| 1 | Wed Nov 8 | vs Arizona St | W71-56 | 1-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 2 | Sat Nov 11 | vs UT Martin | W87-63 | 2-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 3 | Tue Nov 14 | vs North Alabama | W81-54 | 3-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 4 | Sat Nov 18 | vs Washington St | W76-64 | 4-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 5 | Sun Nov 19 | vs Northwestern | W66-57 | 5-0 | 1.000 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 6 | Fri Nov 24 | vs Nicholls | W74-61 | 6-0 | 1.000 | #25 | | Humphrey Coliseum · Starkville, MS |
| 7 | Tue Nov 28 | at Georgia Tech | L59-67 | 6-1 | .857 | #21 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 8 | Sun Dec 3 | vs Southern | L59-60 | 6-2 | .750 | #21 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 9 | Sat Dec 9 | vs Tulane | W106-76 | 7-2 | .778 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 10 | Wed Dec 13 | vs Murray St | W85-81 | 8-2 | .800 | - | | Humphrey Coliseum · Starkville, MS |
| 11 | Sun Dec 17 | vs North Texas | W72-54 | 9-2 | .818 | - | | Humphrey Coliseum · Starkville, MS |
| 12 | Sat Dec 23 | vs Rutgers | W70-60 | 10-2 | .833 | - | BTN | Humphrey Coliseum · Starkville, MS |
| 13 | Sun Dec 31 | vs Bethune | W85-62 | 11-2 | .846 | - | | Humphrey Coliseum · Starkville, MS |
| 14 | Sat Jan 6 | at South Carolina | L62-68 | 11-3 | .786 | - | CBS | Colonial Life Arena · Columbia, SC |
| 15 | Wed Jan 10 | vs #5Tennessee | W77-72 | 12-3 | .800 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 16 | Sat Jan 13 | vs Alabama | L74-82 | 12-4 | .750 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Wed Jan 17 | at #8Kentucky | L77-90 | 12-5 | .706 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 18 | Sat Jan 20 | vs Vanderbilt | W68-55 | 13-5 | .722 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 19 | Wed Jan 24 | at Florida | L70-79 | 13-6 | .684 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 20 | Sat Jan 27 | vs #8Auburn | W64-58 | 14-6 | .700 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 21 | Tue Jan 30 | at Ole Miss | L82-86 | 14-7 | .667 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 22 | Sat Feb 3 | at#24Alabama | L67-99 | 14-8 | .636 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 23 | Wed Feb 7 | vs Georgia | W75-62 | 15-8 | .652 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 24 | Sat Feb 10 | at Missouri | W75-51 | 16-8 | .667 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 25 | Sat Feb 17 | vs Arkansas | W71-67 | 17-8 | .680 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 26 | Wed Feb 21 | vsOle Miss | W83-71 | 18-8 | .692 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 24 | at LSU | W87-67 | 19-8 | .704 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 28 | Tue Feb 27 | vs#16Kentucky | L89-91 | 19-9 | .679 | - | ESPN | Humphrey Coliseum · Starkville, MS |
| 29 | Sat Mar 2 | at#11Auburn | L63-78 | 19-10 | .655 | - | ESPN2 | Neville Arena · Auburn, AL |
| 30 | Wed Mar 6 | at Texas A&M | L69-75 | 19-11 | .633 | - | ESPNU | Reed Arena · College Station, TX |
| 31 | Sat Mar 9 | vs#17South Carolina | L89-93 (OT) | 19-12 | .613 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 32 | Thu Mar 14 | atLSU | W70-60 | 20-12 | .625 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 33 | Fri Mar 15 | at#5Tennessee | W73-56 | 21-12 | .636 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 34 | Sat Mar 16 | at#12Auburn | L66-73 | 21-13 | .618 | - | ESPN | Neville Arena · Auburn, AL |
| 35 | Thu Mar 21 | vs #9Michigan St | L51-69 | 21-14 | .600 | #8 | CBS | Humphrey Coliseum · Starkville, MS |
