| 1 | Wed Nov 25 | at Kansas St | W80-70 | 1-0 | 1.000 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 2 | Fri Nov 27 | vs South Dakota | W69-53 | 2-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 3 | Thu Dec 3 | vs Omaha | W87-66 | 3-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 4 | Sun Dec 6 | vs TBD | W97-53 | 4-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 5 | Wed Dec 9 | vsTBD | W90-66 | 5-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 6 | Sun Dec 13 | vs Air Force | W81-53 | 6-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 7 | Wed Dec 16 | atSouth Dakota | PPD | 26-5 | .839 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 8 | Fri Dec 18 | atSouth Dakota | W75-57 | 7-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 9 | Sun Dec 20 | vs Chicago St | W111-67 | 8-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 10 | Tue Dec 22 | vs North Dakota | W88-55 | 9-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 11 | Sun Dec 27 | at Indiana St | W81-63 | 10-0 | 1.000 | - | | Hulman Center · Terre Haute, IN |
| 12 | Mon Dec 28 | atIndiana St | W73-66 | 11-0 | 1.000 | - | | Hulman Center · Terre Haute, IN |
| 13 | Sun Jan 3 | vs S Illinois | W73-55 | 12-0 | 1.000 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 14 | Mon Jan 4 | vsS Illinois | W86-55 | 13-0 | 1.000 | - | CBS | The Knapp Center · Des Moines, IA |
| 15 | Sun Jan 17 | at Missouri St | PPD | 26-5 | .839 | - | | Great Southern Bank Arena · Springfield, MO |
| 16 | Mon Jan 18 | atMissouri St | PPD | 26-5 | .839 | - | | Great Southern Bank Arena · Springfield, MO |
| 17 | Tue Jan 26 | atMissouri St | W68-61 | 14-0 | 1.000 | - | | Great Southern Bank Arena · Springfield, MO |
| 18 | Wed Jan 27 | atMissouri St | W78-73 | 15-0 | 1.000 | - | | Great Southern Bank Arena · Springfield, MO |
| 19 | Sun Jan 31 | vs Illinois St | W78-76 (OT) | 16-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 20 | Mon Feb 1 | vsIllinois St | W95-60 | 17-0 | 1.000 | #25 | | The Knapp Center · Des Moines, IA |
| 21 | Sat Feb 6 | at Valparaiso | W80-77 | 18-0 | 1.000 | #25 | | Athletics-Recreation Center · Valparaiso, IN |
| 22 | Sun Feb 7 | atValparaiso | L57-74 | 18-1 | .947 | #25 | | Athletics-Recreation Center · Valparaiso, IN |
| 23 | Wed Feb 10 | vs Northern Iowa | W80-59 | 19-1 | .950 | - | CBS | The Knapp Center · Des Moines, IA |
| 24 | Sat Feb 13 | vs #22Loyola Chicago | L54-81 | 19-2 | .905 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 25 | Sun Feb 14 | vs#22Loyola Chicago | W51-50 (OT) | 20-2 | .909 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 26 | Wed Feb 17 | atNorthern Iowa | W77-69 | 21-2 | .913 | - | | McLeod Center · Cedar Falls, IA |
| 27 | Sun Feb 21 | vs Evansville | W85-71 | 22-2 | .917 | - | | The Knapp Center · Des Moines, IA |
| 28 | Mon Feb 22 | vsEvansville | W74-63 | 23-2 | .920 | - | | The Knapp Center · Des Moines, IA |
| 29 | Fri Feb 26 | at Bradley | W80-71 | 24-2 | .923 | - | | Carver Arena · Peoria, IL |
| 30 | Sat Feb 27 | atBradley | L61-67 | 24-3 | .889 | - | | Carver Arena · Peoria, IL |
| 32 | Sat Mar 6 | vsMissouri St | W71-69 | 25-3 | .893 | - | CBS | The Knapp Center · Des Moines, IA |
| 33 | Sun Mar 7 | atLoyola Chicago | L65-75 | 25-4 | .862 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 34 | Thu Mar 18 | at #11Wichita St | W53-52 | 26-4 | .867 | #11 | TBS | Charles Koch Arena · Wichita, KS |
| 35 | Sat Mar 20 | at #6USC | L56-72 | 26-5 | .839 | #11 | TNT | Galen Center · Los Angeles, CA |
