| 1 | Mon Nov 7 | vs TBD | W83-52 | 1-0 | 1.000 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 2 | Thu Nov 10 | at Ohio State | L56-82 | 1-1 | .500 | - | BTN | Value City Arena · Columbus, OH |
| 3 | Wed Nov 16 | at Tulane | L79-99 | 1-2 | .333 | - | | Devlin Fieldhouse · New Orleans, LA |
| 4 | Mon Nov 21 | vs Bethune | W78-63 | 2-2 | .500 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 5 | Fri Nov 25 | at Virginia Tech | L64-69 | 2-3 | .400 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 6 | Wed Nov 30 | vs The Citadel | L73-76 | 2-4 | .333 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 7 | Fri Dec 2 | at South Florida | L59-79 | 2-5 | .286 | - | | Yuengling Center · Tampa, FL |
| 8 | Mon Dec 5 | vs Kennesaw St | L65-76 | 2-6 | .250 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 9 | Wed Dec 14 | at Tennessee St | W91-87 | 3-6 | .333 | - | | Gentry Center · Nashville, TN |
| 10 | Sat Dec 17 | at Jacksonville | L63-72 | 3-7 | .300 | - | | Swisher Gymnasium · Jacksonville, FL |
| 11 | Thu Dec 22 | vsTBD | W126-67 | 4-7 | .364 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 12 | Thu Dec 29 | at Gardner-Webb | L63-83 | 4-8 | .333 | - | | Paul Porter Arena · Boiling Springs, NC |
| 13 | Sat Dec 31 | vs SC Upstate | W90-85 | 5-8 | .385 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 14 | Wed Jan 4 | vs Longwood | L74-79 | 5-9 | .357 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 15 | Sat Jan 7 | at Presbyterian | W67-61 | 6-9 | .400 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 16 | Wed Jan 11 | vs High Point | W106-69 | 7-9 | .438 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 17 | Sat Jan 14 | at Radford | L70-75 | 7-10 | .412 | - | | Donald N. Dedmon Center · Radford, VA |
| 18 | Wed Jan 18 | vs UNC Asheville | L63-73 | 7-11 | .389 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 19 | Sat Jan 21 | vs Campbell | L76-78 (OT) | 7-12 | .368 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 20 | Wed Jan 25 | at Winthrop | L64-76 | 7-13 | .350 | - | | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 28 | atLongwood | W75-63 | 8-13 | .381 | - | | Willett Hall · Farmville, VA |
| 22 | Wed Feb 1 | vsGardner-Webb | L59-67 | 8-14 | .364 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 23 | Sat Feb 4 | atHigh Point | L73-81 | 8-15 | .348 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 24 | Wed Feb 8 | atSC Upstate | L60-77 | 8-16 | .333 | - | | G.B. Hodge Center · Spartanburg, SC |
| 25 | Sat Feb 11 | vsRadford | L71-90 | 8-17 | .320 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 26 | Wed Feb 15 | atCampbell | L51-67 | 8-18 | .308 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 27 | Sat Feb 18 | vsWinthrop | L67-75 | 8-19 | .296 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 28 | Wed Feb 22 | atUNC Asheville | L62-80 | 8-20 | .286 | - | | Kimmel Arena · Asheville, NC |
| 29 | Sat Feb 25 | vsPresbyterian | W85-59 | 9-20 | .310 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 30 | Wed Mar 1 | atHigh Point | W72-70 | 10-20 | .333 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 31 | Fri Mar 3 | atUNC Asheville | L66-75 | 10-21 | .323 | - | | Kimmel Arena · Asheville, NC |
