| 1 | Mon Nov 7 | at Wisconsin | L59-85 | 0-1 | .000 | - | BTN | Kohl Center · Madison, WI |
| 2 | Wed Nov 9 | vs Lipscomb | W85-77 | 1-1 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 3 | Sat Nov 12 | vs TBD | W82-64 | 2-1 | .667 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 4 | Thu Nov 17 | at Mississippi St | L42-79 | 2-2 | .500 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 5 | Tue Nov 22 | at Long Island | W68-58 | 3-2 | .600 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 6 | Wed Nov 23 | at Sam Houston | L49-80 | 3-3 | .500 | - | | Bernard G. Johnson Coliseum · Huntsville, TX |
| 7 | Sat Nov 26 | at Coast Car | L59-66 | 3-4 | .429 | - | | The HTC Center · Conway, SC |
| 8 | Mon Nov 28 | vsTBD | W97-58 | 4-4 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 9 | Sat Dec 3 | at BYU | W69-68 | 5-4 | .556 | - | | Marriott Center · Provo, UT |
| 10 | Tue Dec 6 | at Air Force | L58-79 | 5-5 | .500 | - | | Clune Arena · Colorado Springs, CO |
| 11 | Sat Dec 10 | vs UC Irvine | L71-83 | 5-6 | .455 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 12 | Wed Dec 14 | vsCoast Car | L86-87 | 5-7 | .417 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Mon Dec 19 | at Kansas City | L45-62 | 5-8 | .385 | - | | Swinney Recreation Center · Kansas City, MO |
| 14 | Wed Dec 21 | at Oral Roberts | PPD | 12-19 | .387 | - | | Mabee Center · Tulsa, OK |
| 15 | Thu Dec 29 | vs St Thomas (MN) | W92-84 | 6-8 | .429 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 16 | Sat Dec 31 | vs W Illinois | W80-63 | 7-8 | .467 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 17 | Thu Jan 5 | at North Dakota | W62-60 | 8-8 | .500 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 18 | Sat Jan 7 | at N Dakota St | L61-73 | 8-9 | .471 | - | | Scheels Center · Fargo, ND |
| 19 | Sat Jan 14 | vs S Dakota St | L64-82 | 8-10 | .444 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 20 | Thu Jan 19 | vs Denver | L60-75 | 8-11 | .421 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 21 | Sat Jan 21 | vs Omaha | W84-68 | 9-11 | .450 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 22 | Thu Jan 26 | atW Illinois | L72-75 | 9-12 | .429 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 23 | Sat Jan 28 | atSt Thomas (MN) | W81-67 | 10-12 | .455 | - | | Schoenecker Arena · Saint Paul, MN |
| 24 | Mon Jan 30 | atOral Roberts | L53-103 | 10-13 | .435 | - | | Mabee Center · Tulsa, OK |
| 25 | Thu Feb 2 | vsN Dakota St | W71-62 | 11-13 | .458 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 26 | Sat Feb 4 | vsNorth Dakota | L72-86 | 11-14 | .440 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 27 | Sat Feb 11 | atS Dakota St | L67-72 | 11-15 | .423 | - | | Frost Arena · Brookings, SD |
| 28 | Thu Feb 16 | atOmaha | L72-80 | 11-16 | .407 | - | | Baxter Arena · Omaha, NE |
| 29 | Sat Feb 18 | atDenver | L68-86 | 11-17 | .393 | - | | Hamilton Gymnasium · Denver, CO |
| 30 | Thu Feb 23 | vsOral Roberts | L70-82 | 11-18 | .379 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 31 | Sat Feb 25 | vsKansas City | W82-48 | 12-18 | .400 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 32 | Sun Mar 5 | atN Dakota St | L68-70 | 12-19 | .387 | - | | Scheels Center · Fargo, ND |
