| 1 | Wed Nov 10 | vs North Alabama | W75-49 | 1-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 2 | Sat Nov 13 | vs Montana | W86-49 | 2-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 3 | Wed Nov 17 | vs Detroit Mercy | W77-64 | 3-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 4 | Sun Nov 21 | vs Morehead St | W66-46 | 4-0 | 1.000 | - | | Humphrey Coliseum · Starkville, MS |
| 5 | Thu Nov 25 | at Louisville | L58-72 | 4-1 | .800 | - | CBS | KFC Yum! Center · Louisville, KY |
| 6 | Sat Nov 27 | at Richmond | W82-71 (OT) | 5-1 | .833 | - | | Robins Center · Richmond, VA |
| 7 | Thu Dec 2 | vs Lamar | W75-60 | 6-1 | .857 | - | | Humphrey Coliseum · Starkville, MS |
| 8 | Sun Dec 5 | vs Minnesota | L76-81 | 6-2 | .750 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 9 | Sat Dec 11 | at Colorado St | L63-66 | 6-3 | .667 | - | ESPNU | Moby Arena · Fort Collins, CO |
| 10 | Tue Dec 14 | vs Georgia St | W79-50 | 7-3 | .700 | - | | Humphrey Coliseum · Starkville, MS |
| 11 | Fri Dec 17 | vs Furman | W69-66 | 8-3 | .727 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 12 | Tue Dec 21 | vs Winthrop | W84-63 | 9-3 | .750 | - | | Humphrey Coliseum · Starkville, MS |
| 13 | Wed Dec 29 | vs Arkansas | W81-68 | 10-3 | .769 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 14 | Wed Jan 5 | at Missouri | PPD | 18-16 | .529 | - | | Mizzou Arena · Columbia, MO |
| 15 | Sat Jan 8 | at Ole Miss | L72-82 | 10-4 | .714 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 16 | Wed Jan 12 | vs Georgia | W88-72 | 11-4 | .733 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Sat Jan 15 | vs #24Alabama | W78-76 | 12-4 | .750 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 18 | Wed Jan 19 | at Florida | L72-80 | 12-5 | .706 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 19 | Sat Jan 22 | vsOle Miss | W78-60 | 13-5 | .722 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 20 | Tue Jan 25 | at #12Kentucky | L74-82 (OT) | 13-6 | .684 | - | ESPN | Rupp Arena · Lexington, KY |
| 21 | Sat Jan 29 | at Texas Tech | L50-76 | 13-7 | .650 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 22 | Tue Feb 1 | vs South Carolina | W78-64 | 14-7 | .667 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 23 | Sat Feb 5 | atArkansas | L55-63 | 14-8 | .636 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 24 | Wed Feb 9 | vs #19Tennessee | L63-72 | 14-9 | .609 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 25 | Sat Feb 12 | at LSU | L65-69 | 14-10 | .583 | - | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 26 | Wed Feb 16 | at#25Alabama | L75-80 | 14-11 | .560 | - | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 27 | Fri Feb 18 | vsMissouri | W68-49 | 15-11 | .577 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 28 | Sun Feb 20 | atMissouri | W58-56 | 16-11 | .593 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 29 | Wed Feb 23 | atSouth Carolina | L56-66 | 16-12 | .571 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 30 | Sat Feb 26 | vs Vanderbilt | W74-69 | 17-12 | .586 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 31 | Wed Mar 2 | vs #5Auburn | L68-81 (OT) | 17-13 | .567 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 32 | Sat Mar 5 | at Texas A&M | L64-67 | 17-14 | .548 | - | SEC Network | Reed Arena · College Station, TX |
| 33 | Thu Mar 10 | atSouth Carolina | W73-51 | 18-14 | .563 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 34 | Fri Mar 11 | atTennessee | L59-72 | 18-15 | .545 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 35 | Wed Mar 16 | at Virginia | L57-60 | 18-16 | .529 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
