| 1 | Thu Nov 11 | vs Air Force | W59-53 | 1-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 2 | Sun Nov 14 | at Drake | L50-99 | 1-1 | .500 | - | | The Knapp Center · Des Moines, IA |
| 3 | Fri Nov 19 | vs Southern | W71-68 | 2-1 | .667 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 4 | Sun Nov 21 | vs Tennessee St | W83-66 | 3-1 | .750 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 5 | Tue Nov 23 | vs TBD | W99-58 | 4-1 | .800 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Sat Nov 27 | at Nebraska | L70-83 | 4-2 | .667 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 7 | Tue Nov 30 | at San Jose St | L52-61 | 4-3 | .571 | - | | Provident Credit Union Event Center · San Jose, CA |
| 8 | Fri Dec 3 | vsTBD | W93-37 | 5-3 | .625 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 9 | Tue Dec 7 | at N Colorado | L69-74 | 5-4 | .556 | - | | Bank of Colorado Arena · Greeley, CO |
| 10 | Sat Dec 11 | vs N Arizona | W76-71 (OT) | 6-4 | .600 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Wed Dec 15 | vs Bellarmine | W78-64 | 7-4 | .636 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 12 | Mon Dec 20 | vs Oral Roberts | L73-82 | 7-5 | .583 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Wed Dec 22 | vs Kansas City | L57-68 | 7-6 | .538 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 14 | Thu Dec 30 | at North Dakota | PPD | 19-12 | .613 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 15 | Sat Jan 1 | at N Dakota St | PPD | 19-12 | .613 | - | | Scheels Center · Fargo, ND |
| 16 | Sat Jan 8 | at S Dakota St | L65-84 | 7-7 | .500 | - | | Frost Arena · Brookings, SD |
| 17 | Mon Jan 10 | atNorth Dakota | W75-68 | 8-7 | .533 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 18 | Thu Jan 13 | vs Denver | W80-71 | 9-7 | .563 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 19 | Sat Jan 15 | vs Omaha | W105-70 | 10-7 | .588 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 20 | Thu Jan 20 | at W Illinois | PPD | 19-12 | .613 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 21 | Sat Jan 22 | at St Thomas (MN) | W90-79 | 11-7 | .611 | - | | Schoenecker Arena · Saint Paul, MN |
| 22 | Mon Jan 24 | atW Illinois | W75-72 | 12-7 | .632 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 23 | Thu Jan 27 | vsN Dakota St | L62-74 (OT) | 12-8 | .600 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 24 | Sat Jan 29 | vsNorth Dakota | W71-58 | 13-8 | .619 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 25 | Sat Feb 5 | vsS Dakota St | L79-89 | 13-9 | .591 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 26 | Mon Feb 7 | atN Dakota St | L74-76 | 13-10 | .565 | - | | Scheels Center · Fargo, ND |
| 27 | Thu Feb 10 | atOmaha | W91-69 | 14-10 | .583 | - | | Baxter Arena · Omaha, NE |
| 28 | Sat Feb 12 | atDenver | W84-76 | 15-10 | .600 | - | | Hamilton Gymnasium · Denver, CO |
| 29 | Thu Feb 17 | vsSt Thomas (MN) | W81-60 | 16-10 | .615 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 30 | Sat Feb 19 | vsW Illinois | W78-65 | 17-10 | .630 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 31 | Thu Feb 24 | atKansas City | L63-72 | 17-11 | .607 | - | | Swinney Recreation Center · Kansas City, MO |
| 32 | Sat Feb 26 | atOral Roberts | W92-87 | 18-11 | .621 | - | | Mabee Center · Tulsa, OK |
| 33 | Sun Mar 6 | atKansas City | W74-61 | 19-11 | .633 | - | | Swinney Recreation Center · Kansas City, MO |
| 34 | Mon Mar 7 | atS Dakota St | L60-83 | 19-12 | .613 | - | | Frost Arena · Brookings, SD |
