| 1 | Tue Nov 9 | at Pitt | W78-63 | 1-0 | 1.000 | - | | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 12 | vsTBD | W108-67 | 2-0 | 1.000 | - | | McAlister Field House · Charleston, SC |
| 3 | Mon Nov 15 | atPresbyterian | L70-74 (2OT) | 2-1 | .667 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Thu Nov 18 | vsTBD | W102-49 | 3-1 | .750 | - | | McAlister Field House · Charleston, SC |
| 5 | Mon Nov 22 | at#5Duke | L81-107 | 3-2 | .600 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 6 | Sun Nov 28 | atSC State | W91-79 (OT) | 4-2 | .667 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 7 | Wed Dec 1 | atUNC Asheville | L58-65 | 4-3 | .571 | - | | Kimmel Arena · Asheville, NC |
| 8 | Mon Dec 6 | vsNC Central | W80-67 | 5-3 | .625 | - | | McAlister Field House · Charleston, SC |
| 9 | Thu Dec 16 | vsTBD | W102-62 | 6-3 | .667 | - | | McAlister Field House · Charleston, SC |
| 10 | Mon Dec 20 | vsSC State | L57-74 | 6-4 | .600 | - | | McAlister Field House · Charleston, SC |
| 11 | Tue Dec 21 | vsManhattan | L74-77 | 6-5 | .545 | - | | McAlister Field House · Charleston, SC |
| 12 | Wed Dec 29 | vsMercer | PPD | 13-18 | .419 | - | | McAlister Field House · Charleston, SC |
| 13 | Sat Jan 1 | atSamford | PPD | 13-18 | .419 | - | | Pete Hanna Center · Homewood, AL |
| 14 | Wed Jan 5 | atW Carolina | L90-94 (OT) | 6-6 | .500 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 15 | Sat Jan 8 | atChattanooga | L67-85 | 6-7 | .462 | - | | McKenzie Arena · Chattanooga, TN |
| 16 | Thu Jan 13 | vsUNC Greensboro | W74-69 | 7-7 | .500 | - | | McAlister Field House · Charleston, SC |
| 17 | Sat Jan 15 | vsVMI | L85-90 | 7-8 | .467 | - | | McAlister Field House · Charleston, SC |
| 18 | Mon Jan 17 | vsMercer | L64-71 | 7-9 | .438 | - | | McAlister Field House · Charleston, SC |
| 19 | Wed Jan 19 | atWofford | L77-89 | 7-10 | .412 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 20 | Sat Jan 22 | atETSU | W75-73 | 8-10 | .444 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 21 | Wed Jan 26 | vsW Carolina | W68-66 | 9-10 | .474 | - | | McAlister Field House · Charleston, SC |
| 22 | Sat Jan 29 | vsChattanooga | L62-75 | 9-11 | .450 | - | | McAlister Field House · Charleston, SC |
| 23 | Wed Feb 2 | atFurman | L83-102 | 9-12 | .429 | - | | Timmons Arena · Greenville, SC |
| 24 | Sat Feb 5 | vsSamford | W107-93 | 10-12 | .455 | - | | McAlister Field House · Charleston, SC |
| 25 | Thu Feb 10 | atUNC Greensboro | L66-86 | 10-13 | .435 | - | | Greensboro Coliseum · Greensboro, NC |
| 26 | Sat Feb 12 | atVMI | W83-79 | 11-13 | .458 | - | CBS | Cameron Hall · Lexington, VA |
| 27 | Wed Feb 16 | vsWofford | L58-65 | 11-14 | .440 | - | | McAlister Field House · Charleston, SC |
| 28 | Sat Feb 19 | vsETSU | L67-77 | 11-15 | .423 | - | | McAlister Field House · Charleston, SC |
| 29 | Mon Feb 21 | atSamford | L74-76 | 11-16 | .407 | - | | Pete Hanna Center · Homewood, AL |
| 30 | Wed Feb 23 | atMercer | W71-67 | 12-16 | .429 | - | | Hawkins Arena · Macon, GA |
| 31 | Sat Feb 26 | vsFurman | L59-94 | 12-17 | .414 | - | | McAlister Field House · Charleston, SC |
| 32 | Fri Mar 4 | atETSU | W84-76 (OT) | 13-17 | .433 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 33 | Sat Mar 5 | atChattanooga | L66-71 | 13-18 | .419 | - | | McKenzie Arena · Chattanooga, TN |
