| 1 | Wed Nov 25 | at Kentucky | L45-81 | 0-1 | .000 | - | SEC Network | Rupp Arena · Lexington, KY |
| 2 | Fri Nov 27 | at Richmond | L64-82 | 0-2 | .000 | - | | Robins Center · Richmond, VA |
| 3 | Sun Nov 29 | vs Arkansas St | W69-61 | 1-2 | .333 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 4 | Wed Dec 2 | at #23Ohio State | L44-77 | 1-3 | .250 | - | BTN | Value City Arena · Columbus, OH |
| 5 | Mon Dec 7 | at E Kentucky | L68-71 | 1-4 | .200 | - | | McBrayer Arena · Richmond, KY |
| 6 | Wed Dec 9 | vs TBD | W77-55 | 2-4 | .333 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 7 | Thu Dec 10 | vsTBD | W81-55 | 3-4 | .429 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 8 | Mon Dec 14 | vsE Kentucky | W75-62 | 4-4 | .500 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 9 | Fri Dec 18 | vs SIUE | L65-69 | 4-5 | .444 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 10 | Mon Dec 21 | at Clemson | L51-66 | 4-6 | .400 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 11 | Sat Jan 2 | at Murray St | W61-56 | 5-6 | .455 | - | | CFSB Center · Murray, KY |
| 12 | Thu Jan 7 | vs Tennessee Tech | W57-54 | 6-6 | .500 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 13 | Sat Jan 9 | vs J'Ville St | W56-55 | 7-6 | .538 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 14 | Thu Jan 14 | at E Illinois | W87-61 | 8-6 | .571 | - | ESPNU | Lantz Arena · Charleston, IL |
| 15 | Sat Jan 16 | at SE Missouri St | W64-50 | 9-6 | .600 | - | | Show Me Center · Cape Girardeau, MO |
| 16 | Thu Jan 21 | vsSE Missouri St | W76-65 | 10-6 | .625 | - | ESPNU | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Sat Jan 23 | vs UT Martin | W76-44 | 11-6 | .647 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 18 | Thu Jan 28 | atJ'Ville St | W85-66 | 12-6 | .667 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 19 | Sat Jan 30 | atTennessee Tech | W74-55 | 13-6 | .684 | - | | Hooper Eblen Center · Cookeville, TN |
| 20 | Thu Feb 4 | vsMurray St | W66-56 | 14-6 | .700 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 21 | Sat Feb 6 | vs Austin Peay | W75-74 (OT) | 15-6 | .714 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 22 | Thu Feb 11 | at Tennessee St | W79-66 | 16-6 | .727 | - | | Gentry Center · Nashville, TN |
| 23 | Sat Feb 13 | at Belmont | L58-73 | 16-7 | .696 | - | | Curb Event Center Arena · Nashville, TN |
| 25 | Sat Feb 20 | atUT Martin | W79-69 | 17-7 | .708 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 26 | Mon Feb 22 | atSIUE | W56-48 | 18-7 | .720 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 27 | Thu Feb 25 | vsTennessee St | W74-60 | 19-7 | .731 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 28 | Sat Feb 27 | vsBelmont | W89-82 (OT) | 20-7 | .741 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 29 | Wed Mar 3 | vsSE Missouri St | W61-54 | 21-7 | .750 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 30 | Fri Mar 5 | vsE Kentucky | W67-64 | 22-7 | .759 | - | ESPNU | Ellis T. Johnson Arena · Morehead, KY |
| 31 | Sat Mar 6 | atBelmont | W86-71 | 23-7 | .767 | - | ESPN2 | Curb Event Center Arena · Nashville, TN |
| 32 | Fri Mar 19 | at #3West Virginia | L67-84 | 23-8 | .742 | #14 | truTV | WVU Coliseum · Morgantown, WV |
