| 1 | Mon Nov 3 | vs Utah Tech | 8:30 PM | 7-26 | .212 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 2 | Wed Nov 5 | at#23Creighton | TBD | 25-11 | .694 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 3 | Sun Nov 9 | vsTBD | 2:00 PM | 0-0 | .000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 4 | Wed Nov 12 | vsSo Indiana | 8:00 PM | 10-20 | .333 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 5 | Sun Nov 16 | vsW Michigan | 2:00 PM | 12-20 | .375 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Thu Nov 20 | atMissouri | 8:00 PM | 22-12 | .647 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 7 | Sun Nov 23 | vsSC State | TBD | 20-13 | .606 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 8 | Sat Nov 29 | atAir Force | 3:00 PM | 4-28 | .125 | - | | Clune Arena · Colorado Springs, CO |
| 9 | Wed Dec 3 | vsPortland St | 8:00 PM | 19-13 | .594 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 10 | Sat Dec 6 | atN Colorado | 8:00 PM | 25-10 | .714 | - | | Bank of Colorado Arena · Greeley, CO |
| 11 | Tue Dec 9 | atWyoming | TBD | 12-20 | .375 | - | | Arena Auditorium · Laramie, WY |
| 12 | Sat Dec 13 | vsPrairie View | 2:00 PM | 5-27 | .156 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Wed Dec 17 | vsTBD | 8:00 PM | 0-0 | .000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 14 | Sat Dec 20 | atKansas St | 12:00 PM | 16-17 | .485 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 15 | Sun Dec 28 | vsTBD | 2:00 PM | 0-0 | .000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 16 | Wed Dec 31 | atN Dakota St | TBD | 21-11 | .656 | - | | Scheels Center · Fargo, ND |
| 17 | Wed Jan 7 | atSt Thomas (MN) | 9:00 PM | 24-10 | .706 | - | | Schoenecker Arena · Saint Paul, MN |
| 18 | Sat Jan 10 | vsDenver | 2:00 PM | 11-21 | .344 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 19 | Thu Jan 15 | vsKansas City | 8:00 PM | 13-20 | .394 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 20 | Sat Jan 17 | atNorth Dakota | 2:00 PM | 12-21 | .364 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 21 | Wed Jan 21 | atOmaha | TBD | 22-13 | .629 | - | | Baxter Arena · Omaha, NE |
| 22 | Sat Jan 24 | vsSt Thomas (MN) | 2:00 PM | 24-10 | .706 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 23 | Thu Jan 29 | vsOral Roberts | 8:00 PM | 7-23 | .233 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 24 | Sat Jan 31 | vsN Dakota St | 6:00 PM | 21-11 | .656 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 25 | Wed Feb 4 | atKansas City | TBD | 13-20 | .394 | - | | Swinney Recreation Center · Kansas City, MO |
| 26 | Sat Feb 7 | atS Dakota St | TBD | 20-12 | .625 | - | | Frost Arena · Brookings, SD |
| 27 | Wed Feb 11 | vsNorth Dakota | 8:00 PM | 12-21 | .364 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 28 | Thu Feb 19 | atDenver | 9:00 PM | 11-21 | .344 | - | | Hamilton Gymnasium · Denver, CO |
| 29 | Sat Feb 21 | atOral Roberts | TBD | 7-23 | .233 | - | | Mabee Center · Tulsa, OK |
| 30 | Thu Feb 26 | vsOmaha | 8:00 PM | 22-13 | .629 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 31 | Sat Feb 28 | vsS Dakota St | 2:00 PM | 20-12 | .625 | - | | Sanford Coyote Sports Center · Vermillion, SD |
