| 1 | Wed Nov 9 | vs IU Indy | W80-48 | 1-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 2 | Mon Nov 14 | vsWofford | W80-72 | 2-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 3 | Fri Nov 18 | vsBuffalo | W80-72 | 3-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 4 | Sun Nov 20 | atWyoming | W61-56 | 4-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 5 | Mon Nov 21 | atTarleton | W71-64 | 5-0 | 1.000 | - | | placeholder · sf, ca |
| 6 | Sat Nov 26 | vsLouisiana | W76-64 | 6-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 7 | Wed Nov 30 | atIndiana St | L73-75 | 6-1 | .857 | - | | Hulman Center · Terre Haute, IN |
| 8 | Sat Dec 3 | vsUIC | W77-64 | 7-1 | .875 | - | | The Knapp Center · Des Moines, IA |
| 9 | Wed Dec 7 | vsOmaha | W78-65 | 8-1 | .889 | - | | The Knapp Center · Des Moines, IA |
| 10 | Sat Dec 10 | atRichmond | L52-82 | 8-2 | .800 | - | | Robins Center · Richmond, VA |
| 11 | Sat Dec 17 | atSaint Louis | L75-83 | 8-3 | .727 | - | | Chaifetz Arena · St. Louis, MO |
| 12 | Tue Dec 20 | vsMississippi St | W58-52 | 9-3 | .750 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 13 | Wed Dec 21 | vsTBD | W124-48 | 10-3 | .769 | - | | The Knapp Center · Des Moines, IA |
| 14 | Thu Dec 29 | vsValparaiso | W68-63 | 11-3 | .786 | - | CBS | The Knapp Center · Des Moines, IA |
| 15 | Sun Jan 1 | atMissouri St | L49-52 | 11-4 | .733 | - | | Great Southern Bank Arena · Springfield, MO |
| 16 | Wed Jan 4 | atS Illinois | L49-53 | 11-5 | .688 | - | | Banterra Center · Carbondale, IL |
| 17 | Sat Jan 7 | vsMurray St | W82-64 | 12-5 | .706 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 18 | Tue Jan 10 | atUIC | W76-71 (OT) | 13-5 | .722 | - | | Credit Union 1 Arena · Chicago, IL |
| 19 | Sat Jan 14 | vsBradley | W86-61 | 14-5 | .737 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 20 | Wed Jan 18 | vsMissouri St | L62-65 (OT) | 14-6 | .700 | - | | The Knapp Center · Des Moines, IA |
| 21 | Sat Jan 21 | atEvansville | W97-61 | 15-6 | .714 | - | | Ford Center · Evansville, IN |
| 22 | Tue Jan 24 | vsIndiana St | W70-68 | 16-6 | .727 | - | CBS | The Knapp Center · Des Moines, IA |
| 23 | Sun Jan 29 | atBelmont | W79-61 | 17-6 | .739 | - | ESPN2 | Curb Event Center Arena · Nashville, TN |
| 24 | Wed Feb 1 | vsNorthern Iowa | W88-81 (2OT) | 18-6 | .750 | - | | The Knapp Center · Des Moines, IA |
| 25 | Sat Feb 4 | atValparaiso | W85-82 (2OT) | 19-6 | .760 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 26 | Tue Feb 7 | atMurray St | W92-68 | 20-6 | .769 | - | | CFSB Center · Murray, KY |
| 27 | Sat Feb 11 | vsS Illinois | W82-59 | 21-6 | .778 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 28 | Wed Feb 15 | atNorthern Iowa | W82-74 | 22-6 | .786 | - | | McLeod Center · Cedar Falls, IA |
| 29 | Sun Feb 19 | vsBelmont | W70-56 | 23-6 | .793 | - | CBS | The Knapp Center · Des Moines, IA |
| 30 | Wed Feb 22 | vsIllinois St | W82-51 | 24-6 | .800 | - | | The Knapp Center · Des Moines, IA |
| 31 | Sun Feb 26 | atBradley | L61-73 | 24-7 | .774 | - | ESPN2 | Carver Arena · Peoria, IL |
| 32 | Fri Mar 3 | vsMurray St | W74-62 | 25-7 | .781 | - | | The Knapp Center · Des Moines, IA |
| 33 | Sat Mar 4 | vsS Illinois | W65-52 | 26-7 | .788 | - | CBS | The Knapp Center · Des Moines, IA |
| 34 | Sun Mar 5 | atBradley | W77-51 | 27-7 | .794 | - | CBS | Carver Arena · Peoria, IL |
| 35 | Fri Mar 17 | at#5Miami | L56-63 | 27-8 | .771 | #12 | TBS | MVP Arena · Albany, NY |
