| 1 | Mon Nov 6 | at NC State | L59-72 | 0-1 | .000 | - | | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 10 | vs Boston College | L71-75 | 0-2 | .000 | - | | McAlister Field House · Charleston, SC |
| 3 | Mon Nov 13 | at Presbyterian | L64-71 | 0-3 | .000 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Thu Nov 16 | vs TBD | W77-59 | 1-3 | .250 | - | | McAlister Field House · Charleston, SC |
| 5 | Mon Nov 20 | at Idaho St | W62-61 | 2-3 | .400 | - | | Reed Gym · Pocatello, ID |
| 6 | Tue Nov 21 | vs NC Central | W67-61 | 3-3 | .500 | - | | McAlister Field House · Charleston, SC |
| 7 | Wed Nov 22 | at Campbell | L58-65 | 3-4 | .429 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 8 | Tue Nov 28 | vs Charleston So | W81-52 | 4-4 | .500 | - | | McAlister Field House · Charleston, SC |
| 9 | Sat Dec 2 | at NC A&T | W85-68 | 5-4 | .556 | - | | Corbett Sports Center · Greensboro, NC |
| 10 | Tue Dec 5 | vsTBD | W88-60 | 6-4 | .600 | - | | McAlister Field House · Charleston, SC |
| 11 | Thu Dec 14 | at Charleston | L71-86 | 6-5 | .545 | - | | TD Arena · Charleston, SC |
| 12 | Tue Dec 19 | at Notre Dame | W65-45 | 7-5 | .583 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 13 | Sat Dec 30 | vsTBD | W106-76 | 8-5 | .615 | - | | McAlister Field House · Charleston, SC |
| 14 | Wed Jan 3 | vs W Carolina | L71-80 | 8-6 | .571 | - | | McAlister Field House · Charleston, SC |
| 15 | Sat Jan 6 | vs Samford | L64-80 | 8-7 | .533 | - | | McAlister Field House · Charleston, SC |
| 16 | Wed Jan 10 | at Furman | L68-82 | 8-8 | .500 | - | | Timmons Arena · Greenville, SC |
| 17 | Sat Jan 13 | vs Wofford | L71-72 | 8-9 | .471 | - | | McAlister Field House · Charleston, SC |
| 18 | Wed Jan 17 | at UNC Greensboro | L67-73 | 8-10 | .444 | - | | Greensboro Coliseum · Greensboro, NC |
| 19 | Sat Jan 20 | at VMI | L63-70 | 8-11 | .421 | - | | Cameron Hall · Lexington, VA |
| 20 | Wed Jan 24 | vs Mercer | W68-66 | 9-11 | .450 | - | | McAlister Field House · Charleston, SC |
| 21 | Sat Jan 27 | at Chattanooga | L62-90 | 9-12 | .429 | - | | McKenzie Arena · Chattanooga, TN |
| 22 | Wed Jan 31 | vsFurman | L79-82 (OT) | 9-13 | .409 | - | | McAlister Field House · Charleston, SC |
| 23 | Sat Feb 3 | at ETSU | L60-62 | 9-14 | .391 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 24 | Wed Feb 7 | atW Carolina | L64-71 | 9-15 | .375 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 25 | Sat Feb 10 | atWofford | L64-77 | 9-16 | .360 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 26 | Wed Feb 14 | vsUNC Greensboro | L61-76 | 9-17 | .346 | - | | McAlister Field House · Charleston, SC |
| 27 | Sat Feb 17 | vsVMI | W76-51 | 10-17 | .370 | - | | McAlister Field House · Charleston, SC |
| 28 | Wed Feb 21 | atMercer | L78-87 | 10-18 | .357 | - | | Hawkins Arena · Macon, GA |
| 29 | Sat Feb 24 | vsChattanooga | W71-62 | 11-18 | .379 | - | | McAlister Field House · Charleston, SC |
| 30 | Wed Feb 28 | vsETSU | L63-81 | 11-19 | .367 | - | | McAlister Field House · Charleston, SC |
| 31 | Sat Mar 2 | atSamford | L80-92 | 11-20 | .355 | - | | Pete Hanna Center · Homewood, AL |
| 32 | Fri Mar 8 | atMercer | L76-84 | 11-21 | .344 | - | | Hawkins Arena · Macon, GA |
