| 1 | Mon Nov 3 | at Virginia Tech | 7:00 PM | 13-19 | .406 | - | | Cassell Coliseum · Blacksburg, VA |
| 2 | Thu Nov 6 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 3 | Mon Nov 10 | atThe Citadel | 7:00 PM | 5-25 | .167 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 4 | Thu Nov 13 | atAlabama A&M | 8:00 PM | 10-22 | .313 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 5 | Fri Nov 14 | vsLindenwood | 6:30 PM | 16-17 | .485 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 6 | Tue Nov 18 | vsIU Indy | 7:00 PM | 10-22 | .313 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 7 | Fri Nov 21 | atE Carolina | 7:00 PM | 19-14 | .576 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 8 | Tue Nov 25 | vsTBD | 7:30 PM | 0-0 | .000 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 9 | Fri Nov 28 | atSouth Carolina | 4:00 PM | 12-20 | .375 | - | | Colonial Life Arena · Columbia, SC |
| 10 | Tue Dec 2 | atUT Martin | 12:00 PM | 14-19 | .424 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 11 | Thu Dec 4 | vsTBD | 7:00 PM | 0-0 | .000 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 12 | Mon Dec 8 | vsSC State | 7:00 PM | 20-13 | .606 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 13 | Thu Dec 18 | vsNorth Florida | 11:00 AM | 15-17 | .469 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 14 | Sun Dec 21 | atFurman | TBD | 25-10 | .714 | - | | Timmons Arena · Greenville, SC |
| 15 | Sun Dec 28 | atRichmond | TBD | 10-22 | .313 | - | | Robins Center · Richmond, VA |
| 16 | Wed Dec 31 | atGardner-Webb | 7:00 PM | 11-20 | .355 | - | | Paul Porter Arena · Boiling Springs, NC |
| 17 | Sat Jan 3 | vsUNC Asheville | 2:00 PM | 21-11 | .656 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 18 | Wed Jan 7 | atWinthrop | TBD | 23-11 | .676 | - | | Winthrop Coliseum · Rock Hill, SC |
| 19 | Sat Jan 10 | vsHigh Point | 2:00 PM | 29-6 | .829 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 20 | Wed Jan 14 | vsSC Upstate | 7:00 PM | 6-26 | .188 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 21 | Wed Jan 21 | atPresbyterian | TBD | 14-19 | .424 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Sat Jan 24 | atLongwood | TBD | 18-14 | .563 | - | | Willett Hall · Farmville, VA |
| 23 | Thu Jan 29 | vsRadford | 7:00 PM | 20-13 | .606 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 24 | Sat Jan 31 | vsGardner-Webb | 2:00 PM | 11-20 | .355 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 25 | Wed Feb 4 | atHigh Point | 7:00 PM | 29-6 | .829 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 26 | Sat Feb 7 | atSC Upstate | 2:00 PM | 6-26 | .188 | - | | G.B. Hodge Center · Spartanburg, SC |
| 27 | Thu Feb 12 | vsPresbyterian | 7:00 PM | 14-19 | .424 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 28 | Sat Feb 14 | atRadford | TBD | 20-13 | .606 | - | | Donald N. Dedmon Center · Radford, VA |
| 29 | Sat Feb 21 | vsLongwood | 4:00 PM | 18-14 | .563 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 30 | Thu Feb 26 | vsWinthrop | 7:00 PM | 23-11 | .676 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 31 | Sat Feb 28 | atUNC Asheville | TBD | 21-11 | .656 | - | | Kimmel Arena · Asheville, NC |
