sat Feb 28 | vsMissouri | 1:00 PM | 22-12 | .647 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 29 | Tue Mar 3 | at#3Florida | 8:00 PM | 36-4 | .900 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 30 | Sat Mar 7 | vsGeorgia | 3:30 PM | 20-13 | .606 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
