| 1 | Mon Nov 6 | at #24Alabama | L73-105 | 0-1 | .000 | - | | Coleman Coliseum · Tuscaloosa, AL |
| 2 | Wed Nov 8 | vs TBD | W96-40 | 1-1 | .500 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 3 | Fri Nov 10 | at #3Purdue | L57-87 | 1-2 | .333 | - | | Mackey Arena · West Lafayette, IN |
| 4 | Tue Nov 14 | vs Mercer | W74-66 | 2-2 | .500 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 5 | Fri Nov 17 | at Penn State | L51-74 | 2-3 | .400 | - | | Bryce Jordan Center · University Park, PA |
| 6 | Mon Nov 20 | at Bellarmine | W64-51 | 3-3 | .500 | - | | Knights Hall · Louisville, KY |
| 7 | Wed Nov 22 | vsTBD | W94-53 | 4-3 | .571 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 8 | Wed Nov 29 | at Austin Peay | W61-50 | 5-3 | .625 | - | | Winfield Dunn Center · Clarksville, TN |
| 9 | Sun Dec 3 | vs Chattanooga | W87-80 | 6-3 | .667 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 10 | Sun Dec 10 | at North Alabama | W86-77 | 7-3 | .700 | - | | Flowers Hall · Florence, AL |
| 11 | Thu Dec 14 | vsTBD | W102-33 | 8-3 | .727 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 12 | Tue Dec 19 | at Indiana | L68-69 | 8-4 | .667 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 13 | Thu Dec 21 | vsTBD | W101-39 | 9-4 | .692 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 14 | Sun Dec 31 | at SE Missouri St | W83-64 | 10-4 | .714 | - | | Show Me Center · Cape Girardeau, MO |
| 15 | Thu Jan 4 | vs Tennessee Tech | W82-57 | 11-4 | .733 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 16 | Sat Jan 6 | vs Tennessee St | W78-68 | 12-4 | .750 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Thu Jan 11 | at E Illinois | W78-52 | 13-4 | .765 | - | | Lantz Arena · Charleston, IL |
| 18 | Sat Jan 13 | at SIUE | L48-61 | 13-5 | .722 | - | ESPNU | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 19 | Thu Jan 18 | vs UT Martin | W84-66 | 14-5 | .737 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 20 | Sat Jan 20 | at So Indiana | W81-70 | 15-5 | .750 | - | | Screaming Eagles Arena · Evansville, IN |
| 21 | Sat Jan 27 | vs W Illinois | W64-50 | 16-5 | .762 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 22 | Thu Feb 1 | atTennessee St | W68-49 | 17-5 | .773 | - | | Gentry Center · Nashville, TN |
| 23 | Sat Feb 3 | atTennessee Tech | W67-60 | 18-5 | .783 | - | | Hooper Eblen Center · Cookeville, TN |
| 24 | Thu Feb 8 | vsSIUE | W79-68 | 19-5 | .792 | - | ESPNU | Ellis T. Johnson Arena · Morehead, KY |
| 25 | Sat Feb 10 | vsE Illinois | W69-57 | 20-5 | .800 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 26 | Thu Feb 15 | at Little Rock | L68-69 | 20-6 | .769 | - | | Jack Stephens Center · Little Rock, AR |
| 27 | Sat Feb 17 | atUT Martin | L82-88 | 20-7 | .741 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 28 | Tue Feb 20 | vsSo Indiana | L73-80 | 20-8 | .714 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 29 | Thu Feb 22 | atW Illinois | W78-57 | 21-8 | .724 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 30 | Thu Feb 29 | vsSE Missouri St | W72-50 | 22-8 | .733 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 31 | Sat Mar 2 | vs Lindenwood | W67-49 | 23-8 | .742 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 32 | Thu Mar 7 | vsSIUE | W78-63 | 24-8 | .750 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 33 | Fri Mar 8 | atUT Martin | W84-78 | 25-8 | .758 | - | ESPNU | Kathleen and Tom Elam Center · Martin, TN |
| 34 | Sat Mar 9 | atLittle Rock | W69-55 | 26-8 | .765 | - | ESPN2 | Jack Stephens Center · Little Rock, AR |
| 35 | Thu Mar 21 | at #3Illinois | L69-85 | 26-9 | .743 | #14 | truTV | State Farm Center · Champaign, IL |
