| 1 | Tue Nov 9 | vs Bradley | W81-65 | 1-0 | 1.000 | - | | Frost Arena · Brookings, SD |
| 2 | Fri Nov 12 | at #14Alabama | L88-104 | 1-1 | .500 | - | | Coleman Coliseum · Tuscaloosa, AL |
| 3 | Sun Nov 14 | at SF Austin | W83-71 | 2-1 | .667 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 4 | Wed Nov 17 | vs Montana St | W91-74 | 3-1 | .750 | - | | Frost Arena · Brookings, SD |
| 5 | Thu Nov 18 | vs TBD | W99-62 | 4-1 | .800 | - | | Frost Arena · Brookings, SD |
| 6 | Mon Nov 22 | at Nevada | W102-75 | 5-1 | .833 | - | | Lawlor Events Center · Reno, NV |
| 7 | Tue Nov 23 | vs Washington | L76-87 | 5-2 | .714 | - | | Frost Arena · Brookings, SD |
| 8 | Wed Nov 24 | vs George Mason | W80-76 | 6-2 | .750 | - | | Frost Arena · Brookings, SD |
| 9 | Tue Nov 30 | vs Prairie View | W99-90 | 7-2 | .778 | - | | Frost Arena · Brookings, SD |
| 10 | Fri Dec 3 | vsTBD | W112-47 | 8-2 | .800 | - | | Frost Arena · Brookings, SD |
| 11 | Wed Dec 8 | at Idaho | L84-98 | 8-3 | .727 | - | | ICCU Arena · Moscow, ID |
| 12 | Sat Dec 11 | at Washington St | W77-74 | 9-3 | .750 | - | | Friel Court at Beasley Coliseum · Pullman, WA |
| 13 | Wed Dec 15 | at Missouri St | L63-75 | 9-4 | .692 | - | | Great Southern Bank Arena · Springfield, MO |
| 14 | Mon Dec 20 | vs Kansas City | W89-57 | 10-4 | .714 | - | | Frost Arena · Brookings, SD |
| 15 | Wed Dec 22 | vs Oral Roberts | W82-76 | 11-4 | .733 | - | | Frost Arena · Brookings, SD |
| 16 | Thu Dec 30 | at N Dakota St | W90-86 | 12-4 | .750 | - | | Scheels Center · Fargo, ND |
| 17 | Sat Jan 1 | at North Dakota | PPD | 30-5 | .857 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 18 | Sat Jan 8 | vs South Dakota | W84-65 | 13-4 | .765 | - | | Frost Arena · Brookings, SD |
| 19 | Thu Jan 13 | at Omaha | W95-86 | 14-4 | .778 | - | | Baxter Arena · Omaha, NE |
| 20 | Sat Jan 15 | vs Denver | W80-62 | 15-4 | .789 | - | | Frost Arena · Brookings, SD |
| 21 | Thu Jan 20 | at St Thomas (MN) | W92-77 | 16-4 | .800 | - | | Schoenecker Arena · Saint Paul, MN |
| 22 | Sat Jan 22 | at W Illinois | W93-75 | 17-4 | .810 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 23 | Thu Jan 27 | vsNorth Dakota | W96-61 | 18-4 | .818 | - | | Frost Arena · Brookings, SD |
| 24 | Sat Jan 29 | vsN Dakota St | W80-76 | 19-4 | .826 | - | | Frost Arena · Brookings, SD |
| 25 | Mon Jan 31 | atNorth Dakota | W70-64 | 20-4 | .833 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 26 | Sat Feb 5 | atSouth Dakota | W89-79 | 21-4 | .840 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 27 | Thu Feb 10 | atDenver | W84-61 | 22-4 | .846 | - | | Hamilton Gymnasium · Denver, CO |
| 28 | Sat Feb 12 | vsOmaha | W82-61 | 23-4 | .852 | - | | Frost Arena · Brookings, SD |
| 29 | Thu Feb 17 | vsW Illinois | W91-66 | 24-4 | .857 | - | | Frost Arena · Brookings, SD |
| 30 | Sat Feb 19 | vsSt Thomas (MN) | W79-60 | 25-4 | .862 | - | | Frost Arena · Brookings, SD |
| 31 | Thu Feb 24 | atOral Roberts | W106-102 (OT) | 26-4 | .867 | - | | Mabee Center · Tulsa, OK |
| 32 | Sat Feb 26 | atKansas City | W86-75 | 27-4 | .871 | - | | Swinney Recreation Center · Kansas City, MO |
| 33 | Sat Mar 5 | vsOmaha | W87-79 | 28-4 | .875 | - | | Frost Arena · Brookings, SD |
| 34 | Mon Mar 7 | vsSouth Dakota | W83-60 | 29-4 | .879 | - | | Frost Arena · Brookings, SD |
| 35 | Tue Mar 8 | vsN Dakota St | W75-69 | 30-4 | .882 | - | ESPN2 | Frost Arena · Brookings, SD |
| 36 | Thu Mar 17 | at #4Providence | L57-66 | 30-5 | .857 | #13 | truTV | Amica Mutual Pavilion · Providence, RI |
