| 1 | Mon Nov 6 | vs TBD | W94-59 | 1-0 | 1.000 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 2 | Thu Nov 9 | vs North Florida | L70-81 | 1-1 | .500 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 3 | Mon Nov 13 | vsTBD | W102-61 | 2-1 | .667 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 4 | Fri Nov 17 | at NC State | L53-87 | 2-2 | .500 | - | | PNC Arena · Raleigh, NC |
| 5 | Mon Nov 20 | at Bethune | L73-79 | 2-3 | .400 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 6 | Fri Nov 24 | at Wake Forest | L56-71 | 2-4 | .333 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 7 | Tue Nov 28 | at The Citadel | L52-81 | 2-5 | .286 | - | | McAlister Field House · Charleston, SC |
| 8 | Sat Dec 2 | vs SC State | W66-64 | 3-5 | .375 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 9 | Wed Dec 13 | vs North Alabama | L64-76 | 3-6 | .333 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 10 | Sat Dec 16 | at South Carolina | L69-73 | 3-7 | .300 | - | | Colonial Life Arena · Columbia, SC |
| 11 | Tue Dec 19 | at Loyola Chicago | L59-72 | 3-8 | .273 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 12 | Thu Dec 21 | vsTBD | W103-79 | 4-8 | .333 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 13 | Fri Dec 29 | at #9UNC | L60-105 | 4-9 | .308 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 14 | Wed Jan 3 | vs Presbyterian | L61-68 | 4-10 | .286 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 15 | Sat Jan 6 | at Longwood | L56-77 | 4-11 | .267 | - | | Willett Hall · Farmville, VA |
| 16 | Wed Jan 10 | at Gardner-Webb | W86-74 | 5-11 | .313 | - | | Paul Porter Arena · Boiling Springs, NC |
| 17 | Sat Jan 13 | vs SC Upstate | W77-70 | 6-11 | .353 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 18 | Sat Jan 20 | at High Point | L79-86 | 6-12 | .333 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 19 | Wed Jan 24 | vs Winthrop | L59-78 | 6-13 | .316 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 20 | Sat Jan 27 | vs UNC Asheville | L65-71 | 6-14 | .300 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 21 | Wed Jan 31 | at Radford | W63-60 | 7-14 | .333 | - | | Donald N. Dedmon Center · Radford, VA |
| 22 | Sat Feb 3 | vsLongwood | W83-77 | 8-14 | .364 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 23 | Wed Feb 7 | atWinthrop | L46-67 | 8-15 | .348 | - | | Winthrop Coliseum · Rock Hill, SC |
| 24 | Wed Feb 14 | vsGardner-Webb | L77-85 | 8-16 | .333 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 25 | Sat Feb 17 | atUNC Asheville | L55-86 | 8-17 | .320 | - | | Kimmel Arena · Asheville, NC |
| 26 | Wed Feb 21 | atSC Upstate | W63-60 | 9-17 | .346 | - | | G.B. Hodge Center · Spartanburg, SC |
| 27 | Sat Feb 24 | vsHigh Point | L59-74 | 9-18 | .333 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 28 | Wed Feb 28 | vsRadford | W58-57 | 10-18 | .357 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 29 | Sat Mar 2 | atPresbyterian | L65-72 | 10-19 | .345 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 30 | Fri Mar 8 | atUNC Asheville | L55-60 | 10-20 | .333 | - | | Kimmel Arena · Asheville, NC |
