| 1 | Wed Nov 8 | vs Lipscomb | W85-70 | 1-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 2 | Tue Nov 14 | vs TBD | W87-67 | 2-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 3 | Sun Nov 19 | vs Oakland | W85-77 | 3-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 4 | Mon Nov 20 | at SF Austin | L68-92 | 3-1 | .750 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 5 | Tue Nov 21 | at Akron | W79-59 | 4-1 | .800 | - | | James A. Rhodes Arena · Akron, OH |
| 6 | Sat Nov 25 | vs Texas So | W77-71 | 5-1 | .833 | - | | The Knapp Center · Des Moines, IA |
| 7 | Wed Nov 29 | at Valparaiso | W83-65 | 6-1 | .857 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 8 | Sat Dec 2 | vs Missouri St | W74-57 | 7-1 | .875 | - | | The Knapp Center · Des Moines, IA |
| 9 | Wed Dec 6 | vs Saint Louis | W75-69 | 8-1 | .889 | - | | The Knapp Center · Des Moines, IA |
| 10 | Sat Dec 9 | at Nevada | W72-53 | 9-1 | .900 | - | | Lawlor Events Center · Reno, NV |
| 11 | Thu Dec 14 | vs Grambling | W68-56 | 10-1 | .909 | - | | The Knapp Center · Des Moines, IA |
| 12 | Tue Dec 19 | vs Alcorn St | W92-55 | 11-1 | .917 | - | | The Knapp Center · Des Moines, IA |
| 13 | Fri Dec 22 | at UAB | L78-79 (OT) | 11-2 | .846 | - | | Bartow Arena · Birmingham, AL |
| 14 | Tue Jan 2 | vs Illinois St | W88-71 | 12-2 | .857 | - | CBS | The Knapp Center · Des Moines, IA |
| 15 | Sun Jan 7 | at Belmont | L65-87 | 12-3 | .800 | - | ESPN2 | Curb Event Center Arena · Nashville, TN |
| 16 | Wed Jan 10 | vs Indiana St | W89-78 | 13-3 | .813 | - | | The Knapp Center · Des Moines, IA |
| 17 | Sat Jan 13 | at S Illinois | W76-58 | 14-3 | .824 | - | ESPN2 | Banterra Center · Carbondale, IL |
| 18 | Wed Jan 17 | atIllinois St | W77-56 | 15-3 | .833 | - | | Redbird Arena · Normal, IL |
| 19 | Sat Jan 20 | vs Evansville | W97-48 | 16-3 | .842 | - | | The Knapp Center · Des Moines, IA |
| 20 | Wed Jan 24 | atMissouri St | L80-83 (2OT) | 16-4 | .800 | - | | Great Southern Bank Arena · Springfield, MO |
| 21 | Sat Jan 27 | vs Northern Iowa | W77-63 | 17-4 | .810 | - | | The Knapp Center · Des Moines, IA |
| 22 | Wed Jan 31 | vsValparaiso | W81-70 | 18-4 | .818 | - | | The Knapp Center · Des Moines, IA |
| 23 | Sat Feb 3 | atIndiana St | L67-75 | 18-5 | .783 | - | ESPN2 | Hulman Center · Terre Haute, IN |
| 24 | Wed Feb 7 | vsS Illinois | W92-88 (OT) | 19-5 | .792 | - | | The Knapp Center · Des Moines, IA |
| 25 | Sat Feb 10 | at Bradley | W74-67 | 20-5 | .800 | - | ESPNU | Carver Arena · Peoria, IL |
| 26 | Tue Feb 13 | atEvansville | W78-75 | 21-5 | .808 | - | | Ford Center · Evansville, IN |
| 27 | Sun Feb 18 | vs Murray St | W95-72 | 22-5 | .815 | - | | The Knapp Center · Des Moines, IA |
| 28 | Wed Feb 21 | vsBelmont | W84-69 | 23-5 | .821 | - | | The Knapp Center · Des Moines, IA |
| 29 | Sat Feb 24 | atNorthern Iowa | L77-91 | 23-6 | .793 | - | | McLeod Center · Cedar Falls, IA |
| 30 | Wed Feb 28 | at UIC | W107-105 (3OT) | 24-6 | .800 | - | | Credit Union 1 Arena · Chicago, IL |
| 31 | Sun Mar 3 | vsBradley | W74-66 | 25-6 | .806 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 32 | Fri Mar 8 | vsEvansville | W79-58 | 26-6 | .813 | - | | The Knapp Center · Des Moines, IA |
| 33 | Sat Mar 9 | vsBradley | W72-67 | 27-6 | .818 | - | CBS | The Knapp Center · Des Moines, IA |
| 34 | Sun Mar 10 | atIndiana St | W84-80 | 28-6 | .824 | - | CBS | Hulman Center · Terre Haute, IN |
| 35 | Thu Mar 21 | at #7Washington St | L61-66 | 28-7 | .800 | #10 | truTV | Friel Court at Beasley Coliseum · Pullman, WA |
