| 1 | Wed Nov 25 | at Colorado | L61-84 | 0-1 | .000 | - | | CU Events Center · Boulder, CO |
| 2 | Fri Nov 27 | at Drake | L53-69 | 0-2 | .000 | - | | The Knapp Center · Des Moines, IA |
| 3 | Tue Dec 1 | at Nebraska | L69-76 | 0-3 | .000 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 5 | Thu Dec 10 | vs North Dakota | L71-75 | 0-4 | .000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Fri Dec 11 | at N Dakota St | L67-74 | 0-5 | .000 | - | | Scheels Center · Fargo, ND |
| 7 | Sat Dec 12 | at S Dakota St | W91-78 | 1-5 | .167 | - | | Frost Arena · Brookings, SD |
| 8 | Wed Dec 16 | vsDrake | PPD | 14-11 | .560 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 9 | Fri Dec 18 | vsDrake | L57-75 | 1-6 | .143 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 10 | Sun Dec 20 | vs TBD | W84-44 | 2-6 | .250 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Sat Jan 2 | vs Denver | W93-54 | 3-6 | .333 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 12 | Sun Jan 3 | vsDenver | W79-57 | 4-6 | .400 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Fri Jan 8 | at Kansas City | W66-64 | 5-6 | .455 | - | | Swinney Recreation Center · Kansas City, MO |
| 14 | Sat Jan 9 | atKansas City | W68-62 | 6-6 | .500 | - | | Swinney Recreation Center · Kansas City, MO |
| 15 | Fri Jan 22 | at W Illinois | W65-60 | 7-6 | .538 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 16 | Sat Jan 23 | atW Illinois | W84-74 | 8-6 | .571 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 17 | Fri Jan 29 | vs Omaha | W91-59 | 9-6 | .600 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 18 | Sat Jan 30 | vsOmaha | W97-93 | 10-6 | .625 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 19 | Fri Feb 5 | atS Dakota St | W64-56 | 11-6 | .647 | - | | Frost Arena · Brookings, SD |
| 20 | Sat Feb 6 | atS Dakota St | L78-89 | 11-7 | .611 | - | | Frost Arena · Brookings, SD |
| 21 | Sat Feb 13 | atNorth Dakota | L76-85 | 11-8 | .579 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 22 | Sun Feb 14 | atNorth Dakota | L81-85 | 11-9 | .550 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 23 | Sat Feb 20 | vs Oral Roberts | W86-84 | 12-9 | .571 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 25 | Sat Feb 27 | vsN Dakota St | W80-71 | 13-9 | .591 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 26 | Sun Feb 28 | vsN Dakota St | L77-89 | 13-10 | .565 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 27 | Sat Mar 6 | vsW Illinois | W86-69 | 14-10 | .583 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 28 | Mon Mar 8 | vsN Dakota St | L75-79 | 14-11 | .560 | - | | Sanford Coyote Sports Center · Vermillion, SD |
