| 1 | Mon Nov 7 | vs Texas A&M-CC | W63-44 | 1-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 2 | Fri Nov 11 | atAkron | W73-54 | 2-0 | 1.000 | - | | James A. Rhodes Arena · Akron, OH |
| 3 | Sun Nov 13 | vsAR-Pine Bluff | W80-47 | 3-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 4 | Thu Nov 17 | vsSouth Dakota | W79-42 | 4-0 | 1.000 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 5 | Mon Nov 21 | vsMarquette | W58-55 | 5-0 | 1.000 | - | FS1 | Humphrey Coliseum · Starkville, MS |
| 6 | Wed Nov 23 | vsUtah | W52-49 | 6-0 | 1.000 | - | FS1 | Humphrey Coliseum · Starkville, MS |
| 7 | Mon Nov 28 | vsOmaha | W74-54 | 7-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 8 | Sat Dec 3 | vsMiss Valley St | W82-52 | 8-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 9 | Sun Dec 11 | atMinnesota | W69-51 | 9-0 | 1.000 | #23 | BTN | Williams Arena · Minneapolis, MN |
| 10 | Wed Dec 14 | atJackson St | W69-59 | 10-0 | 1.000 | #17 | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 11 | Sat Dec 17 | vsNicholls | W68-66 | 11-0 | 1.000 | #17 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 12 | Tue Dec 20 | atDrake | L52-58 | 11-1 | .917 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 13 | Wed Dec 28 | vs#8Alabama | L67-78 | 11-2 | .846 | #21 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 14 | Tue Jan 3 | at#8Tennessee | L53-87 | 11-3 | .786 | - | ESPNU | Thompson-Boling Arena · Knoxville, TN |
| 15 | Sat Jan 7 | vsOle Miss | W64-54 | 12-3 | .800 | - | CBS | Humphrey Coliseum · Starkville, MS |
| 16 | Wed Jan 11 | atGeorgia | L50-58 | 12-4 | .750 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 17 | Sat Jan 14 | at#21Auburn | L63-69 | 12-5 | .706 | - | SEC Network | Neville Arena · Auburn, AL |
| 18 | Tue Jan 17 | vs#9Tennessee | L59-70 | 12-6 | .667 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 19 | Sat Jan 21 | vsFlorida | L59-61 | 12-7 | .632 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 20 | Wed Jan 25 | at#2Alabama | L63-66 | 12-8 | .600 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 21 | Sat Jan 28 | vsTCU | W81-74 (OT) | 13-8 | .619 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 22 | Tue Jan 31 | atSouth Carolina | W66-51 | 14-8 | .636 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 23 | Sat Feb 4 | vsMissouri | W63-52 | 15-8 | .652 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 24 | Wed Feb 8 | vsLSU | W64-53 | 16-8 | .667 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 25 | Sat Feb 11 | atArkansas | W70-64 | 17-8 | .680 | - | ESPNU | Bud Walton Arena · Fayetteville, AR |
| 26 | Wed Feb 15 | vsKentucky | L68-71 | 17-9 | .654 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 18 | atOle Miss | W69-61 (OT) | 18-9 | .667 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 28 | Tue Feb 21 | atMissouri | L64-66 (OT) | 18-10 | .643 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 29 | Sat Feb 25 | vs#25Texas A&M | W69-62 | 19-10 | .655 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 30 | Tue Feb 28 | vsSouth Carolina | W74-68 | 20-10 | .667 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 31 | Sat Mar 4 | atVanderbilt | L72-77 | 20-11 | .645 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 32 | Thu Mar 9 | atFlorida | W69-68 (OT) | 21-11 | .656 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 33 | Fri Mar 10 | atAlabama | L49-72 | 21-12 | .636 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 34 | Tue Mar 14 | vs#11Pitt | L59-60 | 21-13 | .618 | #11 | truTV | UD Arena · Dayton, OH |
