| 1 | Fri Nov 8 | vs Pacific | W72-62 | 1-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 2 | Sun Nov 10 | at Hawai'i | W81-75 | 2-0 | 1.000 | - | | Stan Sheriff Center · Honolulu, HI |
| 3 | Mon Nov 11 | at FAMU | W85-82 | 3-0 | 1.000 | - | | Al Lawson Center · Tallahassee, FL |
| 4 | Fri Nov 15 | vs Texas So | W88-69 | 4-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 5 | Mon Nov 18 | vs SIUE | W71-56 | 5-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Fri Nov 22 | at Arkansas | L56-77 | 5-1 | .833 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 7 | Wed Nov 27 | at CA Baptist | W84-83 | 6-1 | .857 | - | | CBU Events Center · Riverside, CA |
| 8 | Sat Nov 30 | at N Arizona | L72-76 | 6-2 | .750 | - | | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 9 | Mon Dec 2 | at #22Washington | L55-75 | 6-3 | .667 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 10 | Fri Dec 6 | vs TBD | W94-79 | 7-3 | .700 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Mon Dec 9 | vs Alabama St | W73-59 | 8-3 | .727 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 12 | Sat Dec 14 | vsTBD | W96-60 | 9-3 | .750 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Fri Dec 20 | vs N Colorado | L68-87 | 9-4 | .692 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 14 | Sun Dec 22 | vs Kansas City | L75-78 | 9-5 | .643 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 15 | Sun Dec 29 | at W Illinois | L75-82 | 9-6 | .600 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 16 | Wed Jan 1 | at Purdue FW | L59-70 | 9-7 | .563 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 17 | Sun Jan 5 | vs Denver | W80-78 | 10-7 | .588 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 18 | Sat Jan 11 | vs Omaha | W91-81 | 11-7 | .611 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 19 | Wed Jan 15 | at N Dakota St | L70-72 | 11-8 | .579 | - | | Scheels Center · Fargo, ND |
| 20 | Sun Jan 19 | vs S Dakota St | W99-84 | 12-8 | .600 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 21 | Thu Jan 23 | vsPurdue FW | W83-60 | 13-8 | .619 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 22 | Sat Jan 25 | vs Oral Roberts | W91-80 | 14-8 | .636 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 23 | Thu Jan 30 | atDenver | W93-87 | 15-8 | .652 | - | | Hamilton Gymnasium · Denver, CO |
| 24 | Sun Feb 2 | atOmaha | W81-80 | 16-8 | .667 | - | | Baxter Arena · Omaha, NE |
| 25 | Tue Feb 4 | vsTBD | W106-45 | 17-8 | .680 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 26 | Sat Feb 8 | at North Dakota | W82-68 | 18-8 | .692 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 27 | Wed Feb 12 | vsW Illinois | W85-72 | 19-8 | .704 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 28 | Sat Feb 15 | atOral Roberts | L80-94 | 19-9 | .679 | - | | Mabee Center · Tulsa, OK |
| 29 | Wed Feb 19 | vsN Dakota St | L74-77 | 19-10 | .655 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 30 | Sun Feb 23 | atS Dakota St | L80-85 | 19-11 | .633 | - | | Frost Arena · Brookings, SD |
| 31 | Sat Feb 29 | vsNorth Dakota | W77-67 | 20-11 | .645 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 32 | Sun Mar 8 | vsNorth Dakota | L71-74 | 20-12 | .625 | - | | Sanford Coyote Sports Center · Vermillion, SD |
