| 1 | Sat Nov 9 | vs UNC Asheville | L76-91 | 0-1 | .000 | - | | McAlister Field House · Charleston, SC |
| 2 | Tue Nov 12 | atGeorgia | L86-95 | 0-2 | .000 | - | | Stegeman Coliseum · Athens, GA |
| 3 | Sat Nov 16 | vsCampbell | L73-87 | 0-3 | .000 | - | | McAlister Field House · Charleston, SC |
| 4 | Tue Nov 19 | atSE Missouri St | W74-69 | 1-3 | .250 | - | | Show Me Center · Cape Girardeau, MO |
| 5 | Wed Nov 20 | atIllinois | L57-85 | 1-4 | .200 | - | BTN | State Farm Center · Champaign, IL |
| 6 | Sat Nov 23 | atMarist | W79-75 | 2-4 | .333 | - | | McCann Arena · Poughkeepsie, NY |
| 7 | Tue Nov 26 | vsTBD | W90-47 | 3-4 | .429 | - | | McAlister Field House · Charleston, SC |
| 8 | Wed Dec 4 | vsETSU | L84-96 | 3-5 | .375 | - | | McAlister Field House · Charleston, SC |
| 9 | Sat Dec 7 | vsTBD | W108-40 | 4-5 | .444 | - | | McAlister Field House · Charleston, SC |
| 10 | Tue Dec 10 | vsTBD | W129-83 | 5-5 | .500 | - | | McAlister Field House · Charleston, SC |
| 11 | Thu Dec 19 | atLongwood | W102-99 (3OT) | 6-5 | .545 | - | | Willett Hall · Farmville, VA |
| 12 | Sun Dec 22 | atNC State | L63-83 | 6-6 | .500 | - | ACC Network | PNC Arena · Raleigh, NC |
| 13 | Wed Jan 1 | atSamford | L68-69 | 6-7 | .462 | - | | Pete Hanna Center · Homewood, AL |
| 14 | Sat Jan 4 | vsW Carolina | L82-86 | 6-8 | .429 | - | | McAlister Field House · Charleston, SC |
| 15 | Sat Jan 11 | atWofford | L71-73 | 6-9 | .400 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 16 | Wed Jan 15 | vsUNC Greensboro | L69-79 | 6-10 | .375 | - | | McAlister Field House · Charleston, SC |
| 17 | Sat Jan 18 | atVMI | L79-88 | 6-11 | .353 | - | | Cameron Hall · Lexington, VA |
| 18 | Wed Jan 22 | atChattanooga | L69-92 | 6-12 | .333 | - | | McKenzie Arena · Chattanooga, TN |
| 19 | Sat Jan 25 | vsFurman | L54-78 | 6-13 | .316 | - | | McAlister Field House · Charleston, SC |
| 20 | Wed Jan 29 | vsWofford | L56-79 | 6-14 | .300 | - | | McAlister Field House · Charleston, SC |
| 21 | Sat Feb 1 | atMercer | L71-76 | 6-15 | .286 | - | | Hawkins Arena · Macon, GA |
| 22 | Wed Feb 5 | atUNC Greensboro | L68-88 | 6-16 | .273 | - | | Greensboro Coliseum · Greensboro, NC |
| 23 | Sat Feb 8 | vsVMI | L64-75 | 6-17 | .261 | - | | McAlister Field House · Charleston, SC |
| 24 | Wed Feb 12 | atETSU | L67-91 | 6-18 | .250 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 25 | Sat Feb 15 | vsSamford | L62-74 | 6-19 | .240 | - | | McAlister Field House · Charleston, SC |
| 26 | Wed Feb 19 | vsChattanooga | L68-91 | 6-20 | .231 | - | | McAlister Field House · Charleston, SC |
| 27 | Sat Feb 22 | atW Carolina | L84-96 | 6-21 | .222 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 28 | Wed Feb 26 | vsMercer | L57-73 | 6-22 | .214 | - | | McAlister Field House · Charleston, SC |
| 29 | Sat Feb 29 | atFurman | L58-82 | 6-23 | .207 | - | | Timmons Arena · Greenville, SC |
| 30 | Fri Mar 6 | atWofford | L76-93 | 6-24 | .200 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
