| 1 | Mon Nov 6 | vs Akron | L75-81 | 0-1 | .000 | - | | Frost Arena · Brookings, SD |
| 2 | Wed Nov 8 | vs TBD | W83-55 | 1-1 | .500 | - | | Frost Arena · Brookings, SD |
| 3 | Mon Nov 13 | at Kansas St | L68-91 | 1-2 | .333 | - | | Bramlage Coliseum · Manhattan, KS |
| 4 | Sun Nov 19 | vs UCF | L80-83 | 1-3 | .250 | - | | Frost Arena · Brookings, SD |
| 5 | Mon Nov 20 | at George Mason | L71-73 | 1-4 | .200 | - | | EagleBank Arena · Fairfax, VA |
| 6 | Wed Nov 22 | at Southern Miss | W65-54 | 2-4 | .333 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 7 | Mon Nov 27 | vsTBD | W92-70 | 3-4 | .429 | - | | Frost Arena · Brookings, SD |
| 8 | Fri Dec 1 | vs Towson | W61-48 | 4-4 | .500 | - | | Frost Arena · Brookings, SD |
| 9 | Tue Dec 5 | vs Kent State | L73-82 | 4-5 | .444 | - | | Frost Arena · Brookings, SD |
| 10 | Sat Dec 9 | at Wichita St | W79-69 | 5-5 | .500 | - | | Charles Koch Arena · Wichita, KS |
| 11 | Thu Dec 14 | vsTBD | W94-62 | 6-5 | .545 | - | | Frost Arena · Brookings, SD |
| 12 | Wed Dec 20 | vs Wyoming | L65-78 | 6-6 | .500 | - | | Frost Arena · Brookings, SD |
| 13 | Thu Dec 21 | at Norfolk St | L65-84 | 6-7 | .462 | - | | Joseph G. Echols Hall · Norfolk, VA |
| 14 | Sun Dec 31 | vs North Dakota | W80-61 | 7-7 | .500 | - | | Frost Arena · Brookings, SD |
| 15 | Wed Jan 3 | at Weber St | L73-75 | 7-8 | .467 | - | | Dee Events Center · Ogden, UT |
| 16 | Sat Jan 6 | vs Montana St | W89-61 | 8-8 | .500 | - | | Frost Arena · Brookings, SD |
| 17 | Thu Jan 11 | at St Thomas (MN) | W81-80 | 9-8 | .529 | - | | Schoenecker Arena · Saint Paul, MN |
| 18 | Sat Jan 13 | at Denver | L80-99 | 9-9 | .500 | - | | Hamilton Gymnasium · Denver, CO |
| 19 | Thu Jan 18 | vs Omaha | W90-87 | 10-9 | .526 | - | | Frost Arena · Brookings, SD |
| 20 | Sat Jan 20 | at South Dakota | W73-55 | 11-9 | .550 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 21 | Thu Jan 25 | vs Kansas City | W75-66 | 12-9 | .571 | - | CBS | Frost Arena · Brookings, SD |
| 22 | Sat Jan 27 | at Oral Roberts | L82-87 | 12-10 | .545 | - | | Mabee Center · Tulsa, OK |
| 23 | Thu Feb 1 | vs N Dakota St | L73-74 (OT) | 12-11 | .522 | - | | Frost Arena · Brookings, SD |
| 24 | Sun Feb 4 | vsSouth Dakota | W70-67 | 13-11 | .542 | - | CBS | Frost Arena · Brookings, SD |
| 25 | Sat Feb 10 | vsOral Roberts | W83-72 | 14-11 | .560 | - | | Frost Arena · Brookings, SD |
| 26 | Thu Feb 15 | atKansas City | L67-72 | 14-12 | .538 | - | | Swinney Recreation Center · Kansas City, MO |
| 27 | Sat Feb 17 | atOmaha | W85-77 (OT) | 15-12 | .556 | - | | Baxter Arena · Omaha, NE |
| 28 | Thu Feb 22 | vsDenver | W97-70 | 16-12 | .571 | - | | Frost Arena · Brookings, SD |
| 29 | Sat Feb 24 | vsSt Thomas (MN) | W77-72 | 17-12 | .586 | - | | Frost Arena · Brookings, SD |
| 30 | Thu Feb 29 | atNorth Dakota | W72-62 | 18-12 | .600 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 31 | Sat Mar 2 | atN Dakota St | W78-61 | 19-12 | .613 | - | | Scheels Center · Fargo, ND |
| 32 | Sat Mar 9 | vsOral Roberts | W79-63 | 20-12 | .625 | - | | Frost Arena · Brookings, SD |
| 33 | Mon Mar 11 | vsSt Thomas (MN) | W59-49 | 21-12 | .636 | - | | Frost Arena · Brookings, SD |
| 34 | Tue Mar 12 | vsDenver | W76-68 | 22-12 | .647 | - | CBS | Frost Arena · Brookings, SD |
| 35 | Thu Mar 21 | at #2Iowa State | L65-82 | 22-13 | .629 | #15 | truTV | James H. Hilton Coliseum · Ames, IA |
