| 1 | Mon Nov 6 | vs TBD | W85-53 | 1-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 2 | Fri Nov 10 | vs UT Rio Grande | W100-79 | 2-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 3 | Tue Nov 14 | at DePaul | L60-72 | 2-1 | .667 | - | FS2 | Wintrust Arena · Chicago, IL |
| 4 | Fri Nov 17 | vs VMI | W85-81 | 3-1 | .750 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 5 | Sat Nov 18 | vs Purdue FW | L81-93 | 3-2 | .600 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Wed Nov 22 | vsTBD | W100-48 | 4-2 | .667 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 7 | Sun Nov 26 | vs Air Force | L57-58 | 4-3 | .571 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 8 | Tue Nov 28 | vsTBD | W93-71 | 5-3 | .625 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 9 | Sun Dec 3 | at W Illinois | W70-68 | 6-3 | .667 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 10 | Sat Dec 9 | vs Bakersfield | W78-73 | 7-3 | .700 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Sat Dec 16 | at UC Irvine | L78-121 | 7-4 | .636 | - | | Bren Events Center · Irvine, CA |
| 12 | Tue Dec 19 | atBakersfield | L76-96 | 7-5 | .583 | - | | Icardo Center · Bakersfield, CA |
| 13 | Thu Dec 21 | at San Diego | L66-69 | 7-6 | .538 | - | | Jenny Craig Pavilion · San Diego, CA |
| 14 | Fri Dec 29 | at N Dakota St | W75-66 | 8-6 | .571 | - | | Scheels Center · Fargo, ND |
| 15 | Sun Dec 31 | vs Omaha | L51-67 | 8-7 | .533 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 16 | Wed Jan 3 | vs E Washington | L79-93 | 8-8 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 17 | Sat Jan 6 | at Montana | L63-82 | 8-9 | .471 | - | | Dahlberg Arena · Missoula, MT |
| 18 | Thu Jan 11 | at Oral Roberts | L66-84 | 8-10 | .444 | - | | Mabee Center · Tulsa, OK |
| 19 | Thu Jan 18 | vs St Thomas (MN) | W74-73 (OT) | 9-10 | .474 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 20 | Sat Jan 20 | vs S Dakota St | L55-73 | 9-11 | .450 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 21 | Thu Jan 25 | at Denver | L110-111 (2OT) | 9-12 | .429 | - | | Hamilton Gymnasium · Denver, CO |
| 22 | Sat Jan 27 | at Kansas City | L57-81 | 9-13 | .409 | - | | Swinney Recreation Center · Kansas City, MO |
| 23 | Thu Feb 1 | vs North Dakota | L81-95 | 9-14 | .391 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 24 | Sun Feb 4 | atS Dakota St | L67-70 | 9-15 | .375 | - | CBS | Frost Arena · Brookings, SD |
| 25 | Thu Feb 8 | vsDenver | W92-86 (OT) | 10-15 | .400 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 26 | Thu Feb 15 | atOmaha | L84-91 | 10-16 | .385 | - | | Baxter Arena · Omaha, NE |
| 27 | Sat Feb 17 | atSt Thomas (MN) | L80-83 | 10-17 | .370 | - | | Schoenecker Arena · Saint Paul, MN |
| 28 | Thu Feb 22 | vsKansas City | L78-82 | 10-18 | .357 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 29 | Sat Feb 24 | vsOral Roberts | W77-76 | 11-18 | .379 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 30 | Thu Feb 29 | vsN Dakota St | W88-68 | 12-18 | .400 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 31 | Sat Mar 2 | atNorth Dakota | L66-95 | 12-19 | .387 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 32 | Fri Mar 8 | atOral Roberts | L62-77 | 12-20 | .375 | - | | Mabee Center · Tulsa, OK |
